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Phase 1 clinical studies reveal safety, tolerability of therapeutic vaccine in celiac disease patients

ImmusanT, Inc., a clinical-stage company developing Nexvax2, a therapeutic vaccine intended to protect against the effects of gluten exposure while maintaining a gluten-free diet in HLA-DQ2.5+ patients with celiac disease, today announced the publication of positive data from two Phase 1 clinical trials of Nexvax2 in celiac disease.

12 May 2017

Introduction of ART has increased life expectancy in HIV patients by 10 years

A study published in the journal The Lancet HIV has found an increase in life expectancy of 20-year-old HIV patients in the EU and North America who had started antiretroviral therapy (ART) after it was introduced mid-1990s. When compared with patients who were not treated with ART, the life expectancy had increased by around a decade in these patients.

11 May 2017

Researchers find new way to prevent graft-versus-host disease after stem cell transplants

Through experimental work, an international team of researchers led by City of Hope's Defu Zeng, professor of diabetes immunology and hematopoietic cell transplantation, believe they may have found a way to prevent graft-versus-host disease after stem cell transplants while retaining the transplants' positive effects on fighting leukemia and lymphoma.

18 Apr 2017

Positive emotion intervention improves health in people newly diagnosed with HIV

When individuals recently diagnosed with HIV were coached to practice skills to help them experience positive emotions, the result was less HIV in their blood and lower antidepressant use, reports a new Northwestern Medicine study.

17 Apr 2017

Th17 cell durability offers promise for next-generation adoptive cancer immunotherapy trials

Medical University of South Carolina investigators report that long-term expansion protocols for adoptive cancer immunotherapy do not compromise Th17 cells' effectiveness against large tumors, in the March 9, 2017 issue of JCI Insight.

17 Apr 2017

TSRI scientists find new way to make cell population resistant to HIV

Scientists at The Scripps Research Institute have found a way to tether HIV-fighting antibodies to immune cells, creating a cell population resistant to the virus.

11 Apr 2017

Research unravels how cytokines prevent multi-organ damage during parasitic infection

Cytokines are proteins secreted by several types of immune cells in response to infection, inflammation, or injury. Interleukin-17 (IL-17) is one such cytokine that causes inflammation, by controlling the production of other cytokines and mobilizing a type of white blood cell (neutrophil) that fights infections.

3 Apr 2017

Researchers shed light on how immune cells weaken with age

Researchers from the European Bioinformatics Institute, University of Cambridge, the Wellcome Trust Sanger Institute and the Cancer Research UK–Cambridge Institute have shed light on a long-standing debate about why the immune system weakens with age.

3 Apr 2017

City of Hope researchers to highlight basic cancer research and population studies at AACR meeting

City of Hope, a world-renowned independent research and cancer and diabetes treatment center, will highlight a variety of basic research and population studies at the annual meeting of the American Association for Cancer Research at the Walter E. Washington Convention Center in Washington, D.C., April 1 to 5.

28 Mar 2017

One-shot vaccine passes key preclinical test in newborn monkey models

Newborns are highly vulnerable to infections and don't respond optimally to most vaccines because their young immune systems typically mount weak antibody responses.

24 Mar 2017

Penn researcher receives $16.3 million NIAID grant to develop long-sought-after HIV vaccine

Building on earlier work in designing chimeric human-simian immunodeficiency viruses (SHIVs) that serve as a model of HIV infection of humans, George M. Shaw, MD, PhD, a professor of Hematology/Oncology and Microbiology in the Perelman School of Medicine at the University of Pennsylvania, has received $16.3 million over five years from the National Institute of Allergy and Infectious Diseases to develop a long-sought-after HIV vaccine.

22 Mar 2017

CD4+ T-cell count may not be helpful to assess ART response in HTLV-1/HIV co-infected patients

The authors compared the CD4+ T-cell counts and HIV-1 RNA viral loads of 383 patients who were either mono-infected with HIV or co-infected with HTLV-1/HIV.

17 Mar 2017

Researchers uncover mechanism that contributes to joint inflammation in rheumatoid arthritis patients

New research findings published in the Journal of Leukocyte Biology, suggest that synovial CD4+ T cells that produce IL-21 contribute to joint inflammation by activating synovial fibroblasts in rheumatoid arthritis patients.

2 Mar 2017

Activated T-cells promote heart failure after heart attack

Chronic inflammation after a heart attack can promote heart failure and death. University of Alabama at Birmingham researchers have now shown that activated T-cells — part of the immune system's inflammatory response — are both necessary and sufficient to produce such heart failure.

28 Feb 2017

Only subset of mother's HIV virus infects infants during pregnancy or breastfeeding, research shows

In the transmission of HIV-1 from mother to child only a subset of a mother's viruses infects their infants either in utero or via breastfeeding, and the viruses that are transmitted depend on whether transmission occurs during pregnancy or through breastfeeding, according to UCLA-led research.

15 Feb 2017

CD4 News and Research

Phase 1 clinical studies reveal safety, tolerability of therapeutic vaccine in celiac disease patients

Introduction of ART has increased life expectancy in HIV patients by 10 years

Researchers find new way to prevent graft-versus-host disease after stem cell transplants

Positive emotion intervention improves health in people newly diagnosed with HIV

Th17 cell durability offers promise for next-generation adoptive cancer immunotherapy trials

TSRI scientists find new way to make cell population resistant to HIV

Research unravels how cytokines prevent multi-organ damage during parasitic infection

Researchers shed light on how immune cells weaken with age

City of Hope researchers to highlight basic cancer research and population studies at AACR meeting

One-shot vaccine passes key preclinical test in newborn monkey models

Penn researcher receives $16.3 million NIAID grant to develop long-sought-after HIV vaccine

CD4+ T-cell count may not be helpful to assess ART response in HTLV-1/HIV co-infected patients

Researchers uncover mechanism that contributes to joint inflammation in rheumatoid arthritis patients

Activated T-cells promote heart failure after heart attack

Only subset of mother's HIV virus infects infants during pregnancy or breastfeeding, research shows

New Zika vaccine candidate shows potential to protect against virus with single dose

UAB researchers find how gut fails to prevent HIV-1 infection

New genital herpes vaccine candidate shows promising results in preclinical tests

Research findings could lead to development of novel therapeutic approaches against viral infections

Researchers identify sub-population of HIV-1 strains with biological properties to transmit new infections

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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