Apoptosis News and Research

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Apoptosis is programmed cell death, the body's normal method of disposing of damaged, unwanted, or unneeded cells.

Bayreuth researchers discover natural protective mechanism against cancer

Susanne Hellmuth and Olaf Stemmann from the Chair of Genetics at the University of Bayreuth have discovered a natural protective mechanism that leads to the programmed death of potentially diseased cells.

23 Apr 2020

Combinations of PAC and WFA are highly synergistic against proliferation of non-small cell lung cancer

Oncotarget Volume 11 Issue 16 showed that the sensitivity of H1299 and A549 cells to concomitant treatment with PAC and WFA was greater than that of either PAC or WFA alone.

23 Apr 2020

Radiation therapy plays a crucial role in management of OPSCC

HPV-negative UM-SCC4 with and without transfection of HPV E6 oncoprotein, HPV-negative UPCI-SCC-089, and HPV-positive UPCI-SCC-099 cell lines were used in this study.

22 Apr 2020

Difference between flu and novel coronavirus disease

Both influenza and COVID-19 disease are caused by infectious respiratory agents and cause symptoms that can look quite similar. Coronaviruses cause both. So, what’s the difference?

21 Apr 2020

A new combinatorial therapy for treatment of liver cancer

In the latest issue of Molecular Therapy, Skoltech and MIT researchers have published a new combinatorial therapy for the treatment of liver cancer.

20 Apr 2020

World's largest protein connection map reveals cell workings

The human body is comprised of billions of cells. Yet it functions and grows as a single organism, because of trillions of interactions that help various cells recognize and respond to each other via different molecules on their surface or inside the cells. Now, a new study published in the journal Nature in April 2020 describes the first-ever interactome map, to help distinguish healthy interactions and disease-producing ones.

8 Apr 2020

Researchers develop a unique radiochemical synthesis approach for treating cancer

Radiolabeled molecules, so-called radiotracers, help nuclear physicians to detect and precisely target tumors, which are often developing due to pathological changes in metabolic processes.

7 Apr 2020

Researchers find direct link between MCL1 protein and cell-cycle checkpoint protein

Human cells respond to stresses like DNA damage, metabolic imbalance and starvation by first trying to repair the problem.

5 Apr 2020

New molecular mechanism that regulates the sentinel cells of the immune system

A study suggests that it may be possible to regulate macrophages with drugs that modulate the nuclear receptor RXR.

3 Apr 2020

Physical activity beneficial for mental well-being in middle-aged women despite menopausal status

A recent study has found that late menopausal status is associated with an elevated level of depressive symptoms that indicate the negative dimension of mental well-being.

1 Apr 2020

Rheumatism: New clues about the prevalence of certain genetic profile in Europeans

A piece of research by the Human Evolutionary Biology Group at the UPV/EHU-University of the Basque Country provides clues about the prevalence of a certain genetic profile in the European population.

27 Mar 2020

New approach shows promise as a treatment for chemo-resistant ovarian cancer

Researchers have made a discovery about the behavior of ovarian cancer cells that could lead to a new treatment approach.

27 Mar 2020

Scientists uncover key molecular mechanism underlying different aspects of sepsis

Sepsis is a life-threatening condition that kills millions annually; it is poorly understood and has no specific treatment.

27 Mar 2020

Researchers uncover molecular link between trans fats and variety of disorders

Tohoku University researchers in Japan have uncovered a molecular link between some trans fats and a variety of disorders, including cardiovascular and neurodegenerative diseases.

25 Mar 2020

YAP signal pathway plays a vital role in the onset of head-and-neck cancer

Joint research between Kobe University and National Hospital Organization Kyushu Cancer Center has revealed that mice with mutations in the YAP signal pathway develop head-and-neck cancer over an extremely short period of time (world's fastest cancer onset mouse model), indicating that this pathway plays a crucial role in the onset of these cancers.

25 Mar 2020

A review of the literature on acute promyelocytic leukemia

Oncotarget Volume 11, Issue 11 reported that relapsed APL, particularly in the high-risk subset of patients, remains an important clinical problem.

22 Mar 2020

Changes in cellular degradation hubs can lead to cancer

A team of scientists at Uppsala University has revealed that alterations in cells’ lysosomes underly abnormal cell growth.

17 Mar 2020

Antioxidant treatment in acute ischemic stroke could delay onset of clinically overt dementia

Currently we are facing a dementia epidemic, with estimations showing that by 2050 approximately 131 million people will be affected.

17 Mar 2020

Trial of cancer drug OxaliTex promises lower toxicity and more robust action

Preclinical trials indicate that a drug candidate called OxaliTex can stop the growth of cancer cells completely. OxaliTex appears to be more potent than many other common chemotherapy drugs, with less toxicity and less rapidly counteracted by mechanisms of drug resistance. The study was reported in the journal Proceedings of the National Academy of Sciences in March 2020.

16 Mar 2020

MicroRNA dysregulation has critical impacts on development, inflammation and cancer development

Oncotarget Volume 11, Issue 10 reported that dysregulation of noncoding micro RNA molecules has been associated with immune cell activation in the context of Helicobacter pylori-induced gastric inflammation as well as carcinogenesis, but also with downregulation of mismatch repair genes, and may interfere with immune checkpoint proteins that lead to the overexpression of antigens on gastric tumor cells.

13 Mar 2020

Apoptosis News and Research

Bayreuth researchers discover natural protective mechanism against cancer

Combinations of PAC and WFA are highly synergistic against proliferation of non-small cell lung cancer

Radiation therapy plays a crucial role in management of OPSCC

Difference between flu and novel coronavirus disease

A new combinatorial therapy for treatment of liver cancer

World's largest protein connection map reveals cell workings

Researchers develop a unique radiochemical synthesis approach for treating cancer

Researchers find direct link between MCL1 protein and cell-cycle checkpoint protein

New molecular mechanism that regulates the sentinel cells of the immune system

Physical activity beneficial for mental well-being in middle-aged women despite menopausal status

Rheumatism: New clues about the prevalence of certain genetic profile in Europeans

New approach shows promise as a treatment for chemo-resistant ovarian cancer

Scientists uncover key molecular mechanism underlying different aspects of sepsis

Researchers uncover molecular link between trans fats and variety of disorders

YAP signal pathway plays a vital role in the onset of head-and-neck cancer

A review of the literature on acute promyelocytic leukemia

Changes in cellular degradation hubs can lead to cancer

Antioxidant treatment in acute ischemic stroke could delay onset of clinically overt dementia

Trial of cancer drug OxaliTex promises lower toxicity and more robust action

MicroRNA dysregulation has critical impacts on development, inflammation and cancer development

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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