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CureVac begins phase I study to assess intratumoral application of RNAdjuvant technology in patients with solid tumors

CureVac AG, a fully-integrated biotechnology company pioneering mRNA-based drugs, today announced it has initiated a Phase I study assessing the intratumoral application of its novel RNAdjuvant technology in patients with superficial solid tumors that are easily accessible for repeated intratumoral injections. RNAdjuvant is designed to amplify the scope and quality of an immune response when used alone or in combination with other immune therapies.

28 Oct 2017

Chinese scientists establish synthesis of promising compound to fight against pancreatic cancer

Intriguing antitumor activity is found in a very promising class of natural compounds: cyclic depsipeptides, which have a challenging structure that makes their investigation difficult. Now, Chinese scientists have established the synthesis of a member compound, which is especially promising in killing pancreatic cancer stem cells.

28 Oct 2017

New findings offer promising druggable target to root out metastatic pancreatic cancer

Cancer of the pancreas is a deadly disease, with a median survival time of less than six months. Only one in 20 people with pancreatic cancer survives five years past the diagnosis. The reason is the cancer's insidiousness; tumor cells hide deep inside the body, betraying no symptoms until late in the disease, when the cancer has almost invariably spread to other organs.

28 Oct 2017

Clinical trial shows promising results for treatment of patients with recurrent high-grade glioma

New data from a Phase I clinical trial led by Clark Chen, M.D., Ph.D., Lyle French Chair in Neurosurgery and Head of the University of Minnesota Medical School Department of Neurosurgery shows more than a quarter of patients with recurrent high-grade glioma, a form of brain cancer, were alive more than three years after treatment.

28 Oct 2017

Genome-wide molecular tests can guide treatment in recurrent glioblastoma, study shows

Several patients with recurring glioblastoma, a deadly brain cancer, survived for more than a year in a clinical trial believed to be the first to use comprehensive DNA and RNA sequencing of a patient's tumor to inform treatment for these patients in real-time.

27 Oct 2017

Newly identified microRNA impedes malignancy of tumor cells and metastasis

Cancer cells can reactivate a cellular process that is an essential part of embryonic development. This allows them to leave the primary tumor, penetrate the surrounding tissue and form metastases in peripheral organs.

27 Oct 2017

‘Precision Medicine’ may not always be so precise when applied to diverse populations, study says

Precision Medicine in oncology, where genetic testing is used to determine the best drugs to treat cancer patients, is not always so precise when applied to some of the world's more diverse populations, according to a study led by the Translational Genomics Research Institute, an affiliate of City of Hope, and the Keck School of Medicine of the University of Southern California.

27 Oct 2017

Sleeper cells in cancerous tumors can be destroyed if they possess specific defects

In many metastasized types of cancer, disseminated tumors grow back despite successful chemotherapy. As a research team under the direction of the University of Bern, Switzerland, has now discovered, this is because of isolated cancer cells that survive the chemotherapy due to a phase of dormancy.

27 Oct 2017

Scientists define molecular mechanism that triggers pump-induced disease

Researchers at Texas Tech University Health Sciences Center investigated a pump-induced disease and defined the molecular mechanism that triggers it. The study, "On the effect of hyperaldosteronism-inducing mutations in Na/K pumps," was published in the October issue of the Journal of General Physiology.

26 Oct 2017

Updated guidelines offer support for appropriate, safe use of accelerated partial-breast irradiation

Cleveland Clinic researcher Chirag Shah, M.D., led the development of updated guidelines for the appropriate and safe utilization of accelerated partial-breast irradiation. The guidelines are published online in the journal, Brachytherapy.

26 Oct 2017

Pharmacist identifies protein linked to tumor growth in gallbladder cancer

Patients with gallbladder cancer often show few or no symptoms for long periods of time. As a result, the tumors are only detected at a late stage of the disease when treatment is often no longer possible.

25 Oct 2017

Researchers develop new way to genetically engineer T cells for treating leukemia relapse

Researchers at Fred Hutchinson Cancer Research Center and the University of Washington have developed a novel way to genetically engineer T cells that may be effective for treating and preventing leukemia relapse.

25 Oct 2017

Scientists develop new method for enhancing breast reconstruction with autologous fat

5.000 women develop breast cancer every year in Austria. Surgical removal of the tumour continues to be a crucial part of successful treatment but frequently results in loss of breast tissue, making partial mastectomy necessary in 80% of cases.

25 Oct 2017

Fight CRC and CRI announce publication of ‘A Blueprint to Advance Colorectal Cancer Immunotherapies’

Fight Colorectal Cancer and the Cancer Research Institute, are proud to announce "A Blueprint to Advance Colorectal Cancer Immunotherapies" will be published in the November 2017 issue of the journal Cancer Immunology Research (published online ahead of print on October 16, 2017).

24 Oct 2017

New genetic variants contribute to the risk of breast cancer in women, study reveals

A new study reveals seventy-two novel genetic variants that are responsible for breast cancer risk. Published in the journals Nature and Nature Genetics, of these 72 variants, 65 are common variants that predispose patients to breast cancer and a further seven variants predispose particularly to estrogen -receptor negative breast cancer - the subcategory of cases that do not respond to hormonal treatments.

24 Oct 2017

Genomic roots of ovarian tumors may arise in fallopian tubes, study suggests

Some scientists have suspected that the most common form of ovarian cancer may originate in the fallopian tubes, the thin fibrous tunnels that connect the ovaries to the uterus.

24 Oct 2017

'Intelligent' nanoparticles could help treat cancer patients

Scientists from the University of Surrey have developed 'intelligent' nanoparticles which heat up to a temperature high enough to kill cancerous cells - but which then self-regulate and lose heat before they get hot enough to harm healthy tissue.

24 Oct 2017

Rush uses SAVI SCOUT technology to enhance breast surgery for women

Women who need breast surgery to remove an abnormality that cannot be felt, also known as a non-palpable breast lesion, now may benefit from the convenience and comfort provided by an advanced new tissue locating technology offered at Rush University Medical Center.

24 Oct 2017

Study finds lung cancer driver ALK-fusion in mucosal melanoma

Melanomas caused by sun exposure have been matched with targeted treatments and immunotherapies, in many cases dramatically extending patients' lives. However, there are other kinds of melanoma not related to sun exposure and because they are caused by different genetic changes, they are not susceptible to the same targeted treatments.

23 Oct 2017

Brazilian scientists examine how benzopyrene can cause cancer

Benzo[a]pyrene is a potent carcinogen and mutagen present in cigarette smoke, automotive exhaust, burnt wood fumes, barbecued and smoked meat etc.

23 Oct 2017

Tumor News and Research

CureVac begins phase I study to assess intratumoral application of RNAdjuvant technology in patients with solid tumors

Chinese scientists establish synthesis of promising compound to fight against pancreatic cancer

New findings offer promising druggable target to root out metastatic pancreatic cancer

Clinical trial shows promising results for treatment of patients with recurrent high-grade glioma

Genome-wide molecular tests can guide treatment in recurrent glioblastoma, study shows

Newly identified microRNA impedes malignancy of tumor cells and metastasis

‘Precision Medicine’ may not always be so precise when applied to diverse populations, study says

Sleeper cells in cancerous tumors can be destroyed if they possess specific defects

Scientists define molecular mechanism that triggers pump-induced disease

Updated guidelines offer support for appropriate, safe use of accelerated partial-breast irradiation

Pharmacist identifies protein linked to tumor growth in gallbladder cancer

Researchers develop new way to genetically engineer T cells for treating leukemia relapse

Scientists develop new method for enhancing breast reconstruction with autologous fat

Fight CRC and CRI announce publication of ‘A Blueprint to Advance Colorectal Cancer Immunotherapies’

New genetic variants contribute to the risk of breast cancer in women, study reveals

Genomic roots of ovarian tumors may arise in fallopian tubes, study suggests

'Intelligent' nanoparticles could help treat cancer patients

Rush uses SAVI SCOUT technology to enhance breast surgery for women

Study finds lung cancer driver ALK-fusion in mucosal melanoma

Brazilian scientists examine how benzopyrene can cause cancer

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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