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Neurocrine Biosciences starts elagolix Phase IIb clinical trial for treatment of uterine fibroids

Neurocrine Biosciences, Inc. today announced that a Phase IIb clinical trial to evaluate elagolix for the treatment of uterine fibroids has been initiated.

27 Mar 2013

New model helps identify patients who are at high risk for hospital readmission

Hospital readmissions are a costly problem for patients and for the United States health care system with studies showing nearly 20 percent of Medicare patients are readmitted to the hospital within 30 days of discharge at an annual cost of $17 billion.

26 Mar 2013

Two studies shed light on molecular biology of three blood disorders

Two studies led by investigators at Weill Cornell Medical College shed light on the molecular biology of three blood disorders, leading to novel strategies to treat these diseases.

26 Mar 2013

WUSTL's Wang receives NSF grant to study oxygen consumption rates of individual cells

When scientists study cells, they need to know how much oxygen each cell consumes to determine its metabolism. However, existing technology limits this study to groups of cells, not individual cells. Lihong Wang, PhD, plans to change that.

21 Mar 2013

Study investigates prognostic indicators for BCa patients treated with RC

A new study from Japan investigated various prognostic indicators, including clinico-pathological and pre-operative hematological factors to develop a novel prognostic factors-based risk stratification model for disease-specific survival in bladder cancer patients treated with radical cystectomy.

19 Mar 2013

Trial evaluates ranolazine in patients with diabetes, coronary artery disease and angina

A commonly used anti-anginal drug reduces chest pain in patients with type 2 diabetes and appears to have a more pronounced effect in those with poorer glucose control, according to research presented today at the American College of Cardiology's 62nd Annual Scientific Session.

13 Mar 2013

Transfusion of older blood adversely affects patients undergoing cardiac surgery or critical care

Transfusion of donated blood more than three weeks old results in impaired blood vessel function, a new study of hospital patients shows.

11 Mar 2013

Genetic mutation that alters PIEZO1 ion channel in RBCs contributes to familial xerocytosis

A genetic mutation that alters the kinetics of an ion channel in red blood cells has been identified as the cause behind a hereditary anemia, according to a paper published this month in the Proceedings of the National Academy of Sciences by University at Buffalo scientists and colleagues.

11 Mar 2013

Aarbepoetin alfa does not improve anemic heart failure patients' health

Researchers from Cleveland Clinic and Sweden-based Sahlgrenska University Hospital have found that a commonly used drug to treat anemia in heart failure patients -darbepoetin alfa - does not improve patients' health, nor does it reduce their risk of death from heart failure.

11 Mar 2013

IV iron dextran alternative to oral iron for anemia in nondialysis CKD

Treatment with intravenous low-molecular-weight iron dextran seems to be an effective alternative for patients with nondialysis chronic kidney disease who remain anemic despite receiving oral iron and erythropoiesis-stimulating agents.

8 Mar 2013

Acceleron commences ACE-536 phase 2 study in beta-thalassemia

Acceleron Pharma, Inc., a biopharmaceutical company developing protein therapeutics for cancer and orphan diseases, today announced the initiation of a phase 2 study of its novel, investigational protein therapeutic, ACE-536, to treat patients with beta-thalassemia, a genetic hematologic disorder causing chronic and life-threatening anemia and serious complications affecting the spleen, liver and heart.

7 Mar 2013

FDA accepts AMAG’s Feraheme sNDA for review

AMAG Pharmaceuticals, Inc. today announced that the United States Food and Drug Administration (FDA) has accepted for review the company's supplemental new drug application (sNDA) for Feraheme (ferumoxytol) Injection for Intravenous (IV) use, which was submitted to the FDA in December 2012.

6 Mar 2013

Zinc protoporphyrin a marker for iron deficiency in low-income children

Researchers say that zinc protoporphyrin could be a useful measure for screening infants from low-income families for iron deficiency, as well as for monitoring response to therapy, especially among children with anemia.

6 Mar 2013

Androgen deprivation therapy interferes with diabetes control

Androgen deprivation therapy for prostate cancer hampers glycemic control in men with diabetes, report researchers.

5 Mar 2013

Mercury exposure raises diabetes risk later in life

People with a high level of mercury exposure in young adulthood are at an increased risk for developing diabetes later in life, report researchers.

1 Mar 2013

Community health team improves diabetes control in Polynesian community

A team of community health workers has been able to improve control of Type 2 diabetes in a group of individuals from American Samoa – a medically underserved territory with a high prevalence of obesity, diabetes, and other cardiovascular risk factors, report researchers.

25 Feb 2013

Quest Diagnostics signs definitive agreement to sell HemoCue business for $300 million

Quest Diagnostics, the world's leading provider of diagnostic information services, today announced that it has signed a definitive agreement to sell its HemoCue diagnostic products business to Radiometer Medical ApS for a purchase price of approximately $300 million plus customary adjustments for cash balances.

From Quest Diagnostics 25 Feb 2013

Dabigatran decreases risk of recurrent venous thromboembolism

New findings from two double-blind, randomized trials, RE-MEDY and RE-SONATE, show that dabigatran 150 mg twice daily reduces the risk of recurrent venous thromboembolism (VTE).

21 Feb 2013

Tranylcypromine may also hold promise in treating sickle cell disease

An antidepressant drug used since the 1960s may also hold promise for treating sickle cell disease, according to a surprising new finding made in mice and human red blood cells by a team from the University of Michigan Medical School.

19 Feb 2013

New study reveals how control of brain blood flow develops with age

A new study by Columbia Engineering researchers finds that the infant brain does not control its blood flow in the same way as the adult brain. The paper, which the scientists say could change the way researchers study brain development in infants and children, is published in the February 18 Early Online edition of Proceedings of the National Academy of Sciences (PNAS).

19 Feb 2013