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New identified biomarker predicts patients who might benefit from HER2-targeted agents

In an effort to further individualize therapy and avoid over-treating patients, researchers at the Johns Hopkins Kimmel Cancer Center report a new study using PET scans has identified a biomarker that may accurately predict which patients with one type of HER2-positive breast cancer might best benefit from standalone HER2-targeted agents, without the need for standard chemotherapy.

22 Feb 2019

Successful testing of multi-organ "human-on-a-chip" could replace animals as test subjects

The replacement of animals as test subjects is one step closer to reality with the successful testing of multi-organ "human-on-a-chip" models to recapitulate the 28-day experiments typically used in animals to evaluate the systemic toxicity of drug and cosmetic compounds.

22 Feb 2019

Mitochondrial proteotoxicity appears to be epicentre of molecular pathogenesis

Researchers at the University of Helsinki uncovered the mechanisms for a novel cellular stress response arising from the toxicity of newly synthesized proteins.

22 Feb 2019

Intensive therapy during early stages of MS leads to better long-term outcomes

New findings by researchers at Cardiff University suggest that intensive therapy during the early stages of multiple sclerosis (MS) leads to better long-term outcomes for patients, despite it often being viewed as a riskier option than other first-line treatments.

21 Feb 2019

Study quantifies hepatic and intestinal mRNA expression of Ugt isoforms in rats

In pharmaceutical companies, rats are used commonly in nonclinical studies to investigate the safety, efficacy, and pharmacokinetic profiles of drug candidates before they are entered into clinical studies. Most compounds administered via the oral route are metabolized in the liver and intestine, so the metabolism is a key determinant of pharmacokinetics.

20 Feb 2019

Mogrify to accelerate novel IP and cell therapies using $3.7m USD funding

Mogrify today announced a second close on its seed funding, bringing the total raised to $3.7 million USD, and the appointment of Darrin Disley as CEO.

20 Feb 2019

New optimization method rapidly analyzes nanomedicines for cancer treatment

With their ability to treat a wide a variety of diseases, spherical nucleic acids (SNAs) are poised to revolutionize medicine. But before these digitally designed nanostructures can reach their full potential, researchers need to optimize their various components.

20 Feb 2019

Study suggests new treatment strategy for deadly brain cancer

In a study of mice and human brain tumors researchers at the University of the Michigan, Ann Arbor, searched for new treatments by exploring the reasons why some patients with gliomas live remarkably longer than others.

19 Feb 2019

Gene therapy restores hearing in mice with congenital genetic deafness

In collaboration with the universities of Miami, Columbia and San Francisco, scientists from the Institut Pasteur, Inserm, CNRS, Collège de France, Sorbonne University and the University of Clermont Auvergne have managed to restore hearing in an adult mouse model of DFNB9 deafness - a hearing disorder that represents one of the most frequent cases of congenital genetic deafness.

19 Feb 2019

Single CRISPR treatment can safely and stably correct genetic disease

Researchers at Duke University have shown that a single systemic treatment using CRISPR genome editing technology can safely and stably correct a genetic disease -- Duchenne muscular dystrophy (DMD) -- for more than a year in mice, despite observed immune responses and alternative gene editing outcomes.

18 Feb 2019

Immune checkpoint molecule protects against future development of cancer

A research team at the University of Louisville has discovered that an immune checkpoint molecule they developed for cancer immunotherapy, also protects against future development of multiple types of cancer when administered by itself.

15 Feb 2019

Large-scale clinical trial begins to study liver transplantation between people with HIV

The first large-scale clinical trial to study liver transplantation between people with HIV has begun at clinical centers across the United States. The HOPE in Action Multicenter Liver Study will determine the safety of this practice by evaluating liver recipients for potential transplant-related and HIV-related complications following surgery.

15 Feb 2019

Moffitt researchers shed light on how CAR T cells function mechanistically

The scientific community has made great strides over the past decade in the development of a new class of cancer therapy called immunotherapy, a treatment that activates a patient's own immune system to target cancer cells.

15 Feb 2019

Personal, social factors play role in enabling sustainable return to work after ill health

Support from managers and colleagues, as well as a positive attitude, are most likely to enable a more long-term return to work for employees after a sickness absence, according to a new review of research led by the University of East Anglia.

15 Feb 2019

Researchers conduct extensive comparison of drugs used in treating neuroendocrine tumors

An increasing number of new anti-cancer drugs are made available each year. During the authorization process, such new drugs usually undergo comparisons to one, but only rarely to multiple established drugs.

14 Feb 2019

FDA warns doctor for illegally marketing unapproved implantable device

Today, the U.S. Food and Drug Administration issued a warning letter to Mark Berman, M.D., of Beverly Hills, California, for illegally marketing an unapproved implantable device, the Pocket Protector, that Dr. Berman claims can prevent and treat a complication of breast implants known as capsular contracture, or tightening of scar tissue.

14 Feb 2019

Depression prevention for pregnant women and new mothers – new recommendations

At present all new mothers are screened for symptoms of depression and help is provided to those who need care. The U.S. Preventive Services Task Force now has urged doctors to screen pregnant women for risks of depression and provide adequate counselling and support to prevent the onset of depression after delivery. The report was published in the Journal of the American Medical Association this week.

14 Feb 2019

Study aims to customize epilepsy treatment by stimulating the brain non-invasively

Stimulating the brain with implanted electrodes is a successful, but very drastic measure. Researchers from Eindhoven University of Technology, Kempenhaeghe, Philips and Gent University will therefore be working on a method to stimulate the brain using electrodes that are placed on the head rather than inside it.

13 Feb 2019

Research reveals critical immunological axis that triggers cancer-promoting chronic inflammation

A Massachusetts General Hospital research team has identified interaction between two elements of the immune system as critical for the transformation of a protective immune response into chronic, cancer-promoting inflammation.

12 Feb 2019

New PET imaging agent may help measure efficacy or failure of hormone therapy for breast cancer

Physicians may soon have a new way to measure the efficacy or failure of hormone therapy for breast cancer patients, according to new research published in the February issue of The Journal of Nuclear Medicine.

12 Feb 2019

Efficacy News and Research

New identified biomarker predicts patients who might benefit from HER2-targeted agents

Successful testing of multi-organ "human-on-a-chip" could replace animals as test subjects

Mitochondrial proteotoxicity appears to be epicentre of molecular pathogenesis

Intensive therapy during early stages of MS leads to better long-term outcomes

Study quantifies hepatic and intestinal mRNA expression of Ugt isoforms in rats

Mogrify to accelerate novel IP and cell therapies using $3.7m USD funding

New optimization method rapidly analyzes nanomedicines for cancer treatment

Study suggests new treatment strategy for deadly brain cancer

Gene therapy restores hearing in mice with congenital genetic deafness

Single CRISPR treatment can safely and stably correct genetic disease

Immune checkpoint molecule protects against future development of cancer

Large-scale clinical trial begins to study liver transplantation between people with HIV

Moffitt researchers shed light on how CAR T cells function mechanistically

Personal, social factors play role in enabling sustainable return to work after ill health

Researchers conduct extensive comparison of drugs used in treating neuroendocrine tumors

FDA warns doctor for illegally marketing unapproved implantable device

Depression prevention for pregnant women and new mothers – new recommendations

Study aims to customize epilepsy treatment by stimulating the brain non-invasively

Research reveals critical immunological axis that triggers cancer-promoting chronic inflammation

New PET imaging agent may help measure efficacy or failure of hormone therapy for breast cancer

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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