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Review highlights TIGIT as a promising second-generation immunotherapy target

Malignant tumors remain a major threat to human health, with conventional therapies and first-generation immune checkpoint inhibitors (ICIs) facing limitations like drug resistance and low response rates.

5 Jun 2026

Scientists discover new intracellular immune defense against infections

When we think of the immune system, most people imagine white blood cells putting up a fight against invading germs within our bloodstream.

4 Jun 2026

Novel technology maps single-cell DNA-protein interactions

A new technology allows scientists to map, in single cells, the DNA binding sites of transcription factors and other regulatory proteins that control gene activity, according to a study led by investigators at Weill Cornell Medicine and the New York Genome Center.

4 Jun 2026

Early glucocorticoid tapering reduces damage in vasculitis maintenance therapy

Glucocorticoids are the cornerstone of initial vasculitis treatment, used to rapidly control inflammation and protect vital organs.

4 Jun 2026

Blood protein signature can predict lung cancer risk before diagnosis

Researchers at the Francis Crick Institute and University College London (UCL), funded by Cancer Research UK and the European Research Council (ERC), have identified a 14-protein signature in the blood that can predict lung cancer risk more than five years before diagnosis.

4 Jun 2026

Microglia transitions act as critical turning point in Alzheimer's

Researchers from VIB, KU Leuven, the UK-DRI and Muna Therapeutics, funded by, among others, ERC, have uncovered a critical biological transition that may determine whether Alzheimer's disease pathology leads to dementia.

4 Jun 2026

Study reveals how breast cancer cells hide in the bone marrow

Treating breast cancer remains a major medical challenge worldwide. This is largely due to the ability of breast cancer cells to remain hidden for years before triggering a relapse, which can occur even decades after successful treatment of the primary tumor.

4 Jun 2026

Repurposed cancer therapy enables successful kidney transplantation

A pioneering clinical trial has successfully enabled three patients with end-stage kidney disease to receive previously improbable kidney transplants.

4 Jun 2026

New topical gel uses repurposed MS drug to heal burns

Researchers at the Terasaki Institute for Biomedical Innovation and the University of Arizona College of Medicine have developed a topical gel formulation with 4-aminopyridine (4-AP), to treat burn wounds, achieving near-complete closure in 21 days.

4 Jun 2026

Diverse cancer subtypes can originate from a single progenitor cell

How do different cancer subtypes arise? Do they originate from distinct cells, or from a single multipotent cell capable of differentiating into multiple cell types?

4 Jun 2026

Vaping devices and flavors affect genes differently

Vaping exposure affects gene activity in the mouth, with variations linked to device type and flavor, suggesting unique molecular responses compared to smoking.

4 Jun 2026

Webinar - Modality agnostic drug discovery strategies for data sparse targets: Lessons learned from Avammune & Cresset, hosted by Visioneers

Are you working on data-sparse or novel targets? Join us June 11th to learn how Avammune progressed from early concepts to trial-stage candidates in this space.

From Cresset 4 Jun 2026

Researchers discover a biological barrier that limits mucosal vaccine immunity

A consistent biological barrier that stops the immune system from making the antibodies most needed to protect the nose and throat from respiratory viruses has been identified.

4 Jun 2026

New all-oral regimen improves treatment convenience for AML patients

The ASCERTAIN V clinical trial demonstrated that an all-oral drug combination for older patients with acute myeloid leukemia (AML) is an effective alternative to the current standard, which requires repeated hospital or office visits for intravenous treatment.

3 Jun 2026

Novel CAR T treatment makes previously impossible kidney transplants possible

A pioneering clinical trial has successfully enabled two patients with end-stage kidney disease to receive previously improbable kidney transplants.

3 Jun 2026

Light-activated proteins demonstrate quantum sensing and radio wave control

Until now, quantum sensing has primarily been known from solid-state materials such as diamonds with deliberately introduced tiny defects.

3 Jun 2026

Could GLP-1 drugs help prevent breast cancer? New study points to a possible link

A large retrospective cohort study of 111,646 overweight or obese women found that GLP-1 agonist exposure was associated with lower breast cancer incidence. After propensity-score matching, GLP-1 exposure was linked to nearly 30% lower odds of breast cancer, but the authors stress that randomized trials are needed before these drugs can be considered for prevention.

3 Jun 2026