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Work-related stress linked to increased risk of future sick leave in middle-aged women

Middle-aged women who experience work-related stress have a significantly increased risk of future sick leave, a University of Gothenburg study shows. Lack of influence and conflicts at work are clear stress factors.

15 Aug 2024

The FDA calls them ‘recalls,’ yet the targeted medical devices often remain in use

In 2016, medical device giant Abbott issued a recall for its MitraClip cardiac device — "a Class I recall, the most serious type," the FDA said.

15 Aug 2024

Artificial intelligence predicts tongue disease with 96 percent accuracy

A novel system that uses machine learning to predict tongue disease.

15 Aug 2024

New research gives unprecedented view of colorectal cancer genetic makeup

Researchers provided a comprehensive genomic characterization of colorectal carcinoma, a type of cancer that starts in the colon or rectum, through whole-genome sequencing of 2,023 samples, identifying novel driver genes, molecular subgroups, and potential clinical implications.

15 Aug 2024

Brain scans can detect consciousness in some unresponsive patients

New research co-led by experts at Mass General Brigham found that brain scans can detect consciousness in some patients with brain injury who are unresponsive.

14 Aug 2024

Engineering extracellular vesicles for potential treatment of type 1 diabetes

Within each of us lies an army of cells whose topmost duty is protecting against external pathogens and internal threats such as proliferating cancer cells.

14 Aug 2024

Very-low-calorie keto diet slashes fat and oxidative stress, boosting metabolic health in obesity

Study reveals that an 11-week, very-low-calorie ketogenic diet significantly reduces body fat and improves glucose metabolism in obese individuals, while also lowering oxidative stress markers, indicating better overall metabolic health.

14 Aug 2024

Midlife and early senior years marked by dramatic molecular shifts

If it's ever felt like everything in your body is breaking down at once, that might not be your imagination. A new Stanford Medicine study shows that many of our molecules and microorganisms dramatically rise or fall in number during our 40s and 60s.

14 Aug 2024

Breakthrough in understanding cell communication during inflammation

Indiana University School of Medicine researchers have made significant progress in understanding how cells communicate during inflammation.

14 Aug 2024

Study highlights mismatch in child injury data from crashes

Researchers from the Center for Injury Research and Prevention (CIRP) at Children's Hospital of Philadelphia (CHOP) found discrepancies between crash reports and hospital data that might paint an incomplete or inaccurate picture of how crashes impact the safety of child passengers.

14 Aug 2024

Understanding the complexities of epigenetic aging clocks in health research

A new editorial was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 14 on July 17, 2024, entitled, "Recalibrate concepts of epigenetic aging clocks in human health."

14 Aug 2024

Ketogenic diet can boost efficacy of pancreatic cancer therapy

A study of fasting and the ketogenic diet reveals a new vulnerability of pancreatic tumors to an existing cancer drug.

14 Aug 2024

Liver stiffness becomes crucial indicator for post-treatment hepatitis C risk assessment

Hepatitis C can be cured in almost all cases with modern medication. However, if advanced liver damage is already present at the time of cure, there is still a residual risk of liver cancer and complications of portal hypertension, such as abdominal fluid, bleeding from the digestive tract and confusion.

14 Aug 2024

Study finds no clinically useful biomarkers for long COVID in routine lab tests

Whether tests in current use were adequate to identify post-acute sequelae of SARS-CoV-2 (PASC).

14 Aug 2024

Over 47,000 heat-related deaths estimated to have occurred in Europe in 2023

Researchers projected age- and sex-specific heat-related deaths across Europe by 2023. They also calculated the death load saved via social adaptation to increasing temperatures since 2000.

14 Aug 2024

New targets for improved cancer immunotherapy

In the past two decades, immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, showing promising results against various solid tumors. This study reviews recent developments in ICIs, focusing on new targets like T cell immunoreceptors with Ig and ITIM domains (TIGIT), T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3), and lymphocyte activation gene-3 (LAG-3). These targets aim to overcome resistance mechanisms limiting the effectiveness of current therapies, such as anti-PD-1 and anti-CTLA-4. By identifying and developing these new ICIs, researchers hope to improve treatment outcomes and provide new therapeutic options for cancer patients.

14 Aug 2024