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Olaparib provides survival benefits for high-risk BRCA-positive breast cancer patients

Patients with high-risk, BRCA-positive breast cancer who received olaparib (Lynparza) after standard treatment continued to have better survival outcomes than those who received placebo after a median follow-up of 6.1 years, according to the latest results from the phase III OlympiA clinical trial presented at the San Antonio Breast Cancer Symposium (SABCS), held December 10-13, 2024.

11 Dec 2024

Herpes infections affect 846 million people worldwide

Around 846 million people aged between 15 and 49 are living with genital herpes infections – more than 1 in 5 of this age-group globally – according to new estimates released today.

11 Dec 2024

Intelligent toothbrush improves oral health and quality of life of older people

After seeing the oral health of many of his older patients deteriorate drastically, dentist Johan Flyborg started looking for a solution.

10 Dec 2024

Shivering for 1 hour a day may boost glucose tolerance and metabolic health

Daily cold exposure with shivering for 10 days improves glucose tolerance and metabolic health in individuals with obesity, highlighting shivering's role.

10 Dec 2024

New triplet therapies show promise for relapsed and newly diagnosed leukemias

Three clinical trials led by researchers from The University of Texas MD Anderson Cancer Center demonstrated significant positive results from novel triplet therapies in the treatment of relapsed or refractory and newly diagnosed leukemias.

9 Dec 2024

New advances offer hope for patients with systemic mastocytosis

Dana-Farber Cancer Institute researchers are breaking new ground in the fight against systemic mastocytosis, a rare and heterogeneous condition that is often challenging for clinicians to accurately diagnose and treat.

9 Dec 2024

Novel drug combination shows promise for CLL treatment

A novel, fixed-duration drug combination - consisting of a second-generation BTK inhibitor, called acalabrutinib, plus a BCL-2 inhibitor (venetoclax), with or without a third blood cancer drug - shows deep and durable responses in patients with chronic lymphocytic leukemia (CLL), Dana-Farber Cancer Institute investigator Jennifer Brown, MD, PhD, reports at the 66th American Society for Hematology (ASH) Annual Meeting and Exposition, on behalf of the trial investigators.

9 Dec 2024

Minoxidil found safe and effective for hair loss in breast cancer patients

Hair loss during chemotherapy can cause enough distress for some women to lose self-confidence, which experts say may discourage them from seeking chemotherapy in the first place.

9 Dec 2024

Mouse study links glyphosate to Alzheimer's-like brain changes and anxiety

Glyphosate exposure in mice exacerbates Alzheimer's-like neuropathologies, increases neuroinflammation, and leaves lasting effects, even after prolonged recovery.

9 Dec 2024

Can HIIT's metabolic benefits last? New study explores post-exercise sustainability in diabetes

Researchers investigate whether high-intensity interval training-induced metabolic benefits sustain or differ after prolonged training cessation.

9 Dec 2024

Vancouver study reveals surge in severe Shigella cases in homeless population

A recent study published in Clinical Infectious Diseases has uncovered an increase in severe multidrug-resistant (MDR) Shigella sonnei infections, particularly among people experiencing homelessness (PEH) in Vancouver, Canada.

6 Dec 2024

National trial investigates device to restore ovulation in women with PCOS

Physicians at the University of Oklahoma Health Sciences in Oklahoma City are leading a national clinical trial to help women with polycystic ovary syndrome (PCOS)-related infertility who want to become pregnant.

5 Dec 2024

How carrageenan affects insulin resistance

A randomized controlled trial found that carrageenan, a common food additive, may cause subclinical inflammation and insulin resistance in overweight individuals, mediated by gut permeability and inflammation. Effects were linked to BMI but not observed in non-overweight participants during short-term exposure.

3 Dec 2024

Study links menopause hormone therapy to varied heart and blood clot risks

Research on hormone therapy reveals critical insights into cardiovascular disease risks, guiding clinicians in selecting safer treatment options for menopause.

3 Dec 2024

Key risk factors influencing mortality rates in chronic pulmonary aspergillosis patients

A systematic review reveals chronic pulmonary aspergillosis mortality is driven by age and underlying conditions, highlighting the need for targeted therapies.

3 Dec 2024

A roadmap for improving cancer care in South Asia

A series of five papers, published today in The Lancet Oncology by a University of Pittsburgh-led international team, highlights critical public health challenges related to cancer control in the eight countries that form the South Asian Association for Regional Cooperation (SAARC) and the Rohingya refugee population in Bangladesh.

3 Dec 2024

Quabodepistat combo shows promise for safer, faster tuberculosis treatment

Study highlights the safety and early bactericidal activity of quabodepistat when combined with delamanid, bedaquiline, or both, offering potential for shorter and more tolerable tuberculosis treatment regimens.

1 Dec 2024

How genetic traits contribute to earlier diabetes onset and metabolic challenges in South Asians

The study uncovers genetic factors driving early type 2 diabetes in South Asians, highlighting risks of insulin dependence and medication response challenges.

28 Nov 2024

Specific HRT tablets linked to increased risk of heart disease and blood clots

Certain hormone replacement therapy (HRT) tablets containing both estrogen and progestogen are associated with a higher risk of heart disease and rare but serious blood clots known as venous thromboembolism (VTE) in women around the age of menopause, finds a study from Sweden published by The BMJ today.

28 Nov 2024

New HIV prevention injection offers 96% protection

For oral medications that prevent new HIV infection to be effective, the patient must take certain actions, including attending doctor's visits every three months and – most importantly – consistency.

27 Nov 2024