Cell Death News and Research

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PLK1-mTOR axis may be a promising therapeutic target for sepsis, study suggests

Sepsis, one of the most acute and serious disease complications in the intensive care unit, is caused by various infections and results in life-threatening organ dysfunction.

26 Jan 2023

Special vascular cells sense when the brain region needs energy

When we smell hot dogs, it may trigger memories of backyard barbeques or attending baseball games during childhood.

26 Jan 2023

Altered gut microbiome plays a major role in the progression of endometriosis in animal model

About 196 million women worldwide suffer from endometriosis, a condition that typically causes pelvic pain and infertility.

25 Jan 2023

Researchers gain systematic insight into the organization of proteins in mitochondria

Mitochondria, the so-called powerhouse of the cells, are responsible for the energy supply of the organism and fulfill functions in metabolic and signaling processes.

25 Jan 2023

Targeting newly discovered signaling pathway could boost the potency of cancer therapeutics

Cells zealously protect the integrity of their genomes, because damage can lead to cancer or cell death. The genome - a cell's complete set of DNA - is most vulnerable while it is being duplicated before a cell divides. Cancer cells constantly are dividing, so their genomes are constantly in jeopardy.

24 Jan 2023

Researchers use multiplexed 3D imaging to perform molecular and morphological assessments of colorectal cancers

Researchers used multiplexed and three-dimensional imaging with machine-based learning and spatial statistics to perform molecular and morphological assessments of colorectal cancers (CRC).

24 Jan 2023

Study shows spatial organization in tumor cells

Researchers investigated whether the observed tumor cellular heterogeneity and architecture result from stochastic and chaotic events, or whether there is more coordination in the histopathological chaos of cancer.

24 Jan 2023

Researchers discover the gene responsible for radiation resistance in mutant IDH1 glioma

It's a good news, bad news story. Patients whose brain tumors have a mutated enzyme called IDH1 typically live longer than those without the mutation.

24 Jan 2023

Study uncovers protein that kick-starts milk production after breastfeeding is over

Scientists have discovered a protein that kick-starts milk production after breastfeeding is over - something which could provide effective new targets for cancer treatments.

19 Jan 2023

What are the major findings of long COVID research?

Researchers explored existing literature on long coronavirus disease (COVID). They highlighted key immunological findings, similarities with other diseases, symptoms, and associated pathophysiological mechanisms, and diagnostic and therapeutic options, including COVID-19 vaccinations.

17 Jan 2023

Study: Exposure to high doses of micro-sized polyethylene has adverse effects on cells

Exposure to high doses of micro-sized polyethylene has adverse effects on cells, a new study from the University of Eastern Finland finds.

17 Jan 2023

Protein heat shock transcription factor 1 may be a viable therapeutic target for hepatoblastoma

Although rare compared to adult liver cancers, hepatoblastoma is the most common pediatric liver malignancy, and its incidence is increasing.

16 Jan 2023

The trajectory of CD4+ T cell responses to mRNA vaccines in older individuals

Researchers investigated how age-related T-cell defects impacted the effectiveness of mRNA-based COVID-19 vaccines.

16 Jan 2023

CNB-CSIC vaccine fully protects against SARS-CoV-2 infection of the brain

In a recent study published in the journal Nature Neuroscience, researchers in Spain described the effectiveness of a modified vaccinia virus Ankara (MVA) vector severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine candidate in protecting against SARS-CoV-2 infection in the brain using a mouse model.

12 Jan 2023

RNAs may be a promising biomarker and therapeutic target for ischemic stroke

RUDN doctors analyzed the latest research on the use of RNA for the treatment and diagnosis of ischemic stroke.

10 Jan 2023

Researchers show how liver cancer cells hijack circadian clock machinery to divide and spread

The most common type of liver cancer, hepatocellular carcinoma (HCC), is already the third leading cause of cancer-related deaths globally - and cases are on the rise, both in the U.S. and worldwide.

6 Jan 2023

Research suggests potential therapeutic avenues to enhance PD-1 immune checkpoint sensitivity

A new research paper was published in Oncotarget's Volume 13 on December 20, 2022, entitled, "Resistance of MMTV-NeuT/ATTAC mice to anti-PD-1 immune checkpoint therapy is associated with macrophage infiltration and Wnt pathway expression."

6 Jan 2023

Researchers identify novel gene mechanism in most aggressive kidney cancers

In a new study from the Johns Hopkins Kimmel Cancer Center, researchers described a novel mechanism of tumor formation in kidney cancers driven by overexpression of the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway with loss of the tuberous sclerosis complex (TSC) tumor suppressor gene.

3 Jan 2023

Study investigates a new mechanism of pyrethroid derivatives-moderated programmed cell death

A new research paper was published in Oncotarget's Volume 13 on December 17, 2022, entitled, "The role of pyrethroid derivatives in autophagy and apoptosis crosstalk signaling and potential risk for malignancies."

29 Dec 2022

Checkerboard-like arrangement of inner ear cells vital for hearing, research reveals

A Japanese research group has become the first to reveal that the checkerboard-like arrangement of cells in the inner ear's organ of Corti is vital for hearing.

27 Dec 2022

Cell Death News and Research

PLK1-mTOR axis may be a promising therapeutic target for sepsis, study suggests

Special vascular cells sense when the brain region needs energy

Altered gut microbiome plays a major role in the progression of endometriosis in animal model

Researchers gain systematic insight into the organization of proteins in mitochondria

Targeting newly discovered signaling pathway could boost the potency of cancer therapeutics

Researchers use multiplexed 3D imaging to perform molecular and morphological assessments of colorectal cancers

Study shows spatial organization in tumor cells

Researchers discover the gene responsible for radiation resistance in mutant IDH1 glioma

Study uncovers protein that kick-starts milk production after breastfeeding is over

What are the major findings of long COVID research?

Study: Exposure to high doses of micro-sized polyethylene has adverse effects on cells

Protein heat shock transcription factor 1 may be a viable therapeutic target for hepatoblastoma

The trajectory of CD4+ T cell responses to mRNA vaccines in older individuals

CNB-CSIC vaccine fully protects against SARS-CoV-2 infection of the brain

RNAs may be a promising biomarker and therapeutic target for ischemic stroke

Researchers show how liver cancer cells hijack circadian clock machinery to divide and spread

Research suggests potential therapeutic avenues to enhance PD-1 immune checkpoint sensitivity

Researchers identify novel gene mechanism in most aggressive kidney cancers

Study investigates a new mechanism of pyrethroid derivatives-moderated programmed cell death

Checkerboard-like arrangement of inner ear cells vital for hearing, research reveals

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