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Brazilian professors propose guidelines for therapeutic use of melatonin

Sixty years after melatonin was isolated and with more than 23,000 published studies showing the many functions of this hormone secreted by the pineal gland, guidelines should be discussed and established for its therapeutic use.

11 Dec 2018

Gut bacteria may modify effectiveness of anti-diabetes drugs

Why do orally-administered drugs for diabetes work for some people but not others? According to researchers at Wake Forest School of Medicine, bacteria that make up the gut microbiome may be the culprit.

11 Dec 2018

Deadly combination: Drug cocktail induces cancer cell death by switching off energy supply

A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth - this was discovered by researchers from the University of Basel's Biozentrum two years ago. In a follow-up study, recently published in Cell Reports, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.

11 Dec 2018

Research findings could lead to new targets for cancer-fighting therapeutics

A molecular pathway that's frequently mutated in many different forms of cancer becomes active when cells push parts of their membranes outward into bulging protrusions, Johns Hopkins researchers report in a new study.

11 Dec 2018

Researchers uncover a number of previously unknown insecticide resistance mechanisms

Researchers at LSTM have used a bioinformatics approach to integrate information from multiple studies on insecticide resistance in mosquitoes and uncovered a number of important resistance mechanisms that had not previously been recognized.

11 Dec 2018

Experts address sleep disorders following traumatic brain injury

Disorders of sleep are some of the most common problems experienced by patients after traumatic brain injury. It is important to recognize and treat these problems early to allow for optimal cognitive recovery, but because they are so common, the importance of treating them is often underestimated.

10 Dec 2018

High-intensity interval exercise could help combat cognitive dysfunction in obese people

It's fast-paced, takes less time to do, and burns a lot of calories. High-intensity interval exercise is widely recognized as the most time-efficient and effective way to exercise.

10 Dec 2018

Risk Analysis publishes special issue on communicating about Zika virus

Today, Risk Analysis, an International Journal, published a special issue, "Communicating About Zika," which features several articles that were originally presented as works-in-progress at the Zika Communication Summit convened in March 2017 by the Annenberg Public Policy Center of the University of Pennsylvania.

10 Dec 2018

Study: Drug reduces hot flash frequency, improves quality of life in breast cancer survivors

Research led by oncologists Roberto Leon-Ferre, M.D. and Charles Loprinzi, M.D. of Mayo Clinic has found that the drug oxybutynin helps to reduce the frequency and intensity of hot flashes in women who are unable to take hormone replacement therapy, including breast cancer survivors.

7 Dec 2018

VCU researchers test vaccine against opioid abuse

Virginia Commonwealth University researchers are testing a vaccine against opioid abuse developed by the Scripps Research Institute in California. The vaccine is meant to block the effects of heroin and fentanyl in patients with opioid use disorder.

7 Dec 2018

Researchers aim to demystify bladder immunity

We know that the bladder is a poorly understood organ, critical for storing metabolic waste. What we don’t know is how this unique environment impacts bladder immunity to common diseases such as urinary tract infections and bladder cancer.

6 Dec 2018

Spinal cord injury disrupts the body's internal clock, study shows

Although paralysis is the most noticeable result of a spinal cord injury, a new study by researchers at The University of Texas at Austin suggests such injuries could throw off the internal clock of the entire body's daily activities, from hormones to sleep-wake schedules.

6 Dec 2018

Bacterial infections may contribute to far more cancers than previously thought, shows study

The Institute of Human Virology at the University of Maryland School of Medicine announced today the discovery that DnaK, a protein of the bacterium mycoplasma, interferes with the mycoplasma-infected cell's ability to respond to and repair DNA damage, a known origin of cancer.

5 Dec 2018

Physician-scientists present updated efficacy data on CAR T-cell gene immunotherapy

Physician-scientists from Children's Hospital of Philadelphia presented updated efficacy and safety data on Kymriah--the first-ever U.S. Food and Drug Administration approved personalized CAR T-cell gene immunotherapy for aggressive blood cancers at the 60th American Society of Hematology annual meeting, as well as first-of-its-kind research on overcoming CAR T-cell resistance.

5 Dec 2018

Spaceflight does not compromise major part of the immune system, shows research

With a new crew arriving at the International Space Station, astronauts will be relieved to know that they won't have to worry about a major aspect of their immune system being compromised.

5 Dec 2018

New vaccine candidate for Zika virus proves to be effective in mice and monkeys

Researchers at the University of Hawaii medical school have successfully developed a vaccine candidate for the Zika virus, showing that it is effective in protecting both mice and monkeys from the infection.

5 Dec 2018

ACR and NPF release joint treatment guideline for psoriatic arthritis

The American College of Rheumatology and National Psoriasis Foundation have released a joint treatment guideline for psoriatic arthritis that provides evidence-based pharmacologic and non-pharmacologic recommendations on caring for treatment-naïve patients with active PsA and patients who continue to have active PsA despite treatment.

4 Dec 2018

New study launched in Burkina Faso to test typhoid conjugate vaccine

A new study has been launched in Burkina Faso for Bharat Biotech's typhoid conjugate vaccine. It is the second clinical study underway in Africa for the vaccine and the first in West Africa.

4 Dec 2018

New strategies may improve performance of CAR-T cell therapy in treating cancer

Mayo Clinic researchers have developed two new strategies that may improve the performance of chimeric antigen receptor therapy in treating cancer. They are presenting results of their preclinical research at the 2018 annual meeting of the American Society of Hematology in San Diego.

3 Dec 2018

People with epilepsy who live in high-crime neighborhoods experience more seizures

People with epilepsy living in high crime neighborhoods in Chicago had three times as many seizures as those living in neighborhoods with lower crime rates according to new research from the University of Illinois at Chicago presented at the American Epilepsy Society 2018 conference in New Orleans.

3 Dec 2018