Prophylaxis News and Research

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AHA/ASA honors UCLA Medical Center with Get With The Guidelines-Stroke award

Ronald Reagan UCLA Medical Center has received the American Heart Association/American Stroke Association's Get With The Guidelines-Stroke Gold Plus Quality Achievement Award.

25 Oct 2012

EMA CHMP issues positive opinion to Savient's KRYSTEXXA for treatment of chronic gout

Savient Pharmaceuticals, Inc. and its wholly owned subsidiary, Savient Pharma Ireland Limited, announced that the European Medicines Agency's Committee for Medicinal Products for Human Use has completed its scientific assessment and has issued a positive opinion recommending approval of a marketing authorization in the European Union for KRYSTEXXA for the treatment of severe debilitating chronic tophaceous gout in adult patients who may also have erosive joint involvement and who have failed to normalize serum uric acid with xanthine oxidase inhibitors at the maximum medically appropriate dose or for whom these medicines are contraindicated.

19 Oct 2012

Computerized checklist helps physicians to prevent dangerous venous thromboembolisms or PE

A computerized checklist system designed to help physicians identify and use the best methods of preventing potentially deadly blood clots in hospitalized trauma patients dramatically reduced the number of these dangerous venous thromboembolisms (VTEs), new Johns Hopkins research suggests.

16 Oct 2012

Obesity does not affect VTE risk after knee surgery

Being morbidly obese does not increase the risk for developing venous thromboembolism after total knee arthroplasty surgery, report US researchers.

15 Oct 2012

Merck, AiCuris enter licensing agreement for novel HCMV candidates

Merck, known as MSD outside the United States and Canada, and AiCuris today announced that they have entered into an exclusive worldwide licensing agreement for AiCuris' novel portfolio of investigational medicines targeting Human Cytomegalovirus (HCMV), including letermovir (AIC246), an oral, late-stage antiviral candidate being investigated for the treatment and prevention of HCMV infection in transplant recipients.

15 Oct 2012

Curcumin can inhibit formation of prostate cancer metastases

Powdered turmeric has been used for centuries to treat osteoarthritis and other illnesses. Its active ingredient, curcumin, inhibits inflammatory reactions. A new study led by a research team at Ludwig-Maximilians-Universit-t (LMU) in Munich now shows that it can also inhibit formation of metastases.

13 Oct 2012

Hemophilia bleeding risk ‘low’ for childhood sports

Vigorous physical activity is associated with a moderate but transient bleeding risk for hemophilia, resulting in an overall low risk for bleeds, suggests a study of Australian children.

10 Oct 2012

Genocea raises $30M in Series C financing round

Genocea Biosciences, Inc., a clinical-stage company advancing innovative T cell vaccines for infectious diseases, has raised $30 million in a Series C financing round.

10 Oct 2012

Physical activity associated with increased risk of bleeding in children with hemophilia

Hemophilia is a bleeding disorder that, if untreated, causes recurrent bleeding into joints. "Vigorous physical activity is thought to increase risk of bleeds in children with hemophilia, but the magnitude of the risk is unknown," according to background information in the article. Information about risks associated with physical activity is needed to help inform decisions regarding participation in physical activity, the authors write.

10 Oct 2012

Best-practices protocol significantly reduces ventilator-associated pneumonia

An intensive care unit-initiated protocol implementing “best practices” significantly reduces ventilator-associated pneumonia, research shows.

8 Oct 2012

I COUGH program reduces likelihood of respiratory complications in surgical patients

Respiratory complications—including pneumonia and ventilator dependency—are among the most common complications that occur after operations. But a simple and inexpensive postoperative pulmonary care program known as "I COUGH" reduces the likelihood of those life-threatening and costly complications, researchers from Boston University Medical Center reported today at the 2012 American College of Surgeons (ACS) Annual Clinical Congress.

5 Oct 2012

Multicomponent strategies needed to prevent in-hospital delirium

Delirium in hospitalized adult patients indicates poor long-term outcomes and should be identified promptly and dealt with using evidence-based multicomponent strategies, suggest the authors of a systematic review.

1 Oct 2012

New malaria-transmitting mosquitoes: an interview with Jennifer Stevenson, Research Fellow at the London School of Hygiene & Tropical Medicine

In the area in which we carried out the study, which was in the western Kenyan highlands, the main mosquitoes that have been confirmed to transmit malaria are the females of Anopheles gambiae sensu stricto, Anopheles arabiensis and Anopheles funestus.

28 Sep 2012

Positive results from Sobi, Biogen Idec's rFIXFc Phase 3 trial on hemophilia B

Biogen Idec and Swedish Orphan Biovitrum (Sobi) today announced positive results from B-LONG, a clinical study that evaluated a new long-lasting clotting factor candidate in people with hemophilia B. Hemophilia B is a rare inherited disorder that impairs blood coagulation.

27 Sep 2012

Astellas seeks FDA approval for tacrolimus NDA for prophylaxis of organ rejection

Astellas Pharma US, Inc., a U.S. subsidiary of Tokyo-based Astellas Pharma Inc., today announced it has submitted a New Drug Application (NDA) to the U.S. Food and Drug Administration seeking approval for tacrolimus extended release capsules for the prophylaxis of organ rejection in adult kidney transplant recipients and adult male liver transplant recipients.

24 Sep 2012

Study estimates drug concentrations of Truvada and tenofovir to reduce risk of HIV among MSM

Several large clinical trials have demonstrated that a daily oral dose of one or two antiretroviral drugs used to treat HIV infection can prevent infection in an approach known as pre-exposure prophylaxis, or PrEP.

15 Sep 2012

Protocol adherence enhances outcomes in fast-track colorectal surgery

Outcomes following fast-track colorectal surgery are directly related to adherence to enhanced recovery after surgery protocols, shows an Italian study.

13 Sep 2012

Case Western Reserve researcher discovers new antivirulence drugs against MRSA and strep

Menachem Shoham, PhD, associate professor of biochemistry at Case Western Reserve University School of Medicine, has discovered novel antivirulence drugs that, without killing the bacteria, render Methicillin Resistant Staphylococcus Aureus (MRSA) and Streptococcus pyogenes, commonly referred to as strep, harmless by preventing the production of toxins that cause disease.

13 Sep 2012

Early CATCH improves thrombocytopenia outcomes

One in five patients using heparin to protect against venous thromboembolism develops thrombocytopenia, reveal results from the CATCH Registry.

12 Sep 2012

Researchers, policymakers to gather at AIDS Vaccine 2012 conference in Boston

"With a completed trial in Thailand that offered evidence a vaccine could be developed to protect people from HIV, emerging science identifying antibodies against HIV, and a current trial testing a novel vaccine combination against the virus potentially producing more information in the next year, this is an exciting time to hold a conference, organizers of AIDS Vaccine 2012 say," the Center for Global Health Policy's "Science Speaks" blog reports.

7 Sep 2012

Prophylaxis News and Research

AHA/ASA honors UCLA Medical Center with Get With The Guidelines-Stroke award

EMA CHMP issues positive opinion to Savient's KRYSTEXXA for treatment of chronic gout

Computerized checklist helps physicians to prevent dangerous venous thromboembolisms or PE

Obesity does not affect VTE risk after knee surgery

Merck, AiCuris enter licensing agreement for novel HCMV candidates

Curcumin can inhibit formation of prostate cancer metastases

Hemophilia bleeding risk ‘low’ for childhood sports

Genocea raises $30M in Series C financing round

Physical activity associated with increased risk of bleeding in children with hemophilia

Best-practices protocol significantly reduces ventilator-associated pneumonia

I COUGH program reduces likelihood of respiratory complications in surgical patients

Multicomponent strategies needed to prevent in-hospital delirium

New malaria-transmitting mosquitoes: an interview with Jennifer Stevenson, Research Fellow at the London School of Hygiene & Tropical Medicine

Positive results from Sobi, Biogen Idec's rFIXFc Phase 3 trial on hemophilia B

Astellas seeks FDA approval for tacrolimus NDA for prophylaxis of organ rejection

Study estimates drug concentrations of Truvada and tenofovir to reduce risk of HIV among MSM

Protocol adherence enhances outcomes in fast-track colorectal surgery

Case Western Reserve researcher discovers new antivirulence drugs against MRSA and strep

Early CATCH improves thrombocytopenia outcomes

Researchers, policymakers to gather at AIDS Vaccine 2012 conference in Boston

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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