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CCTA identifies more patients with coronary artery disease

Coronary CT angiography (CCTA) scans allow doctors to determine safely and more quickly which patients at low-to intermediate-risk for a heart attack can be discharged from hospital emergency departments (EDs) than traditional methods, according to the results of a large, multicenter American College of Radiology Imaging Network (ACRIN) trial published online today in the New England Journal of Medicine.

26 Mar 2012

Synthetic pasta-like objects are major chemistry advances for regenerative medicine

Medicine's recipe for keeping older people active and functioning in their homes and workplaces - and healing younger people injured in catastrophic accidents - may include "noodle gels" and other lab-made invisible filaments that resemble uncooked spaghetti with nanoscale dimensions, a scientist said here today at the 243rd National Meeting & Exposition of the American Chemical Society (ACS).

26 Mar 2012

Largest study to date to look at BMC therapy in patients with heart failure

Use of a patient's bone marrow cells for treating chronic ischemic heart failure did not result in improvement on most measures of heart function, according to a study appearing in JAMA. The study is being published early online to coincide with its presentation at the American College of Cardiology's annual scientific sessions.

26 Mar 2012

High-fat, low-carb foods linked with increased risk of heart attack in obese people

High-fat, low-carb foods are a popular choice for dieters, but new laboratory research by University of Alabama at Birmingham cardiologists indicates these may be detrimental to the health of people who have ischemic cardiovascular disease or a predisposition to heart attacks.

26 Mar 2012

Study validates Mitofusin 2 as possible target for treatment of diabetes mellitus

Researchers at the Institute for Research in Biomedicine (IRB Barcelona) have discovered that deficiency of a single protein, Mitofusin 2, in muscle and hepatic cells of mice is sufficient to cause tissues to become insensitive to insulin, thus producing an increase in blood glucose concentrations. These are the two most common conditions prior to development of diabetes type 2.

26 Mar 2012

NSBRI, NASA's Johnson Space Center extend cooperative agreement

NASA's Johnson Space Center has awarded a five-year, $120 million extension of its cooperative agreement with the National Space Biomedical Research Institute, or NSBRI, of Houston.

26 Mar 2012

Real-time, non-invasive test to detect heart attack

What if your doctor could tell you in real-time, with a non-invasive test as to whether or not you might be having an acute myocardial infarction (AMI) or in simpler terms, a heart attack?

23 Mar 2012

Deficiency of Mitofusin 2 protein leads to insulin resistance, glucose intolerance

The study shows that the lack of Mitofusin 2 in mice produces insulin resistance and glucose intolerance, the main causes of diabetes.

23 Mar 2012

FDA clears multiple enhancements to St. Jude Medical's FFR measurement guidewire

St. Jude Medical, Inc., a global medical device company, today announced it has received U.S. Food and Drug Administration (FDA) clearance for multiple enhancements to its PressureWire Fractional Flow Reserve (FFR) measurement guidewire.

23 Mar 2012

No added benefit of aliskiren-amlodipine fixed drug combination for hypertension

The fixed drug combination of aliskiren and amlodipine (trade name: Rasilamlo-) was approved in April 2011 for the treatment of people with hypertension in whom aliskiren or amlodipine alone has an insufficient effect.

23 Mar 2012

Long daily sedentary periods cause a health risk despite physical activity

Good physical condition is a route to better health, and in order to improve it, exercising several days a week is recommended. Although it is possible to become healthier by exercising, long daily sedentary periods cause a health risk despite physical activity.

23 Mar 2012

Intensive exercise routines astronauts during long-duration spaceflights

Astronauts have been taking part in short spaceflight missions since 1961. They have only recently begun to spend significantly longer times in space, with missions extending for months, since the days of the Russian Mir space station (1986-2001) and extended stays on the International Space Station.

23 Mar 2012

Verapamil drug may reverse diabetes-related death of pancreatic beta cells

A common high-blood-pressure medication appears to reverse the diabetes-related death of pancreatic beta cells, according to a University of Alabama at Birmingham study published today in the journal Diabetes.

23 Mar 2012

No added benefit from retigabine therapy in adults with epileptic seizures

The drug retigabine was approved in March 2011 as add-on therapy for adults with epileptic seizures. In an early benefit assessment pursuant to the "Act on the Reform of the Market for Medicinal Products" (AMNOG), the German Institute for Quality and Efficiency in Health Care (IQWiG) examined whether retigabine offers an added benefit compared with the present standard therapy.

23 Mar 2012

Towards a more comprehensive view of brain-hand relationship

Research at Arizona State University and Columbia University to better understand the intricate sensory and cognitive connections between the brain and the hands has won support from the National Science Foundation. New discoveries about such connections could benefit people with neurological disorders such as Parkinson's disease and cerebral palsy, and those who need prosthetic hands.

22 Mar 2012

Researchers explain how obscurins suppress breast cancer formation

A new discovery published online in The FASEB Journal may lead to a new tool to help physicians assess breast cancer risk as well as diagnose the disease. In the report, researchers from Johns Hopkins University and the University of Maryland, explain how proteins, called "obscurins," once believed to only be in muscle cells, act as "tumor suppressor genes" in the breast.

22 Mar 2012

EMS responders can play a significant role in reducing MCTB time for STEMI patients

Health care practitioners have long understood the importance of "door to balloon" time for heart attack patients-the faster they can get the patient from the door of the hospital to a catheterization lab to open a clogged artery, the better the patient will do.

22 Mar 2012

Researchers identify mechanism involved in positioning nuclei in muscle fibres

In order to move, living beings need muscles, and, more specifically, skeletal muscles that are controlled by the nervous system. Skeletal muscles are composed of cylindrical muscle fibres with a multitude of peripheral nuclei. Until now, little was known about the mechanism used to position nuclei on the edge of muscle fibres. A team of French-American researchers has tried to better understand the reasons behind nuclei layout.

21 Mar 2012

TACT believes that Halo's HT-100 may effectively treat DMD

Halo Therapeutics, LLC, a clinical-stage biopharmaceutical company developing novel therapeutics for rare fibrotic diseases, announced today that the TREAT-NMD Advisory Committee on Therapeutics (TACT) has reviewed HT-100, Halo's drug candidate for Duchenne muscular dystrophy (DMD), and believes the compound has potential based on the proposed mechanism.

21 Mar 2012

Cardium commences Generx Phase 3 registration study in myocardial ischemia

Cardium Therapeutics today announced the initiation of the ASPIRE Phase 3 registration study to evaluate the therapeutic effects of Cardium's lead product candidate, Generx (Ad5FGF-4) in patients with myocardial ischemia.

21 Mar 2012