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Potentially serious side effect reported after CAR-T cell therapy for multiple myeloma

Mount Sinai scientists have become the first to report a potentially serious side effect related to a new form of immunotherapy known as CAR-T cell therapy, which was recently approved for the treatment of multiple myeloma.

11 Dec 2021

Machine-learning model could help identify treatments that pose higher risk than other options

Sepsis claims the lives of nearly 270,000 people in the U.S. each year. The unpredictable medical condition can progress rapidly, leading to a swift drop in blood pressure, tissue damage, multiple organ failure, and death.

11 Dec 2021

Indication of minor added benefit of nivolumab for adjuvant treatment of esophageal cancer

In an early benefit assessment, the German Institute for Quality and Efficiency in Health Care investigated whether nivolumab has an added benefit over watchful waiting in the adjuvant treatment of adults with carcinoma of the esophagus or the gastroesophageal junction and pathological residual disease after prior neoadjuvant chemoradiotherapy (CRT).

10 Dec 2021

NRG Oncology CC004 trial: Bupropion does not improve sexual desire for female cancer survivors

Despite preliminary supporting evidence that the dopaminergic agent bupropion might improve sexual desire for female cancer survivors, the NRG Oncology CC004 clinical trial determined that bupropion did not improve outcomes when compared to a placebo.

10 Dec 2021

New insights about COVID-19 vaccination rates among people living with HIV

The AIDS Clinical Trials Group, the largest global HIV research network, which recently expanded its focus to include evaluating outpatient treatment for COVID-19, today announced that insights around COVID-19 vaccination rates among people living with HV have been published in the Journal of Infectious Diseases.

10 Dec 2021

Viruses do not lead to new antibiotic resistance, can be our allies in defeating pathogenic bacteria

Viruses may sometimes be our enemies, but they can also be our allies. When our medicines are no longer effective, viruses can be valuable partners in defeating pathogenic bacteria.

10 Dec 2021

Study measures arterial stiffness in women from wide age range

A study conducted at the University of Jyväskylä in the Faculty of Sport and Health Sciences measured arterial stiffness in women from wide age range.

10 Dec 2021

Subcutaneous defibrillators equally effective in delivering electric shocks, study says

Electric shocks delivered by subcutaneous defibrillators are equally effective compared to shocks delivered by conventional transvenous defibrillators, according to a study published in the journal Circulation.

9 Dec 2021

Online single-session interventions help curb teen depression, study shows

A study of more than 2,400 adolescents ages 13 to 16 shows two online, single-session interventions designed to help curb teen depression works, a tool very much needed given a rise in teen depression and loss of some in-person mental health services during the Covid-19 pandemic.

9 Dec 2021

Johns Hopkins astrophysicist receives Life Sciences 2021 award for novel cancer mapping technology

Johns Hopkins astrophysicist, Alexander Szalay, Ph.D., and Kimmel Cancer Center pathologist Janis Taube, M.D., M.Sc., received a Life Sciences 2021 award for AstroPath at this year's Falling Walls Science Summit, an international event honoring research breakthroughs from across the globe.

9 Dec 2021

New consensus-based recommendations designed to improve quality of life for DMD patients

Many more adults with Duchenne muscular dystrophy (DMD) are living longer thanks to improvements in treatment, however international standards of care have not yet fully addressed the complex needs of these patients.

9 Dec 2021

Study could aid in the development of adaptive DBS treatments for obsessive-compulsive disorder

In a small study, researchers funded by the National Institutes of Health captured more than 1,000 hours of brain recordings from patients with OCD in the clinic and at home.

9 Dec 2021

Prescribing generic heart medications in Medicare Part D could result in substantial savings

Prescribing generic medications for heart and blood vessel diseases more frequently instead of brand-name medications in Medicare's prescription drug program, called Part D, could save more than $600 million each year in the U.S., according to new research published today in Circulation: Cardiovascular Quality and Outcomes, an American Heart Association journal.

9 Dec 2021

Biologic agent dupilumab effective in improving asthma exacerbations and lung function, study shows

A new medication has been added to the treatment options for children with moderate-to-severe asthma. In a late-stage clinical trial, the biologic agent dupilumab reduced the rate of severe asthma attacks and improved lung function and asthma control for children ages 6 to 11.

9 Dec 2021

Gene therapy and diabetes drug may be treatments for late-onset retinal degeneration

Scientists have discovered that gene therapy and the diabetes drug metformin may be potential treatments for late-onset retinal degeneration (L-ORD), a rare, blinding eye disease.

9 Dec 2021

Effect of SARS-CoV-2 variant emergence on efficacy of neutralizing antibodies and vaccines

A review article focuses on the efficacy of neutralizing antibodies and vaccines against the SARS-CoV-2 variants.

9 Dec 2021

Immune responses against SARS-CoV-2 Delta variant after BNT162b2 vaccination in people living with HIV

Researchers from Sorbonne Universite have been investigating the effect of the BNT162b2 mRNA vaccine on HIV-positive individuals.

9 Dec 2021

High-dose intravenous iron reduces heart attacks in hemodialysis patients

A new paper in Cardiovascular Research, published by Oxford University Press, indicates that iron treatments may reduce heart attacks in patients experiencing kidney failure undergoing dialysis.

8 Dec 2021

Study shows how senescent cells can be an underlying cause of kidney damage

A study in mice by researchers at Georgetown Lombardi Comprehensive Cancer Center has found that stress and tissue damage initiated by angiotensin II, a molecule that is known to increase blood pressure and stiffening in the linings of blood vessels, leads to cellular senescence, a process by which a cell ages and permanently stops dividing but does not die.

8 Dec 2021

CRISPR/Cas9 gene editing enables sonodynamic therapy to effectively shrink tumors

Sonodynamic therapy uses ultrasound in combination with drugs to release harmful reactive oxygen species (ROS) at the site of a tumor.

8 Dec 2021

Therapy News and Research

Potentially serious side effect reported after CAR-T cell therapy for multiple myeloma

Machine-learning model could help identify treatments that pose higher risk than other options

Indication of minor added benefit of nivolumab for adjuvant treatment of esophageal cancer

NRG Oncology CC004 trial: Bupropion does not improve sexual desire for female cancer survivors

New insights about COVID-19 vaccination rates among people living with HIV

Viruses do not lead to new antibiotic resistance, can be our allies in defeating pathogenic bacteria

Study measures arterial stiffness in women from wide age range

Subcutaneous defibrillators equally effective in delivering electric shocks, study says

Online single-session interventions help curb teen depression, study shows

Johns Hopkins astrophysicist receives Life Sciences 2021 award for novel cancer mapping technology

New consensus-based recommendations designed to improve quality of life for DMD patients

Study could aid in the development of adaptive DBS treatments for obsessive-compulsive disorder

Prescribing generic heart medications in Medicare Part D could result in substantial savings

Biologic agent dupilumab effective in improving asthma exacerbations and lung function, study shows

Gene therapy and diabetes drug may be treatments for late-onset retinal degeneration

Effect of SARS-CoV-2 variant emergence on efficacy of neutralizing antibodies and vaccines

Immune responses against SARS-CoV-2 Delta variant after BNT162b2 vaccination in people living with HIV

High-dose intravenous iron reduces heart attacks in hemodialysis patients

Study shows how senescent cells can be an underlying cause of kidney damage

CRISPR/Cas9 gene editing enables sonodynamic therapy to effectively shrink tumors

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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