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Probiotic offers protection against intestinal damage

There is a critical unmet need to help tighten and maintain a healthy intestinal barrier and treat a leaky gut. Researchers have now found that a unique strain of probiotic bacteria, Bifidobacterium bifidum BB1, enhances intestinal barrier function and protects against penetration of bacteria and various harmful agents in the intestine. The findings, detailed in an article in The American Journal of Pathology, published by Elsevier, can help advance the development of novel, targeted, naturally occurring probiotic therapy for patients with inflammatory bowel disease (IBD) and other inflammatory diseases, such as fatty liver disease or alcoholic liver disease, that are associated with a leaky or disordered intestinal barrier.

23 Aug 2024

Immune cells' two-pronged approach to maintaining acetyl-CoA reserves

Immune cells use two different routes to produce acetyl-CoA, an essential metabolite required to fight infection and cancer, reports a study led by Van Andel Institute scientists.

23 Aug 2024

Experts release revised lung cancer testing guidelines

The College of American Pathologists (CAP), the International Association for the Study of Lung Cancer (IASLC), and the Association for Molecular Pathology (AMP) announced today the open comment period for the revised 2018 evidence-based guideline, "Updated Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment With Targeted Tyrosine Kinase Inhibitors."

23 Aug 2024

Virginia Tech leads national initiative to predict and prevent future pandemics

Viruses like SARS-CoV-2 don't respect boundaries, moving between species and continents and leaving destruction as they go. Beating the next pathogen with pandemic potential means getting good at crossing borders ourselves - between fields of study, between research universities, and between scientists and the wider community.

23 Aug 2024

ChatGPT shown to save time in responding to patient inquiries

The groundbreaking ChatGPT chatbot shows potential as a time-saving tool for responding to patient questions sent to the urologist's office, suggests a study in the September issue of Urology Practice, an Official Journal of the American Urological Association. The journal is published in the Lippincott portfolio by Wolters Kluwer.

22 Aug 2024

$1.35 million grant to enhance safety and wellbeing in long-term care facilities

Researchers from the University of Colorado College of Nursing and CU School of Medicine on the Anschutz Medical Campus were awarded a $1.35 million grant from the Agency for Healthcare Research and Quality (AHRQ) to design and implement technologies that improve resident safety and employee wellbeing at long-term care facilities.

22 Aug 2024

Kynurenine pathway blockade shows promise for restoring brain metabolism in Alzheimer's

Among the many ways neuroscientists think Alzheimer's disease may strip away brain function is by disrupting the glucose metabolism needed to fuel the healthy brain.

22 Aug 2024

New $400 million donation reinforces Columbia's leadership in biomedical science

Columbia University announced today a new $400 million gift from Roy and Diana Vagelos, which will secure Columbia's leadership in biomedical science research and education and produce a vast array of compelling opportunities for improving society's health and wellbeing.

22 Aug 2024

Declining senses linked to worse mental health in older adults

Most people - up to 94% of U.S. adults - experience at least some dulling of their senses with age, finding themselves squinting at screens, craving stronger flavors, and missing snatches of conversations more and more frequently.

22 Aug 2024

Anti-obesity medication may help to prevent heart attacks and other major cardiac events

The anti-obesity medication semaglutide may help to prevent heart attacks and other major adverse cardiac events among overweight people who have cardiovascular disease, whether or not they also have heart failure, according to a new study led by UCL's Professor John Deanfield.

22 Aug 2024

$5 million grant to address combat wound infections in Ukraine

Faculty members in the Department of Emergency Medicine at the University of Colorado School of Medicine have been awarded $5 million by the U.S. Department of Defense to work with partners in Ukraine on clinical and logistical challenges associated with modern large-scale combat operations and prolonged casualty care.

22 Aug 2024

New NSF center to tackle pandemic expansion challenges

Professor of Ecology and Evolutionary Biology Nina Fefferman became a mathematician because she loves puzzles.

22 Aug 2024

New insights into macrophages' role in MASH and liver fibrosis

Formerly known as nonalcoholic steatohepatitis, metabolic dysfunction-associated steatohepatitis (MASH) is an inflammatory disease characterized by liver scarring or fibrosis that progressively impairs liver function.

22 Aug 2024

Cancer drug holds promise as a new treatment for neurodegenerative diseases

A type of drug developed for treating cancer holds promise as a new treatment for neurodegenerative diseases such as Alzheimer's, according to a recent study by researchers at Penn State, Stanford University and an international team of collaborators.

22 Aug 2024

Investigational drug reduces hot flashes associated with menopause

The investigational drug elinzanetant significantly reduces the frequency and severity of hot flashes associated with menopause while improving women's quality of life, new UVA Health research published in the prestigious Journal of the American Medical Association shows.

22 Aug 2024

Novel drug-carrying molecule slips past the lung's natural defenses to cure disease

A drug-carrying molecule designed to cure disease by slipping past the lung's natural defenses offers new hope for people with chronic or deadly respiratory diseases, say its creators, researchers in assistant professor Liheng Cai's Soft Biomatter Lab at the University of Virginia School of Engineering and Applied Science.

22 Aug 2024

Study shows frequent mitochondrial DNA insertion in the brain cells

As direct descendants of ancient bacteria, mitochondria have always been a little alien.

22 Aug 2024

New technique speeds up screening of DNA molecules

Studying how single DNA molecules behave helps us to better understand genetic disorders and design better drugs.

22 Aug 2024

Study reveals RAD51D variant enrichment in Chinese ovarian cancer patients

Researchers from BGI Genomics and Fudan University published new findings on OV among Chinese patients in JCO Global Oncology.

22 Aug 2024

MCG researchers investigate spaceflight-induced vision changes in astronauts

Physicians at the Medical College of Georgia at Augusta University are working with Polaris Dawn, the first of the Polaris Program's three human spaceflight missions, to better understand the eye changes many astronauts experience during spaceflight that can leave them with a wide range of symptoms once they return to Earth - from a new need for glasses to significant loss of vision.

22 Aug 2024