Insulin News and Research

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Insulin is a hormone that is needed to convert glucose, starches and other food into energy needed for daily life. Insulin allows cells to use glucose for fuel and is secreted by beta cells in the islets of Langerhans. The release of insulin from the pancreas is stimulated by increased blood glucose, vagal nerve stimulation, and other factors. Insulin is obtained from various animals and available in a variety of preparations. Commercial insulin preparations differ in a number of ways, including differences in the animal species from which they are obtained; their purity, concentration, and solubility; and the time of onset and duration of their biologic action. An oral hypoglycemic agent is not a form of insulin therapy.

Hypothalamic ECM remodeling drives insulin resistance, contributing to obesity and diabetes

Researchers have discovered that remodeling of extracellular matrix (ECM) in the hypothalamus, specifically around AgRP neurons, drives insulin resistance and metabolic disease. Disrupting this ECM buildup improves insulin sensitivity and may be a promising treatment for obesity and diabetes.

19 Sep 2024

Cellular sludge around hunger neurons linked to worsening diabetes and obesity

Investigating ECM changes in the hypothalamus reveals mechanisms behind insulin resistance, offering insights into obesity and metabolic disease treatment.

19 Sep 2024

Phase 1 trial shows safety and efficacy of personalized vaccine for lymphoplasmacytic lymphoma

A team of researchers from City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the U.S., and The University of Texas M.D. Anderson Cancer Center, have reported safety and efficacy results from a Phase 1 trial that featured a personalized vaccine to treat lymphoplasmacytic lymphoma, a rare and slow-growing type of blood cancer, according to a study published recently in Nature Communications.

19 Sep 2024

IBD increases type 1 diabetes risk, revealing a bidirectional link between the two conditions

Researchers discovered that IBD significantly increases the risk of developing T1D, and this association works both ways, independent of genetics and familial factors. The strongest link was seen in ulcerative colitis patients.

19 Sep 2024

Large-scale study to explore impact of type 1 diabetes on brain development in children

About half of adults with type 1 diabetes face significant cognitive impairment, including problems with working memory and executive function that affect day-to-day thinking. But less is known about how the condition affects children during a window of time known to be critical for healthy brain development.

17 Sep 2024

Activation of PPARβ/δ-AMPK pathway shown to slow liver fibrosis development

A study led by Manuel Vázquez Carrera, group leader at the Diabetes and Associated Metabolic Diseases Networking Biomedical Research Centre (CIBERDEM) at the University of Barcelona, reveals advances in the understanding and treatment of liver fibrosis, a serious complication in the context of metabolic fatty liver disease, also known as MASLD (metabolic dysfunction-associated steatotic liver disease).

17 Sep 2024

Intensive diabetes treatment improves periodontal health

While the link between diabetes and periodontal disease is known, the impact of diabetes treatment on periodontal health is less well understood.

17 Sep 2024

SARS-CoV-2 exposure stabilizes BMI in infected adults while others see shifts

Real-world study reveals how SARS-CoV-2 infection influences body mass index, showing stable BMI in infected individuals while unexposed and pre-pandemic groups saw changes.

16 Sep 2024

Hormone therapy found to improve insulin sensitivity in menopausal women

Menopausal women are at greater risk of insulin resistance as a result of declining estrogen levels. Previous studies evaluating the potential benefits of hormone therapy on insulin resistance have produced mixed results.

16 Sep 2024

Unhealthy maternal diet may lead to heart and diabetes risks in offspring

Babies born to pregnant women with obesity are more likely to develop heart problems and diabetes as adults due to fetal damage caused by the high-fat, high-energy diet of their mother.

16 Sep 2024

Ketogenic diet restores menstrual cycles and boosts fertility in women with PCOS

A ketogenic diet restored menstrual cycles in all women with PCOS in a study, with over half of those desiring pregnancy achieving it. The diet could be a promising approach to enhance fertility.

15 Sep 2024

Study reveals how SARS-CoV-2 triggers diabetes by destroying pancreatic cells

Researchers from Weill Cornell Medicine have used a cutting-edge model system to uncover the mechanism by which SARS-CoV-2, the virus that causes COVID-19, induces new cases of diabetes, and worsens complications in people who already have it.

13 Sep 2024

Semaglutide and tirzepatide significantly improve weight loss and glycemic control in type 1 diabetes

Semaglutide and tirzepatide treatment lead to significant weight loss and improve blood sugar control in individuals with type 1 diabetes (T1D) who are living with overweight or obesity, new research being presented at the annual meeting of the European Association for the Study of Diabetes (EASD) in Madrid, Spain (9-13 September) has found.

13 Sep 2024

PPARs and PROTACs: A new strategy in cancer therapeutics

The growing challenge in cancer therapy lies in overcoming tumor heterogeneity, drug resistance, and associated side effects.

13 Sep 2024

Assessing the environmental impact of biotechnological pesticides

Biotechnological pesticides are a promising alternative to traditional chemical pesticides. But we have limited knowledge of how toxic they are to other organisms in the environment beyond regulatory assessments.

13 Sep 2024

Advanced insulin pump technology improves diabetes management for marathon runners

A series of case reports to be presented at this year's Annual Meeting of The European Association for the Study of Diabetes (EASD), Madrid (9-13 Sept), describe how a technology giving insulin doses informed by an insulin pump algorithm helped three adults with type 1 diabetes better manage their blood sugars enabling them to lead more active lives, and even run marathons.

13 Sep 2024

Obesity medication liraglutide is safe and effective in children aged 6 to <12 years

Liraglutide treatment significantly lowers BMI in obese children aged 6 to <12, but gastrointestinal side effects prompt the need for additional studies.

13 Sep 2024

GLP-2 regulates appetite by influencing gut-brain communication and gastrointestinal motility

Researchers examine the role of GLP-2 in regulating food intake through its effects on gastrointestinal motility and satiety signals, offering insights into potential obesity treatments.

12 Sep 2024

Real-world evidence highlights safety profile of tirzepatide in managing type 2 diabetes

As more people with type 2 diabetes (T2D) are taking medications to help manage blood sugar levels and weight loss, concerns about whether these drugs are safe have emerged.

12 Sep 2024

Fear of hypoglycemia limits physical activity in adults with type 1 diabetes

Despite high use of continuous glucose monitoring and insulin pump therapy, fear of hypoglycemia (low blood sugar) remains a significant barrier to physical activity and exercise for adults with type 1 diabetes (T1D), according to new research to be presented at this year's Annual Meeting of The European Association for the Study of Diabetes (EASD), Madrid (9-13 Sept).

12 Sep 2024

Insulin News and Research

Further Reading

Hypothalamic ECM remodeling drives insulin resistance, contributing to obesity and diabetes

Cellular sludge around hunger neurons linked to worsening diabetes and obesity

Phase 1 trial shows safety and efficacy of personalized vaccine for lymphoplasmacytic lymphoma

IBD increases type 1 diabetes risk, revealing a bidirectional link between the two conditions

Large-scale study to explore impact of type 1 diabetes on brain development in children

Activation of PPARβ/δ-AMPK pathway shown to slow liver fibrosis development

Intensive diabetes treatment improves periodontal health

SARS-CoV-2 exposure stabilizes BMI in infected adults while others see shifts

Hormone therapy found to improve insulin sensitivity in menopausal women

Unhealthy maternal diet may lead to heart and diabetes risks in offspring

Ketogenic diet restores menstrual cycles and boosts fertility in women with PCOS

Study reveals how SARS-CoV-2 triggers diabetes by destroying pancreatic cells

Semaglutide and tirzepatide significantly improve weight loss and glycemic control in type 1 diabetes

PPARs and PROTACs: A new strategy in cancer therapeutics

Assessing the environmental impact of biotechnological pesticides

Advanced insulin pump technology improves diabetes management for marathon runners

Obesity medication liraglutide is safe and effective in children aged 6 to <12 years

GLP-2 regulates appetite by influencing gut-brain communication and gastrointestinal motility

Real-world evidence highlights safety profile of tirzepatide in managing type 2 diabetes

Fear of hypoglycemia limits physical activity in adults with type 1 diabetes

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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