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Alternate view for pathology of Alzheimer's disease

A new paper from researchers at the Case Western Reserve University School of Medicine challenges the classic theory that the nerve tangles seen in the brains of Alzheimer's disease (AD) victims are the cause of the disease, but rather proposes that they are a protective response to the disease. Their paper appears in the April issue of the journal Trends in Molecular Medicine.

19 Apr 2005

Australian researchers develop safer and more effective aspirin

Monash University researchers and staff of the Melbourne-based biotechnology company Cerylid Biosciences Ltd, have discovered and developed a new class of anti-clotting drugs that appears to be more effective than aspirin at preventing disease-causing blood clots and has fewer side effects.

19 Apr 2005

Researchers determine structure of binding site of colon-cancer drug Erbitux and its protein target

Researchers at the University of Pennsylvania School of Medicine have determined the precise molecular details of how Erbitux, a recently approved colorectal cancer drug, binds to its target on cancer cells. Knowing this chemical configuration will lead to better drug design for this family of cancer medications.

19 Apr 2005

Alcohol-impaired driving increases significantly

A national survey has found that after a long, slow downward trend alcohol-impaired driving has recently increased significantly. From 1993 to 1997 the estimated annual number of episodes of alcohol-impaired driving (AID) declined at a rate of a little more than one percent per year, from 123 million to 116 million. From 1997 to 1999, however, it increased 37 percent, from 116 million to 159 million. It stayed at that increased rate in 2002.

19 Apr 2005

Link between insomnia and obesity

A possible link between lack of sleep (insomnia) and obesity has been traced to hypocretin/orexin cells in the hypothalamus region of the brain that are easily excited and sensitive to stress, Yale School of Medicine researchers report in the April issue of Cell Metabolism.

13 Apr 2005

History of preeclampsia increases lifetime risk for cardiovascular illness and death

In a study of mothers with a history of preeclampsia, a hypertension complication in pregnancy affecting five percent of all women, researchers at Yale have found that these women have an increased lifetime risk for cardiovascular illness and death.

13 Apr 2005

Researchers show why mutations in a certain few genes, such as the p53 tumor suppressor gene, are found in different cancers

Scientists have identified some of the first genetic triggers for cancer as mutations in specific oncogenes or tumor suppressor genes. Full-blown tumors and metastatic cancers, however, often exhibit many genetic mutations, sometimes dozens in a given tumor. An important scientific question, and one with significant clinical implications, has been what happens after the initial mutation that leads to dangerous later-stage cancers with multiple damaged genes.

13 Apr 2005

Scientists have discovered the mechanism that enables some CD4 T cells - the main target of HIV - to thwart the virus

The discovery, reported on April 13 in the online version of Nature, could open the door to an entirely new strategy for preventing the spread of HIV infection in the body's cells, according to the senior author of the study, Gladstone Institute of Virology and Immunology Director Warner C. Greene, MD, PhD.

13 Apr 2005

Neurologists may have foot in the door to preventing Alzheimer’s before it starts

A study led by Mayo Clinic shows for the first time that a drug appears to have a slowing effect -- though limited -- on the progression from mild cognitive impairment to Alzheimer's disease. The findings will be published online in the New England Journal of Medicine on April 14.

13 Apr 2005

Common genetic mutation that increases the risk of inheriting Hirschsprung disease

Gene hunters at Johns Hopkins have discovered a common genetic mutation that increases the risk of inheriting a particular birth defect not by the usual route of disrupting the gene's protein-making instructions, but by altering a regulatory region of the gene. Although the condition, called Hirschsprung disease, is rare, its complex genetics mimics that of more common diseases, such as diabetes and heart disease.

13 Apr 2005

Clinical diagnosis of Alzheimer's may be delayed

In a study of people with mild cognitive impairment (MCI), those who took the drug donepezil were at reduced risk of progressing to a diagnosis of Alzheimer's disease (AD) during the first year of the trial, but by the end of the 3-year study there was no benefit from the drug. Vitamin E was also tested in the study and was found to have no effect at any time point in the study when compared with placebo.

13 Apr 2005

New heart valve ring helps congestive heart failure patients regain lost heart function

A new heart valve ring appears to help congestive heart failure patients regain lost heart function, reversing the disease's effects on heart structure in two ways and easing their disabling symptoms, researchers reported here today at the 85th Annual Meeting of the American Association for Thoracic Surgery.

13 Apr 2005

Scientists use transcription factors to increase insulin production in diabetic mice

A group of Japanese scientists has used gene therapy to deliver three insulin transcription factors, MafA, PDX-1, and NeuroD, to the livers of diabetic mice. As a result, the mice experienced an increase in insulin gene expression and insulin production, raising the possibility that this could eventually be used to treat diabetes.

13 Apr 2005

First large study defining premature ejaculation by stopwatch and patient reported outcomes

In a four-week study of 1,587 men, researchers report that men who suffer from premature ejaculation (PE) had an average intravaginal ejaculatory latency time (IELT) of 1.8 minutes, compared to 7.3 minutes in men who did not. Men with PE and their female partners also had higher ratings for personal distress, interpersonal difficulty with their partner, lack of ejaculation control, and dissatisfaction with sexual intercourse.

13 Apr 2005

Scientists identifiy protein that seems to control the malignant features of brain tumor cells

Scientists from Wake Forest University School of Medicine have identified a protein that seems to control the malignant features of brain tumor cells, suggesting a new treatment target for anti-cancer drugs. The research is reported in the current issue of Molecular Cancer Research.

13 Apr 2005

Bugs in the gut could help doctors develop individualised healthcare

The success of personalised healthcare hinges on a better understanding of how microbes in the gut interact with different medicines report scientists from Imperial College London and Astra Zeneca.

13 Apr 2005

Black women in the US less likely to access preventative cancer treatments

A report from the University of Pennsylvania School of Medicine in Philadelphia says that black women in the US with a family history of breast or ovarian cancer, are far less likely to seek genetic counselling and possible testing than their white counterparts, and although the reasons for the disparity are not clear, it is suspected that mistrust of both the medical system and advice from primary physicians may be factors.

12 Apr 2005

Technology helps Stanford shed new light on coronary bypass surgery

On March 31, Joel Dyels celebrated his 72nd birthday by having coronary bypass surgery at Stanford Hospital. He also became the third patient at Stanford - and in the United States - to benefit from a new imaging system that lets doctors see the blood pathways they have created while the patient's chest is still open.

12 Apr 2005

Grandmother smoking can cause childrens asthma

Scientists from the University of Southern California are saying that smoking could have a longer-lasting impact on families' health than ever before realised.

12 Apr 2005

Fish and soy oil help keep hearts healthy

Researchers say that older people who take a daily fish or soy oil supplement can reduce their risk of developing irregular heart rhythm or sudden cardiac death.

12 Apr 2005

Medicine News and Research

Alternate view for pathology of Alzheimer's disease

Australian researchers develop safer and more effective aspirin

Researchers determine structure of binding site of colon-cancer drug Erbitux and its protein target

Alcohol-impaired driving increases significantly

Link between insomnia and obesity

History of preeclampsia increases lifetime risk for cardiovascular illness and death

Researchers show why mutations in a certain few genes, such as the p53 tumor suppressor gene, are found in different cancers

Scientists have discovered the mechanism that enables some CD4 T cells - the main target of HIV - to thwart the virus

Neurologists may have foot in the door to preventing Alzheimer’s before it starts

Common genetic mutation that increases the risk of inheriting Hirschsprung disease

Clinical diagnosis of Alzheimer's may be delayed

New heart valve ring helps congestive heart failure patients regain lost heart function

Scientists use transcription factors to increase insulin production in diabetic mice

First large study defining premature ejaculation by stopwatch and patient reported outcomes

Scientists identifiy protein that seems to control the malignant features of brain tumor cells

Bugs in the gut could help doctors develop individualised healthcare

Black women in the US less likely to access preventative cancer treatments

Technology helps Stanford shed new light on coronary bypass surgery

Grandmother smoking can cause childrens asthma

Fish and soy oil help keep hearts healthy

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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