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Research reveals the economic burden of colorectal cancer across Europe

New research led by Queen’s University Belfast has found that colorectal cancer costs Europe a staggering €19.1 billion (£16.3 billion) per year. This figure includes direct expenditure as well as indirect costs including premature death and sick leave.

4 Aug 2021

Inhibition of SARS-CoV-2 replication in vitro by Losartan

A new study explores the use of Losartan to provide protection against COVID-19 pathogenesis.

3 Aug 2021

Social and spatial networks influence the risk of HIV or hepatitis C in people who inject drugs

The risk of HIV or hepatitis C in people who inject drugs is influenced as much by their social interactions and the venues where they inject as other risk factors, according to a study published today in eLife.

3 Aug 2021

Open-access database could speed up repurposing of old drugs as new treatments

Researchers have created a new open-access database of information on drug candidates and how they are metabolized by the body, which could help speed up the repurposing of old drugs as new treatments.

3 Aug 2021

Study finds a significant link between statins and survival rates of triple-negative breast cancer patients

A study led by researchers from The University of Texas MD Anderson Cancer Center found a significant association between cholesterol-lowering drugs commonly known as statins and survival rates of triple-negative breast cancer patients. Since statins are low in cost, easy to access and produce minimal side effects, this could have an important impact on outcomes for this aggressive disease.

3 Aug 2021

What is the potential of microphysiological systems in COVID-19 research?

In a recently published review article in the journal Drug Discovery Today, scientists have described the utility of human-based microphysiological systems MPSs in understanding the pathophysiology of SARS-CoV-2 infection and developing effective therapeutic interventions. Moreover, they have described the establishment of a global working group to synchronize recent developments around MPSs and COVID-19 research.

3 Aug 2021

Research group identifies 15 novel biomarkers linked to late-onset dementias

A study by an international research group identified 15 novel biomarkers that are linked to late-onset dementias. These biomarkers are proteins, which predict cognitive decline and subsequent increased risk of dementia already 20 years before the disease onset.

3 Aug 2021

New breath test to tailor the dosage of drugs administered to epileptic patients

Epilepsy affects some 50 million people worldwide and pharmaceutical treatment of the disease is a tightrope walk, as the dose must be tailored precisely to the individual patient: "Slightly too little and it isn't effective. Slightly too much and it becomes toxic," explains Professor Pablo Sinues.

3 Aug 2021

Antibiotic-resistant salmonella bacteria packs a punch for U.S. travelers

One type of the salmonella bacteria is much more likely to cause disease and fend off frontline antibiotics when acquired in Europe, Asia, and parts of Africa rather than domestically in the United States.

2 Aug 2021

Latin American and Caribbean research contributions to tackle challenges posed by brain diseases

Every year there are nearly ten million new cases of dementia globally, of which Alzheimer's Disease (AD) is the most common form, accounting for around 60-70% of cases.

2 Aug 2021

Existing drug may be effective in treating SARS-CoV-2

Scientists from the University of Chicago have found that the drug masitinib may be effective in treating COVID-19.

2 Aug 2021

Study reveals effective strategy to extend the benefit of immunotherapy for prostate cancer

It's a scientific riddle tangled up in a complex web. How do you turn an immune cold cancer into one that responds to immunotherapy?

2 Aug 2021

Researchers discover titanium oxide nanoparticle that recognizes SARS-CoV-2’s non-structural protein 1

A pioneering study reports on the interaction of a tailored titanium oxide nanoparticle (NP) with the full-length SARS-CoV-2 non-structural protein 1 (nsp1). This should be of value in developing new therapeutic tools against coronaviruses that act by targeting their proteins. It could also help map the structure of activated proteins.

2 Aug 2021

Polyuridine sequence of mouse coronavirus can be targeted to prevent host cell death

A new study reports the use of a modified deoxyribonucleic acid (DNA) oligonucleotide that has a 3’ polyadenine (polyA) tail to bind to the 5’-polyU tract in the mouse coronavirus (MHV-A59). Treatment of mouse cells infected with MHV-A59 with this molecule led to a marked reduction in cell deaths.

2 Aug 2021

Could novel biosensors facilitate SARS-CoV-2 antiviral drug research?

An intriguing new study presents a novel approach to biosensor-based evaluation of promising drugs that could inhibit the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) via its 3C-like protease (3CLpro), a viral protease.

2 Aug 2021

Scientists develop a potent peptide inhibitor of SARS-CoV-2 in vitro

In a recently published article in the journal Drugs in R&D, scientists have described the development and validation of a 13-amino acid peptide inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

2 Aug 2021

SARS-CoV-2 Q493R protein mutation shows resistance to monoclonal antibodies

The Centers for Disease Control and Prevention (CDC) issued a letter detailing a case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in an immunocompromised patient who did not respond well to monoclonal antibody treatment. The resistance to treatment stemmed from an escape mutation on the spike protein known as Q4923R.

2 Aug 2021

Fighting SARS-CoV-2 with nanomedicine

Published in the Journal of Controlled Release, researchers from the German University in Cairo, and the University of Cologne, looked into nano-reformulation of repurposed antiviral and immune-modulating drugs for inhalation therapy against COVID-19. In addition, they focused on how nanomedicine could address the limitations of current therapeutics, enhancing the efficacy, specificity, and safety of such drugs.

1 Aug 2021

Study connects hyperglycemia and prolonged cloth mask use to COVID-19-associated mucormycosis risk

A new study conducted in India identifies the role of high blood sugar levels in predisposing patients to mucormycosis infection.

1 Aug 2021

FDA's accelerated drug approval process plagued by missing efficacy data and questionable evidence

Since the US Food and Drug Administration established its accelerated approval pathway for drugs in 1992, nearly half of the 253 drugs authorized have not been confirmed as clinically effective, an investigation by The BMJ has found.

31 Jul 2021

Drugs News and Research

Research reveals the economic burden of colorectal cancer across Europe

Inhibition of SARS-CoV-2 replication in vitro by Losartan

Social and spatial networks influence the risk of HIV or hepatitis C in people who inject drugs

Open-access database could speed up repurposing of old drugs as new treatments

Study finds a significant link between statins and survival rates of triple-negative breast cancer patients

What is the potential of microphysiological systems in COVID-19 research?

Research group identifies 15 novel biomarkers linked to late-onset dementias

New breath test to tailor the dosage of drugs administered to epileptic patients

Antibiotic-resistant salmonella bacteria packs a punch for U.S. travelers

Latin American and Caribbean research contributions to tackle challenges posed by brain diseases

Existing drug may be effective in treating SARS-CoV-2

Study reveals effective strategy to extend the benefit of immunotherapy for prostate cancer

Researchers discover titanium oxide nanoparticle that recognizes SARS-CoV-2’s non-structural protein 1

Polyuridine sequence of mouse coronavirus can be targeted to prevent host cell death

Could novel biosensors facilitate SARS-CoV-2 antiviral drug research?

Scientists develop a potent peptide inhibitor of SARS-CoV-2 in vitro

SARS-CoV-2 Q493R protein mutation shows resistance to monoclonal antibodies

Fighting SARS-CoV-2 with nanomedicine

Study connects hyperglycemia and prolonged cloth mask use to COVID-19-associated mucormycosis risk

FDA's accelerated drug approval process plagued by missing efficacy data and questionable evidence

Industry Focus eBook - Forensics & toxicology (2nd edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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