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How gut bacteria regulate stress and sleep cycles

This study reveals that gut microbiota, particularly Lactobacillus species, regulate the daily rhythm of stress hormones like corticosterone, influencing stress responses and brain function at different times of the day. Disruptions in gut bacteria lead to altered stress responses and increased susceptibility to disorders like depression.

10 Nov 2024

Exploring the protective effects of HSD17B13 in hepatic steatosis

Chronic liver disease (CLD) is a growing global health challenge, accounting for millions of deaths each year. Its major contributors include metabolic dysfunction-associated steatohepatitis (MASH), alcoholic liver disease (ALD), and hepatitis C virus infection.

8 Nov 2024

Mediterranean diet may reduce type-2 diabetes risk in fatty liver patients

Researchers investigate how Mediterranean diet adherence reduces risk of type-2 diabetes in adults with metabolic dysfunction-associated fatty liver disease.

8 Nov 2024

Targeting ferroptosis for overcoming chemoresistance in digestive tract tumors

The global burden of digestive tract tumors is profound, with these cancers accounting for nearly half of all malignant tumors worldwide.

8 Nov 2024

Traditional Chinese herb shows promise against Alzheimer’s and Parkinson’s

Zizyphi spinosi semen demonstrates neuroprotective effects, improving cognitive function and reducing amyloid and tau pathology in models of aging and dementia.

8 Nov 2024

Copper accumulation linked to aggressive growth of kidney cancer

A new study led by University of Cincinnati Cancer Center researchers details how the accumulation of copper helps clear cell renal cell carcinoma (ccRCC) - the most common kidney cancer - grow and advance in stage.

7 Nov 2024

Preeclampsia and COVID-19 share pathophysiological similarities in pregnant women

During the COVID-19 pandemic, above all before vaccines were available, an alarm was sounded regarding a possible correlation between severe cases of COVID-19 in pregnant women and preeclampsia, a condition characterized by high blood pressure (hypertension) in the expectant mother and high levels of protein in her urine (proteinuria). It can entail dangerous complications for mother and baby.

7 Nov 2024

CRISPR technology reveals essential noncoding RNAs in the human genome

Genes contain instructions for making proteins, and a central dogma of biology is that this information flows from DNA to RNA to proteins.

7 Nov 2024

Study links high blood sugar to thrombosis risk in diabetes

A study conducted at the Center for Research on Redox Processes in Biomedicine (Redoxoma) helps understand how high blood sugar (hyperglycemia), one of the manifestations of diabetes, can cause thrombosis.

6 Nov 2024

Saturated fats accelerate neurodegeneration in multiple sclerosis

Targeting ceramide synthase enzymes may reduce multiple sclerosis severity by limiting ceramide C16 synthesis, offering potential neuroprotective strategies.

6 Nov 2024

Solascure and U.S. Army Institute of Surgical Research collaborate for combat wound care

SOLASCURE Ltd ("SolasCure"), a biotechnology company developing a novel treatment to transform chronic wound care and the U.S. Army Institute of Surgical Research ("USAISR"), today announced a research collaboration to evaluate SolasCure's investigational product, Aurase Wound Gel, as a means for managing combat wounds.

From SolasCure 6 Nov 2024

Gene editing with CRISPR may introduce new defects

The CRISPR tool is capable of repairing the genetic defect responsible for the immune disease chronic granulomatous disease.

6 Nov 2024

CHiTA assay identifies functional twister ribozymes

The "RNA world" hypothesis proposes that the earliest life on Earth may have been based on RNA - a single-stranded molecule similar in many ways to DNA - like some modern viruses. This is because, like DNA, RNA can carry genetic information, but, like a protein, it can also act as an enzyme, initiating or accelerating reactions.

5 Nov 2024

New insights into early Huntington's disease mechanisms

Researchers uncover a link between impaired glutathione–ascorbate metabolism and early dopamine increases in Huntington's disease, suggesting GSTO2 as a potential therapeutic target to manage motor dysfunction.

4 Nov 2024

Researchers develop the first polymer-based therapeutic for Huntington’s disease

Breakthrough polymer-based therapy shows promise in reversing Huntington's disease symptoms by preventing toxic protein clumps and enhancing neuronal survival.

4 Nov 2024

New study identifies potential treatment for tauopathies using carbonic anhydrase inhibitors

Carbonic anhydrase inhibitors show potential in reducing tau protein buildup, offering new therapeutic avenues for neurodegenerative diseases like tauopathies.

4 Nov 2024

Carbonic anhydrase inhibitors clear tau build-up in zebrafish models of tauopathies

A drug commonly used to treat glaucoma has been shown in zebrafish and mice to protect against the build-up in the brain of the protein tau, which causes various forms of dementia and is implicated in Alzheimer’s disease.

4 Nov 2024

Researchers achieve accurate EV analysis to detect brain disease

Brain disorders like Parkinson's (PD) or Alzheimer's Disease (AD) start to develop in patients much earlier than when their first clinical symptoms appear. Treating patients at these early stages could slow or even stop their disease, but there is currently no way to diagnose brain disorders at those pre-symptomatic stages.

3 Nov 2024

Glaucoma medication may help prevent Alzheimer's-related tau build-up

1 Nov 2024

Scientists uncover new MRSA resistance mechanism

Scientists have discovered the mechanism which allows the superbug Methicillin Resistant Staphylococcus aureus (MRSA) to become highly resistant to antibiotics, paving the way for new approaches to control infectious disease.

1 Nov 2024