Preclinical News and Research

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Medarex announces preliminary data for investigational anti-PD-1 antibody

Medarex, Inc. has announced preliminary data from an ongoing Phase 1 study of MDX-1106 (ONO-4538: development code of Ono Pharmaceutical Co., Ltd.), a fully human anti-PD-1 antibody.

2 Jun 2008

Researchers pinpoint gene mutations responsible for 10 percent of non-familial cases of schizophrenia

Scans of the genome of patients with schizophrenia have revealed rare spontaneous copy number mutations that account for at least 10 percent of the non-familial cases of the disease.

1 Jun 2008

Fireflies' glow helps researchers track cancer drug's effectiveness

The gene that allows fireflies to flash is helping researchers track the effectiveness of anti-cancer drugs over time.

29 May 2008

First patient enrolled in phase III study of Bevacizumab and Trastuzumab in early breast cancer

A new international study for women with HER2-positive breast cancer is open for enrollment. The pivotal BETH (BEvacizumab and Trastuzumab Adjuvant Therapy in HER2-positive Breast Cancer) study is a Phase III clinical research trial that is investigating the benefits of combining two monoclonal antibodies, the anti-angiogenic, bevacizumab (Avastin) and the targeted therapy trastuzumab (Herceptin), together with chemotherapy for the treatment of patients with early stage HER2-positive breast cancer.

27 May 2008

Chemically modified protein may help people with hard-to-treat hemophilia

Pathologists at The University of Texas Health Science Center at Houston have developed a chemically modified protein that may help people with a hard-to-treat form of a genetic bleeding disorder known as Hemophilia A. The discovery and the results of pre-clinical tests appear in the May 2 issue of the Journal of Biological Chemistry.

19 May 2008

Cancer drug shows promise as treatment for pulmonary hypertension

A drug developed to fight cancer is showing early promise as a treatment for pulmonary hypertension, researchers from the University of Chicago Medical Center report May 19 at the American Thoracic Society International Conference in Toronto, Canada.

19 May 2008

Cancer Research UK and AstraZeneca announce innovative deal for promising anti-cancer compound

Cancer Research UK and Cancer Research Technology (CRT) - the charity's development and commercialisation arm - today announced an innovative new arrangement to progress into clinical development a potential anti-cancer compound from AstraZeneca.

19 May 2008

Pfizer and Peter MacCallum support the future of cancer research in Australia

Australia's reputation for excellence in cancer research has been strengthened with the launch of the Peter MacCallum Pfizer Translational Oncology Research Collaborative Hub (TORCH) at the Peter MacCallum Cancer Centre, by the Minister for Innovation, Industry, Science and Research, Senator the Hon. Kim Carr.

18 May 2008

DNA vaccines boosted by dendritic cells

The concept sounds ideal: vaccines made of DNA that could be taken in by other cells and give instructions for how to fight off different diseases. The reality, however, has fallen short. Although DNA vaccines have been around for about 15 years and shown lots of promise for HIV, SARS and influenza vaccines during preclinical testing in mice, researchers have yet to make them potent enough to be helpful in humans.

18 May 2008

microRNAs provide more clues to genetics of schizophrenia

Researchers at Columbia University Medical Center have illuminated a window into how abnormalities in microRNAs, a family of molecules that regulate expression of numerous genes, may contribute to the behavioral and neuronal deficits associated with schizophrenia and possibly other brain disorders.

11 May 2008

Cytopia announces novel anti-cancer drug development collaboration

Cytopia Limited today announced that it has entered into an anti-cancer drug discovery and development collaboration with Cancer Therapeutics CRC Pty Ltd. This agreement leverages Cytopia's early stage drug discovery pipeline of kinase inhibitors, a class of targeted therapeutics that is one of the fastest growing segments of the cancer drug market.

9 May 2008

Patent claims allowed covering Samaritan's Alzheimer's memory recovery drug in Australia

Samaritan Pharmaceuticals, a biopharmaceutical company committed to commercializing new innovative therapeutic drugs, has received notification that the claims in the patent application for "Neuroprotective Spirostenol Pharmaceutical Compositions" covering Caprospinol (SP-233) have been allowed by the Australian Patent Office.

6 May 2008

Geron Corporation awarded UK grant funding for human embryonic stem cell research

Geron Corporation announced today two grant awards to the University of Edinburgh from the UK Stem Cell Foundation, with funding from the Medical Research Council and Scottish Enterprise.

6 May 2008

Prana Biotechnology has discovered novel drug candidates for use in Parkinson's disease

Prana Biotechnology Limited has announced that it has identified novel therapeutic drug candidates from its Parkinson's disease program. Already, a lead candidate drug has demonstrated positive effects in pre-clinical studies, protecting the brain from damage to the substantia nigra, the area of the brain affected in Parkinson's disease.

6 May 2008

Drug candidate to treat smallpox scaled up by new partnership

Two American companies are teaming up for second-round test-phase production of a FDA-designated "fast track" drug candidate to treat smallpox, a deadly virus that is feared to be able to reach people through acts of bio-warfare or bio-terrorism.

5 May 2008

Anti-HIV NanoViricide drug candidate shows promise in animal trials

NanoViricides, Inc said that its anti-HIV drug candidates demonstrated significant therapeutic efficacy in the recently completed preliminary animal studies.

5 May 2008

U-M receives grant to provide free and open, online health professions educational materials

The University of Michigan has launched an ambitious pilot project to make comprehensive pre-clinical health curricula available worldwide via the Internet.

1 May 2008

ImmunoVaccine Technologies patents DepoVax vaccine platform

ImmunoVaccine Technologies Inc. (IVT), a vaccine development company, unveiled today its DepoVax platform, a novel depot vaccine delivery system used to increase the efficacy and strength of vaccines. IVT has filed additional patents to protect the DepoVax concept.

30 Apr 2008

Gene therapy restores vision in patients with rare congenital blindness

In a clinical trial at The Children's Hospital of Philadelphia, researchers from The University of Pennsylvania have used gene therapy to safely restore vision in three young adults with a rare form of congenital blindness.

27 Apr 2008

Biopharmaceutical spin-out company Domainex, secures funding

Headquartered in London, Domainex is a contract research company specialising in the provision of structural biology and chemistry services to major pharmaceutical and biotechnology firms. The Company is also developing a pipeline of pre-clinical drugs and targets.

From Domainex 23 Apr 2008

Preclinical News and Research

Medarex announces preliminary data for investigational anti-PD-1 antibody

Researchers pinpoint gene mutations responsible for 10 percent of non-familial cases of schizophrenia

Fireflies' glow helps researchers track cancer drug's effectiveness

First patient enrolled in phase III study of Bevacizumab and Trastuzumab in early breast cancer

Chemically modified protein may help people with hard-to-treat hemophilia

Cancer drug shows promise as treatment for pulmonary hypertension

Cancer Research UK and AstraZeneca announce innovative deal for promising anti-cancer compound

Pfizer and Peter MacCallum support the future of cancer research in Australia

DNA vaccines boosted by dendritic cells

microRNAs provide more clues to genetics of schizophrenia

Cytopia announces novel anti-cancer drug development collaboration

Patent claims allowed covering Samaritan's Alzheimer's memory recovery drug in Australia

Geron Corporation awarded UK grant funding for human embryonic stem cell research

Prana Biotechnology has discovered novel drug candidates for use in Parkinson's disease

Drug candidate to treat smallpox scaled up by new partnership

Anti-HIV NanoViricide drug candidate shows promise in animal trials

U-M receives grant to provide free and open, online health professions educational materials

ImmunoVaccine Technologies patents DepoVax vaccine platform

Gene therapy restores vision in patients with rare congenital blindness

Biopharmaceutical spin-out company Domainex, secures funding

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