Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

New insights into macrophage function in acute kidney injury

Acute kidney injury (AKI) is associated with a poor prognosis, and no effective treatment has been established to date. Understanding the mechanisms that prevent the progression of AKI is crucial.

27 Sep 2024

Why hypoglycemia-induced glucagon secretion becomes impaired in diabetes

Findings indicate that excessive somatostatin inhibits glucagon secretion in type 1 diabetes, offering a novel target for hypoglycemia management strategies.

27 Sep 2024

Patient-derived gut organoids reveal new insights into Crohn's disease subtypes

Crohn's disease - an autoimmune disorder - is characterized by chronic inflammation of the digestive tract, resulting in a slew of debilitating gastrointestinal symptoms that vary from patient to patient.

26 Sep 2024

Study reveals positive correlation between type 2 immunity and long-term cancer remission

Results from a preclinical study in mice, led by EPFL, and a collaborative clinical study in patients show that the type 2 immune response – associated with parasitic infection and thought to play a negative role in cancer immunity – is positively correlated with long-term cancer remission.

26 Sep 2024

Why children with Down’s syndrome are predisposed to developing leukaemia

The study uncovers mechanisms linking Down syndrome to leukemia, emphasizing the role of oxidative stress and genetic alterations in fetal blood development.

26 Sep 2024

Centenarians' stem cells unlock secrets to healthy aging

Individuals who display exceptional longevity provide evidence that humans can live longer, healthier lives.

25 Sep 2024

Breakthrough research offers hope for improved treatment of chronic wounds

Novel research, presented today at the European Academy of Dermatology and Venereology (EADV) Congress 2024, has identified key molecular targets that could significantly enhance the healing of both acute and chronic wounds.

25 Sep 2024

CRISPR-Cas13 emerges as a game changer in RNA-targeted therapies

In recent years, the scientific community has made significant strides in the field of gene editing, particularly through the development of the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) systems.

25 Sep 2024

Researchers gain new understanding of how immune cells respond to heat during fever

The study reveals that moderate fever enhances CD4 T cell activity while reducing regulatory T cell suppression, highlighting temperature's immune effects.

25 Sep 2024

Groundbreaking project seeks to illuminate the complexities of Parkinson's

Launching today, Landmark is a groundbreaking three-year research programme that aims to understand Parkinson’s in unprecedented detail. The project brings together Parkinson’s UK, Imperial College London, GSK, Novartis, Roche and UCB for the first time, and has been made possible by a founding gift of £4 million from the Gatsby charitable foundation.

24 Sep 2024

Mediterranean diet during pregnancy reduces childhood obesity risk

Following a Mediterranean diet during pregnancy reduced the likelihood of children being overweight or obese by age two, with no cases of obesity in the diet group. The diet’s influence on the leptin gene may explain these effects.

22 Sep 2024

Hypothalamic ECM remodeling drives insulin resistance, contributing to obesity and diabetes

Researchers have discovered that remodeling of extracellular matrix (ECM) in the hypothalamus, specifically around AgRP neurons, drives insulin resistance and metabolic disease. Disrupting this ECM buildup improves insulin sensitivity and may be a promising treatment for obesity and diabetes.

19 Sep 2024

Do long genes hold the key to understanding the genetic underpinnings of aging?

Review highlights the growing evidence that aging is linked to reduced expression of long genes, offering insights into potential anti-aging therapies based on gene length.

19 Sep 2024

FORT-2 trial shows promising results for bladder cancer immunotherapy combination

Findings from the international FORT-2 clinical trial showed that a combination treatment including immunotherapy is safe and tolerable in patients with locally advanced or metastatic bladder cancer.

19 Sep 2024

MicroRNA profiles help assess cancer risk in Lynch syndrome carriers

In his doctoral dissertation completed at the University of Jyväskylä, Finland, Tero Sievänen demonstrates that the cancer risk of Lynch syndrome carriers can be assessed based on circulating microRNA profiles.

18 Sep 2024

Discovery of 5-formylcytosine as an activating epigenetic switch

The team of Professor Christof Niehrs at the Institute of Molecular Biology (IMB) in Mainz, Germany, has discovered that a DNA modification called 5-formylcytosine (5fC) functions as an activating epigenetic switch that kick-starts genes in early embryonic development.

18 Sep 2024

Impact of oxidative stress, gut, and diet on attention deficit hyperactivity disorder pathophysiology

Oxidative stress and gut microbiome interactions are key in ADHD pathogenesis, with diet playing a crucial role in managing symptoms and improving outcomes.

18 Sep 2024

INTEGRA Biosciences’ pipettes pave the way for epigenetics testing

Genknowme, a start-up specializing in epigenetics research, has integrated multichannel pipettes from INTEGRA Biosciences into its liquid handling workflows. These liquid handling solutions will enable the lab to provide fast epigenetic assessments that will support healthcare professionals in suggesting lifestyle changes to improve their patients’ quality of life.

From INTEGRA Biosciences 17 Sep 2024

How stress reduces sperm motility by altering mitochondria

Researchers investigate the effects of perceived stress on sperm motility and maturation.

16 Sep 2024

Mount Sinai researchers uncover genetic basis of fibromuscular dysplasia

Mount Sinai researchers have identified a key driver of a blood vessel disorder known as fibromuscular dysplasia (FMD) which affects up to five percent of the adult population and can lead to high blood pressure, heart attack, or stroke.

14 Sep 2024