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New cell-based assay shown to rapidly profile drug resistance to three widely used SARS-CoV-2 main protease inhibiting drugs

In a recent study posted to the bioRxiv* pre-print server, researchers tested three next-generation severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) inhibitors, namely, nirmatrelvir, ensitrelvir, and FB2001, using a novel cell-based assay.

1 Mar 2023

Evidence that cross-reactive immunity from common human coronaviruses can influence response to SARS-CoV-2

In a recent study published in the journal Vaccines, researchers in Saudi Arabia and the United States examined immune responses and immunoglobulin G (IgG) cross-reactivity in individuals infected with Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

28 Feb 2023

CN Bio extends microphysiological system portfolio with PhysioMimix Single-Organ Higher Throughput System

CN Bio, a leading Organ-on-a-Chip (OOC) company that designs and manufactures single-and multi-organ microphysiological systems (MPS), today announced the commercial launch of the PhysioMimix™ Single-organ Higher Throughput (HT) System.

From CN Bio 28 Feb 2023

COVID-19 does not increase the risk of Streptococcus pneumoniae infection

SARS-CoV-2 infection does not appear to influence pneumococcal colonization in the upper respiratory tract.

28 Feb 2023

BICO introduces new life sciences manufacturing platform integrating ABB Robotics technology

BICO Group’s business area Bioautomation is expanding its manufacturing product offering by introducing The Nucleus™ Automation Ecosystem, a fully integrated platform bringing a new level of modularity, flexibility and scalability to the manufacturing market.

From SCIENION GmbH 27 Feb 2023

Innovative methodology to detect viral RNA

Experts from the University of Barcelona, the Institute for Advanced Chemistry of Catalonia, the Institute of Microelectronics of Barcelona and the Aragon Nanoscience and Materials Institute of Aragon —a joint institute of the CSIC and the University of Zaragoza— have developed a new method to detect RNA viruses based on the triplex-forming probe technology.

27 Feb 2023

High-dose ivermectin does not reduce COVID-19 symptom duration among mild-to-moderate outpatients

Researchers evaluate the efficacy of ivermectin in a maximum dosage of 600 μg/kg/day over six days in treating early mild-to-moderate COVID-19.

27 Feb 2023

Rapid AAV Titer for Bioprocessing in Gene Therapy

In this article, News-Medical talks to Sartorius about biosensing and bioprocessing in gene therapy, while also discussing the various products Sartorius produces in order to aid in this.

From Sartorius 27 Feb 2023

Oral fluid shows excellent potential for epidemiological surveillance of respiratory pathogens

Announcing a new article publication for Zoonoses journal. Oral fluid (OF) is a new safe, non-invasive, convenient, and efficient biological sample that can be used for virus nucleic acid and antibody detection.

24 Feb 2023

What nutritional role does carrot powder play in probiotic cheese?

In a recent study published in the Journal of Dairy Science, researchers evaluated carrot powder and its application in probiotic soft cheese.

24 Feb 2023

Apolipoprotein E4 promotes the development of Alzheimer’s disease

Researchers characterize the effects of neuronal apolipoprotein E4 on Alzheimer’s disease-associated pathology.

23 Feb 2023

Following third dose of BNT162b2, adverse events increased in those with prior COVID-19

Previous SARS-CoV-2 infection exacerbates the adverse reactions experienced after receipt of the third booster dose.

23 Feb 2023

Study shows antibody-dependent SARS-CoV-2 transmission and pathogenesis

Researchers reported that some monoclonal nAbs directed against distinct RBD epitopes nested inside the SARS-CoV-2 S could substitute ACE2 as a receptor and support fusion between viral and host cell membranes facilitating viral infectivity.

23 Feb 2023

A possible link between aggregation of SARS-CoV-2 proteins and protein misfolding diseases

A new study in the journal Nature Communications aimed to analyze the aggregation propensity in the proteins of both SARS-CoV-2 and SARS-CoV.

21 Feb 2023

Researchers provide a framework for unifying and categorizing neurodegenerative diseases based on eight hallmarks

Researchers presented eight hallmarks of neurodegenerative diseases (NDDs), their in vivo biomarkers, and interactions to help categorize NDDs and specify patients within a specific NDD.

21 Feb 2023

Propylene glycol prevents airborne transmission of respiratory viruses

Researchers assess the ability of propylene glycol to inactivate infection caused by respiratory viruses and prevent airborne transmission.

20 Feb 2023

Utilizing CRISPR to discover new therapy options for COPD

In this interview, we speak to Ceri Wiggins, a Director at AstraZeneca, about the many applications of CRISPR and its role in discovering new COPD therapies.

From Society for Laboratory Automation and Screening (SLAS) 20 Feb 2023

Prior COVID highly protective against severe disease ten months post-infection

In a recent study published in the Lancet, researchers performed a systematic review of scientific literature published from inception up to September 31, 2022, that documented the reduction in risk of coronavirus disease 2019 (COVID-19) among individuals with a prior severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection vis-à-vis those with no COVID-19 history.

19 Feb 2023

Research reports full efficacy of Sotrovimab against BQ.1.1 viral replication in a non-human primate challenge model

Researchers used a non-human primate model to show that Sotrovimab, a commercial mAb also known as Xevudy, was fully effective against SARS-CoV-2 Omicron BA.5 sub-lineage and its derivatives, such as BQ.1.1.

17 Feb 2023

The relationship between antibody titers and incident SARS-CoV-2 infection among recipients of a primary vaccine series

Researchers evaluated whether serologic testing could help estimate the risk of SARS-CoV-2 infection in vaccinated individuals who had not received a booster dose.

17 Feb 2023

Assay News and Research

New cell-based assay shown to rapidly profile drug resistance to three widely used SARS-CoV-2 main protease inhibiting drugs

Evidence that cross-reactive immunity from common human coronaviruses can influence response to SARS-CoV-2

CN Bio extends microphysiological system portfolio with PhysioMimix Single-Organ Higher Throughput System

COVID-19 does not increase the risk of Streptococcus pneumoniae infection

BICO introduces new life sciences manufacturing platform integrating ABB Robotics technology

Innovative methodology to detect viral RNA

High-dose ivermectin does not reduce COVID-19 symptom duration among mild-to-moderate outpatients

Rapid AAV Titer for Bioprocessing in Gene Therapy

Oral fluid shows excellent potential for epidemiological surveillance of respiratory pathogens

What nutritional role does carrot powder play in probiotic cheese?

Apolipoprotein E4 promotes the development of Alzheimer’s disease

Following third dose of BNT162b2, adverse events increased in those with prior COVID-19

Study shows antibody-dependent SARS-CoV-2 transmission and pathogenesis

A possible link between aggregation of SARS-CoV-2 proteins and protein misfolding diseases

Researchers provide a framework for unifying and categorizing neurodegenerative diseases based on eight hallmarks

Propylene glycol prevents airborne transmission of respiratory viruses

Utilizing CRISPR to discover new therapy options for COPD

Prior COVID highly protective against severe disease ten months post-infection

Research reports full efficacy of Sotrovimab against BQ.1.1 viral replication in a non-human primate challenge model

The relationship between antibody titers and incident SARS-CoV-2 infection among recipients of a primary vaccine series

eBook: Using iPSCs models for human disease research and drug discovery eBook

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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