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Leti's New Deal project could revolutionize IBD therapies for great benefit of patients in the European Union

Leti, a technology research institute of CEA Tech, today announced a European Union project to develop a nanotherapy targeting the molecules involved in inflammatory bowel diseases (IBD), such as Crohn’s disease and ulcerative colitis.

12 May 2017

People with severe mental illness have higher risk for cardiovascular disease, study reveals

An international study of more than 3.2 million people with severe mental illness reveals a substantially increased risk for developing cardiovascular disease compared to the general population.

12 May 2017

Phase 1 trial shows safety and tolerability of oncolytic HSV-1 for children, young adults with cancer

HSV1716 – an oncolytic herpes simplex virus-1 – has been studied in adults via injection into the brain and superficial tumors.

11 May 2017

Research findings identify protein as potential new drug target for HCMV infections

Scientists have demonstrated that a human protein known as valosin containing protein (VCP) is essential for replication of human cytomegalovirus. The findings, published in PLOS Pathogens, identify VCP as a potential new treatment target.

11 May 2017

Preclinical data reinforces potential efficacy, durability of investigational gene therapy for DMD

Solid Biosciences announced today that new data from two preclinical studies reinforce the potential of its investigational microdystrophin gene therapy, SGT-001, to be an effective treatment approach for Duchenne muscular dystrophy.

11 May 2017

Study reveals how proline metabolism supports breast cancer metastasis

A multinational group of scientists, led by professor Sarah-Maria Fendt, have discovered that breast cancer cells that have invaded other organs rely on a different nutrient metabolism to produce energy than normal cells and non-metastasizing cancer cells.

11 May 2017

Researchers discover dual-functional compound that shows potential to combat type 1, type 2 diabetes

According to research published online in The FASEB Journal, scientists have discovered a dual peptide called "PGLP-1" that promotes insulin secretion and inhibits gluconeogenesis.

11 May 2017

Improper methylation of cilia protein linked to increased risk of neural tube defects

Research published online in The FASEB Journal shows that the improper methylation of a protein called "Septin2," which regulates the structure of cilia, was associated with an increased risk of having a neural tube defect (NTD) and confirms that cilia are important factors in determining susceptibility of NTDs.

11 May 2017

Study shows link between susceptibility to malignant hyperthermia and exertional heat stroke

New research published online in The FASEB Journal may ultimately help athletes and trainers better understand who may be more at risk for heat stroke.

11 May 2017

Suppression of thyroid hormone receptor protects cone cells in mouse models of retinal diseases

New research published online in The FASEB Journal suggests that the suppression of thyroid hormone receptor activity locally in the retina protects cone photoreceptor cells in mouse models of human retinal degenerative diseases

11 May 2017

Research explores effect of alcohol on adolescent brain

Under 18, no alcohol. In spite of this slogan, adolescents still have access to alcohol. But how harmful is that one beer for the adolescent brain? Research, including in Leiden, may provide the answer.

11 May 2017

Researchers identify microRNA biomarker linked to incidence of atrial fibrillation

Researchers have identified a microRNA biomarker that demonstrates a strong association with the incidence of atrial fibrillation, the most common abnormal heart rhythm that affects more than 2.7 million Americans.

11 May 2017

Children born with small or missing eyes benefit from personalized treatment using 3D-printed implants

A new, personalized and noninvasive treatment using 3-D printed implants has been developed to help children born with abnormally small or missing eyes.

11 May 2017

New research sheds light on inner mechanisms underlying learning and memory

New research published online in The FASEB Journal sheds important light on the inner workings of learning and memory.

11 May 2017

Research lays groundwork to develop realistic ‘biomimetic neuroprosthetics’

By applying a novel computer algorithm to mimic how the brain learns, a team of researchers – with the aid of the Comet supercomputer based at the San Diego Supercomputer Center at UC San Diego and the Center's Neuroscience Gateway – has identified and replicated neural circuitry that resembles the way an unimpaired brain controls limb movement.

11 May 2017

Exposure to flower pesticides affects neurobehavioral performance in children

Ecuador is the third largest producer of cut flowers in the world, primarily roses, many of which are destined to be sold for Mother's Day. The industry employs more than 103,000 people, and relies heavily on agricultural pesticides.

11 May 2017

Preclinical results of translational research show favorable outcomes in developing Zika virus vaccine

Preclinical results of research by City College of New York scientists and TechnoVax, Inc. in animal models demonstrate favorable outcomes in developing a vaccine against the mosquito-borne Zika virus.

11 May 2017

Large source of real-time data provides insight into treatment for vision-threatening condition

For most people, being nearsighted is a nuisance, easily treated with a prescription for glasses or contact lenses. But some experience a complication that can cause permanent blindness.

11 May 2017

Mild blast-induced concussion can lead to worse outcomes in military service members, study finds

According to a new study in JAMA Neurology, U.S. military service members who endured a mild concussion after blast injury while deployed in Iraq or Afghanistan may continue to experience mental health symptoms as well as decreases in quality of life for at least five years after their injury.

11 May 2017

Chemical stimuli by small molecule can improve production of cartilage cells

Cell-based therapies could offer a way to treat cartilage injuries before the ultimate damage of osteoarthritis on articular cartilage.

11 May 2017

Research News and Research

Leti's New Deal project could revolutionize IBD therapies for great benefit of patients in the European Union

People with severe mental illness have higher risk for cardiovascular disease, study reveals

Phase 1 trial shows safety and tolerability of oncolytic HSV-1 for children, young adults with cancer

Research findings identify protein as potential new drug target for HCMV infections

Preclinical data reinforces potential efficacy, durability of investigational gene therapy for DMD

Study reveals how proline metabolism supports breast cancer metastasis

Researchers discover dual-functional compound that shows potential to combat type 1, type 2 diabetes

Improper methylation of cilia protein linked to increased risk of neural tube defects

Study shows link between susceptibility to malignant hyperthermia and exertional heat stroke

Suppression of thyroid hormone receptor protects cone cells in mouse models of retinal diseases

Research explores effect of alcohol on adolescent brain

Researchers identify microRNA biomarker linked to incidence of atrial fibrillation

Children born with small or missing eyes benefit from personalized treatment using 3D-printed implants

New research sheds light on inner mechanisms underlying learning and memory

Research lays groundwork to develop realistic ‘biomimetic neuroprosthetics’

Exposure to flower pesticides affects neurobehavioral performance in children

Preclinical results of translational research show favorable outcomes in developing Zika virus vaccine

Large source of real-time data provides insight into treatment for vision-threatening condition

Mild blast-induced concussion can lead to worse outcomes in military service members, study finds

Chemical stimuli by small molecule can improve production of cartilage cells

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