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New insights into serine hydroxymethyltransferase aid cancer drug design

In just two neutron experiments, scientists discovered remarkable details about the function of an enzyme that can aid drug design for aggressive cancers.

26 Sep 2024

Novel mechanism enhances bacteria's defense against environmental threats

Researchers from Umeå University, Sweden, and Cornell University, USA, have discovered a widespread mechanism in bacteria that enhances the bacteria's defense against environmental threats.

26 Sep 2024

Researchers explore new metabolic pathway to fight cancer

When an aggressive cancer launches an invasion on the human body, anything that can be done to slow down or better understand that fast-paced assault is going to be a bonus.

26 Sep 2024

Breakthrough research offers hope for improved treatment of chronic wounds

Novel research, presented today at the European Academy of Dermatology and Venereology (EADV) Congress 2024, has identified key molecular targets that could significantly enhance the healing of both acute and chronic wounds.

25 Sep 2024

Study sheds light on mechanisms behind liver fibrosis and potential therapies

New research from the University of Pittsburgh School of Pharmacy sheds light on the processes that lead to liver fibrosis and suggests a novel treatment approach for this common and serious condition.

25 Sep 2024

Study: Obstructive sleep apnea may be a risk factor for abdominal aortic aneurysms

Obstructive sleep apnea may be a risk factor for developing abdominal aortic aneurysms, according to researchers from the University of Missouri School of Medicine and NextGen Precision Health.

25 Sep 2024

CRISPR-Cas13 emerges as a game changer in RNA-targeted therapies

In recent years, the scientific community has made significant strides in the field of gene editing, particularly through the development of the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) systems.

25 Sep 2024

Chemical genetics uncovers promising anti-COVID compounds

This new article publication from Acta Pharmaceutica Sinica B, discusses the identification of novel small-molecule inhibitors of SARS-CoV-2 by chemical genetics.

25 Sep 2024

Researchers gain new understanding of how immune cells respond to heat during fever

The study reveals that moderate fever enhances CD4 T cell activity while reducing regulatory T cell suppression, highlighting temperature's immune effects.

25 Sep 2024

Research reveals key role of mucin modification in muco-obstructive diseases

With each breath, a human may inhale thousands of harmful microbes into the lungs. Mucus, the gel-like moist substance coating the airways, is one of the first lines of defense and aids in removal these microbes.

24 Sep 2024

New insights into the mechanism of autophagy activation

24 Sep 2024

Scientists identify new trigger for autophagy

An international research team led by Osaka University has identified a new mechanism crucial for the initiation of autophagy, a self-degradation process cells use to eliminate unneeded or damaged components. In recent years, autophagy has also been recognized for its roles in aging and lifespan regulation.

24 Sep 2024

Calcium channel blockers show potential to restore cerebral blood flow in Alzheimer's disease

Targeting calcium channels in pericytes may improve blood flow in Alzheimer's disease, addressing early vascular dysfunction linked to cognitive deficits.

23 Sep 2024

New insights into lasso peptides offer promise for drug development

Lasso peptides are natural products made by bacteria. Their unusual lasso shape endows them with remarkable stability, protecting them from extreme conditions

20 Sep 2024

How plant-based, Mediterranean, and Western diets affect gut microbiota and disease

Researchers examine how different dietary components affect the gut microbiome and development of non-communicable diseases.

20 Sep 2024

Plasma pTau181 predicts Alzheimer’s progression in real-world memory clinic patients

Researchers confirm plasma pTau181 is a strong predictor for Alzheimer's in patients with mild cognitive impairment, offering a less invasive diagnostic tool for early intervention.

20 Sep 2024

Janus particles enable highly precise measurements in microfluidic devices

The importance of testing for diseases was thrust into the limelight during the COVID-19 pandemic. Many of us have undergone a PCR (Polymerase Chain Reaction) or ELISA (Enzyme-Linked Immunosorbent Assay) test within the past four years.

20 Sep 2024

Cellular sludge around hunger neurons linked to worsening diabetes and obesity

Investigating ECM changes in the hypothalamus reveals mechanisms behind insulin resistance, offering insights into obesity and metabolic disease treatment.

19 Sep 2024

Cardiovascular disease pathways associated with psoriasis, but not other immune-mediated diseases

A genetic connection between cardiovascular disease and psoriasis highlights shared inflammatory pathways, emphasizing the need for cardiovascular monitoring.

19 Sep 2024

Leptin variations may influence brain health and dementia development

New research is more closely linking obesity to dementia. Higher levels of leptin, a hormone that helps maintain normal body weight, is associated with better signal-transmitting brain white matter in middle-aged adults, according to a study by The University of Texas Health Science Center at San Antonio (UT Health San Antonio).

18 Sep 2024