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Patients who undergo Fontan surgery for congenital heart defect have liver fibrosis risk, study reveals

Patients who undergo the Fontan operation as children for a complex congenital heart defect are at risk of developing progressive liver fibrosis, a buildup of fibrous deposits, as a result of the circulation created by the surgery, according to a new study.

31 May 2017

TSRI professor receives $2 million grant to study neurofibromatosis type I

Assistant Professor Seth Tomchik of the Florida campus of The Scripps Research Institute (TSRI) has received $2 million in funding from the National Institutes of Health's National Institute of Neurological Disorders and Stroke.

31 May 2017

Collaborative effort to develop rare disease patient registries

The Orphan Disease Center in the Perelman School of Medicine at the University of Pennsylvania will collaborate with Pulse Infoframe Inc., a medical informatics company, to develop rare disease patient registries aimed at enabling international collaboration to better understand these diseases, as well as accelerate and improve clinical studies to develop new therapies.

31 May 2017

Therapeutic small molecules safely prevent blood clots without excessive bleeding

It may be possible to disrupt harmful blood clots in people at risk for heart attack or stroke without increasing their risk of bleeding, according to a new study published in Nature Communications.

31 May 2017

Case Western Reserve University awarded $6 million grant to continue research on Barrett's Esophagus

The National Cancer Institute recently awarded a $6 million grant to the Case Comprehensive Cancer Center and Case Western Reserve University School of Medicine to continue research on Barrett's Esophagus, a potentially fatal condition caused by long-term acid reflux.

31 May 2017

Short-term functional high-intensity training may improve beta-cell function in adults with type 2 diabetes

A new study finds that short, functional-movement and resistance training workouts, called functional high-intensity training (F-HIT), may improve beta-cell function in adults with type 2 diabetes.

31 May 2017

Nearly half of adults with mood disorders experience chronic pain, survey finds

In a survey of adults with anxiety or a mood disorder like depression or bipolar disorder, about half reported experiencing chronic pain, according to researchers at Columbia University's Mailman School of Public Health.

31 May 2017

MGH scientists show how Shigella survives journey from mouth to the colon

Surviving the treacherous journey through the human body from the mouth to the colon takes a special kind of bacterial pathogen.

31 May 2017

Study: Men's lower resting heart rate explains higher rate of criminal offending

In the field of criminology, it is well established that men engage in more crime than women. Now, a new study from the University of Pennsylvania published in the journal Criminology, addresses the incomplete understanding of why males are more criminal than females by examining gender differences in biological functioning and behavior.

31 May 2017

Brain changes after stroke may lead to increased preference for alcohol, research suggests

Brain changes after stroke may lead to increase in alcohol-seeking behavior, at least in animal models, according to research published Wednesday in the journal Scientific Reports.

31 May 2017

New chartbook illustrates burden of chronic illnesses

A new publication illustrates the burden that chronic illnesses impose on American society, demonstrating through charts and graphics how 60 percent of American adults suffer from at least one chronic health condition and 42 percent have more than one.

31 May 2017

Study sheds light on mechanisms that maintain gene activity in embryonic stem cells

Researchers from Turku, Finland, have discovered new information about the mechanisms which maintain gene activity in human embryonic stem cells.

31 May 2017

Nitrogen oxide emissions from traffic higher than previously thought

In metropolitan areas throughout Europe maximum permissible values of nitrogen oxide are consistently breached. It has been a challenge to determine how much each polluter contributes to the emission output.

31 May 2017

Internet withdrawal causes physiological changes in digitally-dependent people

Scientists and clinicians from Swansea and Milan have found that some people who use the internet a lot experience significant physiological changes such as increased heart rate and blood pressure when they finish using the internet.

31 May 2017

Combined modality treatment provides alternative to complete bladder removal for patients with MIBC

A meta-analysis of previously published cancer research showed no difference in five-year and 10-year survival rates between patients who underwent radical cystectomy, which is the surgical removal of the bladder, and a bladder-preserving combined modality treatment (CMT) plan, which combines radiation therapy, chemotherapy and the removal of the bladder tumor.

31 May 2017

Combining oral drug with personalized cell therapy can lead to complete remission in CLL patients

Combining the kinase inhibitor ibrutinib with an investigational personalized cellular therapy known as CTL119 can lead to complete remission in patients with high-risk chronic lymphocytic leukemia (CLL), according to new research from the Perelman School of Medicine at the University of Pennsylvania and Penn's Abramson Cancer Center

31 May 2017

Study shows how hyperglycemia following surgery for PAD affects post-surgical outcomes

High blood sugar, also known as hyperglycemia, occurs when the body does not produce enough insulin to turn blood glucose into energy.

31 May 2017

TB germs' metabolic 'escape pathways' may be neutralized by new drugs to shorten duration of therapy

New research suggests the bacteria that cause tuberculosis alter their metabolism to combat exposure to antimicrobials, and that these metabolic "escape pathways" might be neutralized by new drugs to shorten the troublesome duration of therapy.

31 May 2017

New study documents prevalence of food allergies

Anecdotal evidence of food allergies abounds, but just how common are these allergies and intolerances? In a new study, investigators from Brigham and Women's Hospital combed through medical records from more than 2.7 million patients, identifying more than 97,000 with one or more documented food allergy or intolerance.

31 May 2017

Researchers make significant advance in treatment of bowel cancer

New research led by Queen's University Belfast has discovered how a genomic approach to understanding bowel (colorectal) cancer could improve the prognosis and quality of life for patients.

31 May 2017

Research News and Research

Patients who undergo Fontan surgery for congenital heart defect have liver fibrosis risk, study reveals

TSRI professor receives $2 million grant to study neurofibromatosis type I

Collaborative effort to develop rare disease patient registries

Therapeutic small molecules safely prevent blood clots without excessive bleeding

Case Western Reserve University awarded $6 million grant to continue research on Barrett's Esophagus

Short-term functional high-intensity training may improve beta-cell function in adults with type 2 diabetes

Nearly half of adults with mood disorders experience chronic pain, survey finds

MGH scientists show how Shigella survives journey from mouth to the colon

Study: Men's lower resting heart rate explains higher rate of criminal offending

Brain changes after stroke may lead to increased preference for alcohol, research suggests

New chartbook illustrates burden of chronic illnesses

Study sheds light on mechanisms that maintain gene activity in embryonic stem cells

Nitrogen oxide emissions from traffic higher than previously thought

Internet withdrawal causes physiological changes in digitally-dependent people

Combined modality treatment provides alternative to complete bladder removal for patients with MIBC

Combining oral drug with personalized cell therapy can lead to complete remission in CLL patients

Study shows how hyperglycemia following surgery for PAD affects post-surgical outcomes

TB germs' metabolic 'escape pathways' may be neutralized by new drugs to shorten duration of therapy

New study documents prevalence of food allergies

Researchers make significant advance in treatment of bowel cancer

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