Antidepressant News and Research

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Antidepressants are medicines that treat depression. Your doctor can prescribe them for you. They can improve your mood, sleep, appetite and concentration. It may take several weeks for them to help. There are several types of antidepressants. You and your doctor may have to try several before finding what works best for you.

LED light instantly triggers or reverses depression-like behavior in rodents

A specific pattern of neuronal firing in a brain reward circuit instantly rendered mice vulnerable to depression-like behavior induced by acute severe stress, a study supported by the National Institutes of Health has found. When researchers used a high-tech method to mimic the pattern, previously resilient mice instantly succumbed to a depression-like syndrome of social withdrawal and reduced pleasure-seeking - they avoided other animals and lost their sweet tooth.

13 Dec 2012

AZD6765 briefly improves treatment-resistant patients' depression symptoms in minutes

A drug that works through the same brain mechanism as the fast-acting antidepressant ketamine briefly improved treatment-resistant patients' depression symptoms in minutes, with minimal untoward side effects, in a clinical trial conducted by the National Institutes of Health. The experimental agent, called AZD6765, acts through the brain's glutamate chemical messenger system.

13 Dec 2012

Takeda, Lundbeck announce FDA acceptance of vortioxetine NDA submission

Takeda Global Research & Development Center, Inc., (Takeda) and H. Lundbeck A/S (Lundbeck) jointly announced today that the U.S. Food and Drug Administration (FDA) has accepted for filing their submission of a New Drug Application (NDA) for vortioxetine for the treatment of major depressive disorder (MDD) in adult patients.

13 Dec 2012

Novel antidepressant targets brain receptors responsible for learning and memory

A first-of-its-kind antidepressant drug discovered by a Northwestern University professor and now tested on adults who have failed other antidepressant therapies has been shown to alleviate symptoms within hours, have good safety and produce positive effects that last for about seven days from a single dose.

7 Dec 2012

CBT may help reduce depression in people who have not responded to antidepressants

For the first time in a large-scale randomised trial, scientists have demonstrated that people with depression who have not responded to treatment with antidepressants are three times more likely to get better if they receive cognitive behavioural therapy (CBT) in addition to antidepressants and usual care.

7 Dec 2012

Naurex reports positive results from GLYX-13 Phase IIa trial on depression

Naurex Inc., a clinical-stage company developing innovative treatments to address unmet needs in psychiatry and neurology, today reported positive results from a Phase IIa clinical trial of its lead antidepressant compound, GLYX-13.

6 Dec 2012

Antidepressants in normal dosage may positively impact mood and seizure frequency

Epilepsy and depression are common co-morbidities. Concern for the potential of certain antidepressants to induce seizures has led to under-treating depression and anxiety disorders in epilepsy patients. Research presented today at the 66th American Epilepsy Society meeting suggests that antidepressants in normal dosage may have a positive impact on both mood and seizure frequency.

4 Dec 2012

Certain SSRI medications fail to achieve same selectivity for prevention of SUDEP

Scientists from Southern Illinois University today reported the results of a study evaluating the potential effect of two selective serotonin reuptake inhibitors (SSRI) antidepressant medications in reducing the risk of sudden unexpected death in epilepsy (SUDEP).

4 Dec 2012

Suicide ‘a major concern’ in childhood psychosis

Children and adolescents with a first episode of psychosis should be monitored closely for suicidal behavior, say researchers who found that more than 12% of such patients attempted suicide over a 24-month period.

29 Nov 2012

Subthreshold bipolarity common in major depressive disorder

Results from a Polish study show that a substantial proportion of patients with major depressive disorder meet criteria for subthreshold bipolarity.

27 Nov 2012

Holiday healthy eating reminders from Greenwich Hospital

As holiday crunch time fills your schedule, don't give up your exercise. "When times get crazy, the thing people give up is exercise, and that's the key thing a person needs. When a person is excitable from stress, the burst of energy that you get from exercise can help burn the adrenaline off and calm you down," said Erica Christ, RD, CDE, an exercise physiologist at Greenwich Hospital's Weight Loss & Diabetes Center.

22 Nov 2012

Sharp decline in ECT availability and use in the U.S. general hospitals

Electroconvulsive therapy (ECT) is considered the most effective treatment option for patients with severe depression who cannot find symptom relief through antidepressant medications or psychotherapy. In a new study, researchers at Butler Hospital and Bradley Hospital in Rhode Island found a sharp decline in the availability and use of ECT in general hospitals across the U.S.

21 Nov 2012

Gene variants involved in glutamatergic transmission appear to increase risk of depression

Researchers using a new approach to identifying genes associated with depression have found that variants in a group of genes involved in transmission of signals by the neurotransmitter glutamate appear to increase the risk of depression.

14 Nov 2012

Controlling depression can improve health status and social functioning in patients with heart failure

Controlling depression in patients with heart failure can improve health status, social functioning and quality of life, according to a new study by psychiatrists and cardiologists at the UC Davis and Duke University schools of medicine.

1 Nov 2012

SSRIs should be prescribed with great caution to those attempting to get pregnant

Elevated risk of miscarriage, preterm birth, neonatal health complications and possible longer term neurobehavioral abnormalities, including autism, suggest that a class of antidepressants known as selective serotonin reuptake inhibitors (SSRI) should only be prescribed with great caution and with full counseling for women experiencing depression and attempting to get pregnant, say researchers at Beth Israel Deaconess Medical Center, Tufts Medical Center and MetroWest Medical Center.

31 Oct 2012

SSRIs should be prescribed with great caution to those attempting to get pregnant

31 Oct 2012

Doxepin oral rinse relieves mouth pain from head and neck cancer treatment

30 Oct 2012

Antidepressant doxepin eases pain associated with oral mucositis

An oral rinse of the antidepressant doxepin significantly eased pain associated with oral mucositis in patients receiving radiation therapy for cancers of the head and neck, a study led by Mayo Clinic found. The findings were presented at the American Society for Radiation Oncology annual meeting in Boston.

29 Oct 2012

Hot flashes and night sweats can return after SSRI treatment in women

Hot flashes and night sweats can return after women stop using escitalopram-an antidepressant-to treat these menopause symptoms, according to a study published online this month in Menopause, the journal of the North American Menopause Society.

25 Oct 2012

Possible overlap exists between inflammatory bowel disease and IBS

Research unveiled today at the American College of Gastroenterology's (ACG) 77th Annual Scientific meeting in Las Vegas suggests a possible overlap of symptoms of two prevalent GI disorders: irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) and further suggests a possible link between subtle GI tract inflammation and IBS symptoms-a link that is also the focus of the first systemic review of the literature on this topic and an editorial both published in this month's American Journal of Gastroenterology.

23 Oct 2012

Antidepressant News and Research

Further Reading

LED light instantly triggers or reverses depression-like behavior in rodents

AZD6765 briefly improves treatment-resistant patients' depression symptoms in minutes

Takeda, Lundbeck announce FDA acceptance of vortioxetine NDA submission

Novel antidepressant targets brain receptors responsible for learning and memory

CBT may help reduce depression in people who have not responded to antidepressants

Naurex reports positive results from GLYX-13 Phase IIa trial on depression

Antidepressants in normal dosage may positively impact mood and seizure frequency

Certain SSRI medications fail to achieve same selectivity for prevention of SUDEP

Suicide ‘a major concern’ in childhood psychosis

Subthreshold bipolarity common in major depressive disorder

Holiday healthy eating reminders from Greenwich Hospital

Sharp decline in ECT availability and use in the U.S. general hospitals

Gene variants involved in glutamatergic transmission appear to increase risk of depression

Controlling depression can improve health status and social functioning in patients with heart failure

SSRIs should be prescribed with great caution to those attempting to get pregnant

SSRIs should be prescribed with great caution to those attempting to get pregnant

Doxepin oral rinse relieves mouth pain from head and neck cancer treatment

Antidepressant doxepin eases pain associated with oral mucositis

Hot flashes and night sweats can return after SSRI treatment in women

Possible overlap exists between inflammatory bowel disease and IBS

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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