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Use of positron emission tomography may eliminate more strenuous drug development trials with animals

A number of articles explore the use of positron emission tomography (PET) and small animal imaging—nonsurgical techniques that open the door to understanding and treating human diseases—in the April issue of the Society of Nuclear Medicine’s Journal of Nuclear Medicine.

26 Apr 2005

Fickle enzyme helps protect, but also can promote heart failure

Enzymes that make the gas nitric oxide (NO) not only protect the heart from damage due to high blood pressure or a heart attack, but also promote heart failure through overgrowth and enlargement of the muscle tissue, say animal researchers at Johns Hopkins.

26 Apr 2005

Antibody for West Nile virus shows promise

Researchers have developed an antibody that can cure mice of West Nile virus (WNV) infection, a disease for which no specific treatment exists, the National Institute of Allergy and Infectious Diseases (NIAID) has announced.

25 Apr 2005

Gene therapy for Alzheimer's disease shows promise

In the first clinical trial of gene therapy for Alzheimer's disease researchers have produced preliminary evidence that gene therapy may slow the decline in mental functioning associated with Alzheimer's disease.

25 Apr 2005

Despite knowledge, very few follow a healthy lifestyle

New research has shown that despite access to advice on healthy lifestyles and government campaigns to encourage people to adopt a healthier way of life, very few Americans are applying that knowledge to themselves.

25 Apr 2005

New statin study shows arrested progression of atherosclerosis

The first study to use cutting edge magnetic resonance imaging to examine the effect of a statin - rosuvastatin (Crestor) - on the fatty plaques in arteries, was presented yesterday at the 75th European Atherosclerosis Society Congress. ORION revealed that rosuvastatin has a beneficial effect on the size and composition of fatty plaques in arteries (specifically the carotid artery in the neck). Fatty plaques that are vulnerable to sudden rupture can cause heart attacks and strokes without warning.

25 Apr 2005

Substantially more effective therapy than current treatments for Alzheimer's disease

PET scans and cognitive tests have suggested that Alzheimer's disease patients with genetically modified tissue inserted directly into their brains show a reduction in the rate of cognitive decline and increased metabolic activity in the brain, according to a study published in the April 24, 2005 online issue of the journal Nature Medicine by researchers at the University of California, San Diego (UCSD) School of Medicine.

25 Apr 2005

Increased risk associated with combining carotid artery, coronary artery surgeries

Among patients undergoing evaluation for coronary artery bypass surgery, stroke neurologists are frequently consulted when the patient also has severe carotid artery stenosis (blockage of an artery that supplies blood to the brain).

25 Apr 2005

Important new finding about the brain and its stem cells

A family's bravery and generosity in the face of their son's death three years ago has enabled researchers to make an important new finding about the brain and its stem cells.

25 Apr 2005

Study sheds light on why normal prion proteins may experience age-related mutations in inherited diseases

A new study sheds light on why normal prion proteins may experience age-related mutations in inherited diseases. Researchers at the Case Western Reserve University School of Medicine studied a previously discovered mutation in the prion protein in members of an extended family in Indiana who inherited the prion disease Gerstmann-Straussler-Sheinker (GSS).

25 Apr 2005

Few US adults report having a healthy lifestyle

Despite clear evidence of the health benefits, few U.S. adults conform to four common healthy behaviors that together characterize a healthy lifestyle, according to the April 25 issue of Archives of Internal Medicine.

25 Apr 2005

Chest x-rays may provide information to help detect osteoporosis in the elderly

Undetected osteoporosis in the elderly might be discovered if chest radiographs (x-ray images) that are done for other reasons were examined for fractures of the vertebrae, according to an article in the April 25 issue of Archives of Internal Medicine.

25 Apr 2005

Risk scores may identify young individuals with atherosclerosis

Young people with atherosclerotic lesions may be identified by a risk score calculated from coronary heart disease factors like obesity, sex, age, cholesterol, and smoking, according to an article in the April 25 issue of Archives of Internal Medicine.

25 Apr 2005

Increasing benefit seen in novel drug AMN107, that treats Gleevec resistance

An investigational drug is producing powerful responses in patients resistant to Gleevec, the targeted therapy that helps most people diagnosed with chronic myeloid leukemia (CML), an international research team headed by investigators at The University of Texas M. D. Anderson Cancer Center is reporting.

23 Apr 2005

Ensuring patient safety at fertility clinics

In the years since the birth of the first ‘test-tube’ baby in 1978, in-vitro fertilisation (IVF) has grown to become an accepted mainstream medical technique, with more than 25,000 treatments carried out every year.

23 Apr 2005

Drinking wine or beer has same result: higher blood pressure

Whether the drink of choice is a frosty beer or a full-bodied red wine, the effect is the same – higher blood pressure, according to research reported in Hypertension: Journal of the American Heart Association.

23 Apr 2005

Enlarged waist + elevated triglycerides = heart, stroke risks for women

A tape measure and a simple blood test may be the best way to gauge cardiovascular risk for postmenopausal women, according to a report published today in an obesity-themed issue of Circulation: Journal of the American Heart Association.

23 Apr 2005

International internet drug ring shattered

Drug Enforcement Administration (DEA) Administrator Karen P. Tandy has announced the results of Operation “Cyber Chase”, a year-long Organized Crime Drug Enforcement Task Force (OCDETF) investigation that targeted international Internet pharmaceutical traffickers operating in the United States, India, Asia, Europe and the Caribbean. These e-traffickers distributed drugs world-wide using “rogue” Internet pharmacies.

23 Apr 2005

Pfizer recalls epilepsy medicine

Pfizer has voluntarily recalled one lot (40,000 bottles) of 100 mg capsules of its epilepsy medication, Neurontin, after a manufacturing mechanical failure resulted in some bottles containing empty or partially filled capsules.

23 Apr 2005

Canadian Diabetes Association, UBC partner on funding for childhood diabetes research

A new partnership announced by the Canadian Diabetes Association and the University of British Columbia (UBC) will help fund research in childhood diabetes. Not only will this research further investigate type 1 diabetes, it will also explore the areas of type 2 diabetes and obesity in children, a problem of growing concern and proportions.

23 Apr 2005