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Transitioning pancreatic cells show lasting epigenetic cancer traits

Johns Hopkins Medicine scientists say they have found a pattern of so-called epigenetic "marks" in a transition state between normal and pancreatic cancer cells in mice, and that the normal cells may keep at least a temporary "memory" of those cancer-linked marks.

24 Apr 2025

Manipulating a master regulator prevents tumor growth in mice

A protein identified nearly 40 years ago for its ability to stimulate the production of red blood cells plays a surprising, critical role in dampening the immune system's response to cancer.

24 Apr 2025

Breakthrough DNA editing in Lactobacillus offers safer probiotics

A Kobe University team was able to edit the DNA of Lactobacillus strains directly without a template from other organisms.

24 Apr 2025

Chimeric RNA offers new clues for tailoring prostate cancer therapies

Prostate cancer has distinct genetic properties in different groups of men that can be targeted to improve patient outcomes, UVA Cancer Center researchers have discovered.

24 Apr 2025

Expansion of mutant blood cells linked to worse cancer outcomes

Researchers from the Francis Crick Institute, UCL, Gustave Roussy and Memorial Sloan Kettering Cancer Center (MSK), have discovered that expansion of mutant blood cells, a phenomenon linked to aging, can be found in cancerous tumors, and this is associated with worse outcomes for patients.

23 Apr 2025

Epigenetic flexibility helps embryos avoid developmental errors

An international research team led by Helmholtz Munich has, for the first time, provided a detailed insight into how the spatial organization of genetic material is established in the cell nucleus of early embryos within the first hours after fertilization.

23 Apr 2025

Research offers new hope in the fight against antibiotic-resistant bacteria

Antibiotic resistance is a serious threat to public health. When antibiotics don't work, we risk not being able to treat many types of infections and people who would previously have been cured, can die.

23 Apr 2025

Bacterial toxin may contribute to rise in early-onset colorectal cancer

In an effort to explain a modern medical mystery, an international team of researchers led by the University of California San Diego has identified a potential microbial culprit behind the alarming rise in early-onset colorectal cancer: a bacterial toxin called colibactin.

23 Apr 2025

Machine learning unlocks millions of safer CRISPR enzymes for gene editing

Genome editing has advanced at a rapid pace with promising results for treating genetic conditions-but there is always room for improvement.

22 Apr 2025

Obesity alters the rhythm of liver’s starvation response

Researchers led by Keigo Morita and Shinya Kuroda of the University of Tokyo have revealed a temporal disruption in the metabolism of obese mice when adapting to starvation despite no significant structural disruptions in the molecular network.

22 Apr 2025

New study sheds light on 3D gene hubs driving brain cancer

The way DNA folds inside the nucleus of brain cells may hold the key to understanding a devastating form of brain cancer called glioblastoma, suggests a new preclinical study from Weill Cornell Medicine researchers.

22 Apr 2025

Dr. Jeremie Poschmann's data-driven approach to immunology and translational science

In a wide-ranging Genomic Press Interview, Dr. Jeremie Poschmann of INSERM and Université de Nantes shares the story behind his bold, data-centric approach to immunology and translational science.

22 Apr 2025

Boost your transfection success with these proven expert tips

Gain expert insights in this interview on achieving transfection success. Explore proven strategies to optimize your approach and enhance results.

From Sartorius 22 Apr 2025

Fruit fly study reveals key brain proteins that help prevent seizures

One in ten people will have at least one seizure in their life, but effective treatments for seizures remain very limited, in part due to incomplete understanding of the brain mechanisms involved.

21 Apr 2025

Researchers uncover genetic link between autism spectrum disorder and myotonic dystrophy type 1

Scientists from The Hospital for Sick Children (SickKids) and University of Las Vegas Nevada (UNLV) have uncovered a genetic link between autism spectrum disorder (ASD) and a rare genetic condition called myotonic dystrophy type 1 (DM1).

21 Apr 2025

Exploring the impact of R-loops on genome integrity and disease

This new review article highlights the pivotal and paradoxical role of R-loops in maintaining genomic stability while simultaneously posing risks to it.

19 Apr 2025

Chromosomal rearrangements drive color evolution in stick insects

Understanding the material basis of adaptive evolution has been a central goal in biology dating back to at least the time of Darwin.

18 Apr 2025

Researchers identify gene targets that may protect against Alzheimer’s

A study published in the American Journal of Human Genetics by researchers at Baylor College of Medicine and the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children's Hospital provides solutions to the pressing need to identify factors that influence Alzheimer's disease (AD) risk or resistance while providing an avenue to explore potential biological markers and therapeutic targets.

17 Apr 2025

Researchers use algorithm to pinpoint disease risk mutations in noncoding DNA

Researchers from Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania (Penn Medicine) have successfully employed an algorithm to identify potential mutations which increase disease risk in the noncoding regions our DNA, which make up the vast majority of the human genome.

17 Apr 2025