Apoptosis News and Research

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Apoptosis is programmed cell death, the body's normal method of disposing of damaged, unwanted, or unneeded cells.

Potential breakthrough in cancer immunotherapy with gasdermin E

A new study published in the journal Nature in March 2020 reports the discovery of a new approach to cancer immunotherapy, which could be useful in many more cancers than at present.

11 Mar 2020

Exploring the biological link between reactivated HSV and neurological disease

Without even knowing it, most of us carry around latent Herpes Simplex Virus in our nervous system- a simple result of being born and living together with others carrying the virus.

10 Mar 2020

Effects of obesity mirror those of aging, study shows

Globally, an estimated 1.9 billion adults and 380 million children are overweight or obese. According to the World Health Organization, more people are dying from being overweight than underweight. Researchers at Concordia are urging health authorities to rethink their approach to obesity.

25 Feb 2020

New study expands the knowledge on tumor-suppressor role of HERC proteins

The RAF protein could be a therapeutical target to treat the tumor growth in regulated pathways by the p38 protein, according to a new study published in the journal Scientific Reports by a team of experts of the Faculty of Medicine and Health Sciences of the University of Barcelona and the Bellvitge Institute for Biomedical Research.

20 Feb 2020

Statins could reduce ovarian cancer risk, study suggests

A genetic study has found evidence to suggest that women who take statins in the long term could be less likely to develop ovarian cancer, according to new research funded by Cancer Research UK published today (Tuesday 18 February).

18 Feb 2020

Targeting regulatory T cells could boost the effects of cancer immunotherapy

A Ludwig Cancer Research study has identified a mechanism by which regulatory T cells, which suppress immune responses, adapt their metabolism to thrive in the harsh microenvironment of the tumor.

17 Feb 2020

Researchers identify key modifier in large genetic deletion linked to neurodevelopmental disorders

Neurodevelopmental disorders, including schizophrenia and autism, likely result from complex interactions that modify the effects of individual genes.

16 Feb 2020

Scientists create world’s first model of pituitary disease using human iPS cells

Researchers at Kobe University's Graduate School of Medicine have developed the world's first congenital pituitary hypoplasia model using patient-derived iPS cells.

14 Feb 2020

Study identifies two possible targets to halt liver damage in NASH

As much as 12 percent of adults in the United States are living with nonalcoholic steatohepatitis (NASH), an aggressive condition that can lead to cirrhosis or liver cancer.

6 Feb 2020

Making it all work: brain-dependent immune activation in embryos

How does the immune system develop its functionality? This has been an ongoing area of research for biologists. Now, a new study published in the journal NPJ Regenerative Medicine in February 2020 shows that in very early fetal life the brain must signal directions to the developing immune system to help it defend the body from infectious agents. This signaling markedly improves the capability of the embryo to survive when faced with bacterial infection.

4 Feb 2020

WPI researcher awarded grant for research into leading cause of aortic valve dysfunction

Worcester Polytechnic Institute researcher Kristen Billiar has been awarded a $154,000 grant from the American Heart Association to determine how cell death leads to calcium deposits in heart tissue that cause aortic valves to fail.

30 Jan 2020

Turning stink into therapy for atherosclerosis

In an amusing but amazing turnaround, it seems the most foul-smelling compound on earth, called putrescine, could help relieve chronic inflammation, most importantly in the arterial thickening called atherosclerosis. This discovery is reported in the journal Cell Metabolism in January 2020.

30 Jan 2020

Nanoparticle Trojan horse approach to clearing atherosclerotic plaques

Researchers from Michigan State University and Stanford University have designed special nanoparticles which could break down an atherosclerotic plaque from within. This could prevent heart attacks say researchers. The study titled, “Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis,” was published in the latest issue of the journal Nature Nanotechnology.

29 Jan 2020

New way to treat stroke using an already FDA-approved drug shows promise

Stroke is the third leading cause of death and disability in the United States. More than 87 percent are ischemic strokes, caused by obstruction of one or more cerebral arteries. With limited progress in developing treatments, there is a critical need for neuroprotective agents to effectively treat stroke.

29 Jan 2020

Iron overload, variant gene and malaria resistance linked in African study

A new study shows that a rare genetic mutation giving rise to a variant of the TP53 gene called P47S causes several linked biological processes.

24 Jan 2020

Long-term air pollution makes rhinitis symptoms worse

A new study published in the Journal of Allergy and Clinical Immunology reports that people exposed to polluted air out of doors show more severe symptoms of rhinitis, a very common condition also called a cold. This is due to an inflammation of the nasal mucosa.

23 Jan 2020

UCR receives $2.2 million grant to target critical oncogenes of B-cell lymphoma 2

One way to tackle cancer, the second-leading cause of death in the United States, is to target oncogenes -- genes that have the potential to cause cancer.

17 Jan 2020

Study sets the record straight on unproven therapy to treat sepsis

The Jan. 17 issue of the Journal of the American Medical Association features an important study about sepsis with an accompanying editorial by a University of Nebraska Medical Center expert.

17 Jan 2020

Scientists discover how B-cells in tumor cells promote a favorable immunotherapy response

The white blood cells are potent fighters that protect the body against foreign invaders, including pathogens and cancer cells. Scientists have found that the presence of B cells, which are powerhouses, in tumor cells, combat the disease from within.

16 Jan 2020

Researchers identify how marijuana accelerates growth of HPV-related head and neck cancer

University of California San Diego School of Medicine researchers have identified the molecular mechanism activated by the presence of tetrahydrocannabinol (THC) - the ingredient that causes people to feel the euphoria or "high" associated with cannabis - in the bloodstream that accelerates cancer growth in patients with human papillomavirus (HPV)-positive head and neck squamous cell carcinoma.

13 Jan 2020