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Lung cancer patients can be screened for ALK-inhibitor suitability

Anaplastic lymphoma kinase gene status in patients with lung adenocarcinoma can be determined non-invasively using circulating tumor cells, research shows.

8 Aug 2012

Folate, excision biomarkers not predictive for small-cell lung cancer response

Biomarkers associated with the folate metabolism and excision repair pathways are not sufficiently prognostic to aid chemotherapy decisions for patients with extensive-stage disease small-cell lung cancer, results of a phase III trial show.

8 Aug 2012

Interface zone fibroblasts play key role in gastric cancer

Interface zone fibroblasts in gastric adenocarcinoma promote the invasion, migration, and proliferation of cancer cells, as well as prevent apoptosis, to a greater degree than normal or tumor zone fibroblasts, say researchers.

8 Aug 2012

Prostate cancer cells can be killed by theranostic imaging without harming healthy cells

Experimenting with human prostate cancer cells and mice, cancer imaging experts at Johns Hopkins say they have developed a method for finding and killing malignant cells while sparing healthy ones.

8 Aug 2012

Stroma plays an important role in regulating spread of cancer cells

A major breakthrough by scientists at Queen's University Belfast could lead to more effective treatments for throat and cervical cancer.

8 Aug 2012

Tips to avoid and cope with kidney stones

Summer can mean more than just an increase in temperatures, humidity and outdoor physical activity. It can also mean an increased risk of kidney stones, which affect approximately 3.8 million people in the United States and are on the rise.

8 Aug 2012

Elimination diet may help manage cow's milk protein allergy in infants

Cow's milk protein allergy (CMPA), although difficult to diagnose in young children, shows a causative relationship to otolaryngic symptoms. A new study in the August journal, Otolaryngology-Head and Neck Surgery suggests an elimination diet may help manage such conditions in children under two and reduce the need for more serious upper airway tests and interventions.

8 Aug 2012

New class of drugs reduces adverse effects of cellular damage from cancer chemotherapy

Chemotherapy kills tumor cells, but it also wreaks havoc on the rest of the body. A team of researchers led by Igor Roninson of the South Carolina College of Pharmacy just reported the discovery of a new class of drugs that reduces the adverse effects of cellular damage from chemotherapy.

8 Aug 2012

TXNIP protein provides best available target for therapies against diabetes, Wolfram syndrome

Inflammation and cell stress play important roles in the death of insulin-secreting cells and are major factors in diabetes. Cell stress also plays a role in Wolfram syndrome, a rare, genetic disorder that afflicts children with many symptoms, including juvenile-onset diabetes.

8 Aug 2012

Study signals biomarker hope for monitoring COPD

The biomarkers desmosines and C-reactive protein could be used to assess disease severity in chronic obstructive pulmonary disease, show the results of a Swedish study.

7 Aug 2012

Applied BioCode receives U.S. patent for ‘Light Transmitted Assay Beads’

Applied BioCode, Inc. today announced that the United Stated Patent and Trademark Office has granted US Patent #8,232,092 "Light Transmitted Assay Beads," describing the method of decoding barcodes and analyzing bioassays using Barcoded Magnetic Beads (BMB) multiplex products.

7 Aug 2012

Astrocytes help reduce damaging effects of epilepsy

Epileptic fits are like thunderstorms raging in the brain: Nerve cells excite each other in an uncontrolled way so that strong, rhythmic electrical discharges sweep over whole brain regions. In the wake of such a seizure, the nerve cells are severely affected, and permanent damage is possible. The glia, a class of cells that surround the neurons in the brain, was long suspected to contribute to the damaging effects of epilepsy.

7 Aug 2012

Scientists discover biological marker that may help identify patients’ response to antidepressants

Scientists have discovered a biological marker that may help to identify which depressed patients will respond to an experimental, rapid-acting antidepressant. The brain signal, detectable by noninvasive imaging, also holds clues to the agent's underlying mechanism, which are vital for drug development, say National Institutes of Health researchers.

7 Aug 2012

Clinical trial targets breast cancer cells by injecting trastuzumab directly into the spinal fluid

In two to five percent of women with breast cancer, tumor cells migrate into the spinal fluid invading the tissue surrounding the brain and spinal cord called the meninges. While a rare complication, the condition is challenging because there is no agreed-upon standard of treatment, leaving little hope for patients affected. Northwestern Medicine- researchers are currently examining a novel approach to delivering an FDA approved drug that they hope will advance research for this type of cancer and lead to discoveries that may improve outcomes in the future.

7 Aug 2012

Blood levels of IL-6 protein may also serve as red flag for relapse in schizophrenia patients

Blood levels of a protein that helps regulate inflammation may also serve as a red flag for relapse in some schizophrenia patients, researchers said.

7 Aug 2012

Researchers identify myostatin as potential therapeutic target for muscular disorders

The study of muscular system protein myostatin has been of great interest to researchers as a potential therapeutic target for people with muscular disorders. Although much is known about how myostatin affects muscle growth, there has been disagreement about what types of muscle cells it acts upon. New research from a team including Carnegie's Chen-Ming Fan and Christoph Lepper narrows down the field to one likely type of cell.

7 Aug 2012

Study investigates role of inflammation in ALS mouse model

Amyotrophic lateral sclerosis (ALS) is a progressive disease wherein the cells of the central nervous system (CNS) involved in movement and coordination are destroyed. Although the mechanism of ALS is not completely understood, inflammation is believed to play a role in the disease process. A recent study by Howard Weiner and colleagues at Harvard Medical School and Tufts School of Medicine investigated the role of inflammation in a mouse model of ALS.

7 Aug 2012

Studies in mice reveal how mood-altering drugs may affect brain stem cells

Working with mice, Johns Hopkins researchers say they have figured out how stem cells found in a part of the brain responsible for learning, memory and mood regulation decide to remain dormant or create new brain cells. Apparently, the stem cells "listen in" on the chemical communication among nearby neurons to get an idea about what is stressing the system and when they need to act.

7 Aug 2012

Mutations in Ras gene alone may not cause tumours

Despite a huge amount of research effort, the molecular mechanisms that underlie the transition from a "normal" cell to a cancerous cell are only poorly understood. After the discovery of the first cancer-causing genes or oncogenes and the finding that they are mutated forms of normal cellular genes, it was widely believed that a single mutation was enough to cause cancer.

6 Aug 2012

Previously uncharacterized protein dramatically influences inflammation

A UNC-led team of scientists describes the function of a previously uncharacterized protein that dramatically influences inflammation.

6 Aug 2012

G Protein News and Research

Lung cancer patients can be screened for ALK-inhibitor suitability

Folate, excision biomarkers not predictive for small-cell lung cancer response

Interface zone fibroblasts play key role in gastric cancer

Prostate cancer cells can be killed by theranostic imaging without harming healthy cells

Stroma plays an important role in regulating spread of cancer cells

Tips to avoid and cope with kidney stones

Elimination diet may help manage cow's milk protein allergy in infants

New class of drugs reduces adverse effects of cellular damage from cancer chemotherapy

TXNIP protein provides best available target for therapies against diabetes, Wolfram syndrome

Study signals biomarker hope for monitoring COPD

Applied BioCode receives U.S. patent for ‘Light Transmitted Assay Beads’

Astrocytes help reduce damaging effects of epilepsy

Scientists discover biological marker that may help identify patients’ response to antidepressants

Clinical trial targets breast cancer cells by injecting trastuzumab directly into the spinal fluid

Blood levels of IL-6 protein may also serve as red flag for relapse in schizophrenia patients

Researchers identify myostatin as potential therapeutic target for muscular disorders

Study investigates role of inflammation in ALS mouse model

Studies in mice reveal how mood-altering drugs may affect brain stem cells

Mutations in Ras gene alone may not cause tumours

Previously uncharacterized protein dramatically influences inflammation

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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