Cell Proliferation News and Research

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Researchers report advances in efforts to improve treatment, prognosis of colorectal cancers

Georgios Margonis, M.D., Ph.D., a surgical oncology fellow at the Johns Hopkins University School of Medicine, and Matthew Weiss, M.D., surgical director of the Johns Hopkins Liver and Pancreas Cancer Multidisciplinary Clinics, report advances in efforts to improve the treatment and prognosis of colorectal cancers that have spread to the liver.

14 May 2018

Scientists discover potential therapeutic target for devastating premature aging disease

Scientists from the University of Cambridge have identified a potential therapeutic target in the devastating genetic disease Hutchinson-Gilford Progeria Syndrome (HGPS), which is characterized by premature aging.

27 Apr 2018

Specific type of RNA editing plays key role in protein variation in cancer cells, shows research

A multi-center study led by The University of Texas MD Anderson Cancer Center has shed light on why proteins, the seedlings that serve as the incubator for many cancers, can vary from cancer to cancer and even patient to patient, a discovery that adds to a growing base of knowledge important for developing more effective precision therapies.

27 Apr 2018

Researchers use 'top-down proteomics' strategy to get new insights into cancer

When a RAS gene operates normally, it acts as an on/off switch for cell signaling to control cell proliferation. But when the gene mutates, the switch jams into the "on" position, allowing cells to proliferate uncontrollably.

18 Apr 2018

New 'lymphoma micro-reactor' device targets chemo-resistant tumors

Non-Hodgkin lymphoma, a cancer that is diagnosed in the U.S. more than 70,000 times annually, arises from overly proliferating immune cells within the body's lymph nodes, which are connected to a network of lymph vessels through which lymphatic fluid flows.

12 Apr 2018

Finding new drug target for common form of lung cancer

Research by Rutgers Cancer Institute of New Jersey investigators has identified novel functions of the superoxide dismutase 1 (SOD1) enzyme providing support that it could serve as a therapeutic target in the most common type of lung cancer.

10 Apr 2018

Study uncovers mechanism causing chronic GVHD after bone marrow transplant

Allogeneic bone marrow transplant (BMT) is an essential treatment to cure patients with blood cancers such as leukemia. In patients who have undergone chemotherapy and radiation, a small number of cancer cells can remain in the bloodstream and allow the malignancy to recur.

3 Apr 2018

Molecular inhibitors found to arrest tumor cell proliferation in lung cancer and mesothelioma

Inhibition of the oncogenic kinase AKT, a key protein governing the cell cycle, was found to arrest cancer cell proliferation and triggered their programmed death by apoptosis.

2 Apr 2018

Viagra cuts colorectal cancer risk in animal model

A small, daily dose of Viagra significantly reduces colorectal cancer risk in an animal model that is genetically predetermined to have the third leading cause of cancer death, scientists report.

19 Mar 2018

Latest Atmospheric Control Unit now available for BMG LABTECH’s budget-friendly product line

Cell-based assays have become an important application in the life science sector, from basic to top-level research. They are widely used in biotech companies and academic research institutions to monitor cell health in real-time.

From BMG LABTECH GmbH 16 Mar 2018

Continuous tracking of melanoma cell invasion helps scientists explain key regulators of metastasis

A team of Italian scientists reported this week that blocking the interaction between urokinase receptor (uPAR) and formyl peptide receptor type 1 (FPR1) suppresses the ability of melanoma cells to migrate, invade through an extracellular matrix, and to burrow through a layer of endothelial cells.

13 Mar 2018

ACEA Biosciences develops novel assay for rapid identification of endocrine-disrupting chemicals

Endocrine-disrupting chemicals are substances that interfere with the ability of endogenous hormones to regulate homeostasis via their cognate nuclear receptors.

13 Mar 2018

New study finds that thirdhand smoke increases lung cancer risk in mice

Researchers at the Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) identified thirdhand smoke, the toxic residues that linger on indoor surfaces and in dust long after a cigarette has been extinguished, as a health hazard nearly 10 years ago.

9 Mar 2018

Carbon monoxide enhances efficacy of antibiotic against stomach infection

Carbon monoxide can improve the effectiveness of antibiotics, making bacteria more sensitive to antibiotic medication, according to a study led by Georgia State University.

22 Feb 2018

Researchers target abnormal epigenetic mechanisms involved in childhood cancers

Several childhood cancer cell types show features of immature neural cells, and there is evidence suggesting that these tumors may arise from neural crest stem cells that underwent abnormal changes during embryonic development.

20 Feb 2018

Researchers use molecular simulations to understand lung cancer drug resistance

Scientists from the Universities of Bristol and Parma, Italy, have used molecular simulations to understand resistance to osimertinib - an anticancer drug used to treat types of lung cancer.

12 Feb 2018

Cardiomyocytes fuse transiently during heart development and regeneration

Cardiomyocytes fuse during cardiac development and regeneration. A scientist of the German Centre for Cardiovascular Research (DZHK) discovered these previously unknown processes with the aid of genetically modified zebrafish in which fused cells fluoresce.

9 Feb 2018

Ribosomes found to be cause of somatic cell pluripotency

In 2012, a Japanese research group discovered that human skin cells acquire pluripotency when introduced to lactic acid bacteria. Now, the same group of researchers have found that the cause of somatic cell conversion into pluripotent stem cells is the ribosome, a protein synthesizing cellular organelle.

5 Feb 2018

Scientists discover role of two specific HOX genes in colon cancer development

In breakthrough colon cancer research, scientists at Christiana Care Health System's Center for Translational Cancer Research of the Helen F. Graham Cancer Center & Research Institute have discovered that over-expression of HOXA4 and HOXA9 genes in colon cancer stem cells promotes cell replication and contributes to the overpopulation of stem cells that drives colon cancer development.

31 Jan 2018

Implanted robotic system stimulates tissue growth in stunted organs

An implanted, programmable medical robot can gradually lengthen tubular organs by applying traction forces -- stimulating tissue growth in stunted organs without interfering with organ function or causing apparent discomfort, report researchers at Boston Children's Hospital.

11 Jan 2018