Growth Factor News and Research

RSS

International study identifies new drug target for treating glioblastoma

A new international study co-led by Cleveland Clinic has identified a new drug target for treating glioblastoma. This target is part of a never-before defined cellular pathway found to contribute to the spread and proliferation of a dangerous subset of cancer cells, called glioma stem cells.

22 Aug 2019

Dacomitinib treatment for lung cancer increases overall survival but has more side effects

Since its approval in April 2019, dacomitinib has been available for the first-line treatment of adult patients with locally advanced or metastatic non-small cell lung cancer with epidermal growth factor receptor activating mutations.

20 Aug 2019

Lipid signaling pathway may enhance T cell-mediated immunotherapy

The immune system surveils our body looking for things that don't belong, often bacteria and viruses. While cancer cells are abnormal cells that undergo unregulated cell growth, they are good at evading detection by the immune system.

19 Aug 2019

Boosting a single brain molecule can change 'dispositional anxiety' in nonhuman primates

Boosting a single molecule in the brain can change "dispositional anxiety," the tendency to perceive many situations as threatening, in nonhuman primates, researchers from the University of California, Davis, and the University of Wisconsin-Madison have found.

16 Aug 2019

NUS scientists discover control mechanism that regulates traffic across blood vessels

NUS scientists have discovered a control mechanism that regulates the traffic of cells and substances across blood vessels. This effect can have significant impact on cancer metastasis.

13 Aug 2019

Treatment with both targeted cancer therapy and MS drug halts glioblastoma stem cells

Glioblastoma is an aggressive form of brain cancer that infiltrates surrounding brain tissue, making it extremely difficult to treat with surgery.

9 Aug 2019

CAR-T cells used to target glioblastoma

Immunotherapy is the new weapon against cancers and building upon existing research, a team of researchers from the Massachusetts General Hospital have devised a way to make immunotherapy more effective in a deadly and common form of brain cancer called glioblastoma.

24 Jul 2019

Fat cells may be egging on melanoma cells to become more aggressive

A new study has shown that fat cells could be implicated in the transformation of the melanoma cells in the skin into highly malignant cells that spread to the different organs of the body. A team from the Tel Aviv University, led by Prof. Carmit Levy and Dr. Tamar Golan of the Department of Human Genetics and Biochemistry at TAU's Sackler School of Medicine published their findings in the journal Science Signaling this week.

24 Jul 2019

Rare inherited enzyme disorder offers new clues about fibrotic conditions

What can a family of rare inherited disorders teach scientists about more common health problems like fibrosis? Plenty, based on research led by St. Jude Children's Research Hospital scientists that appears today in the journal Science Advances.

17 Jul 2019

Gene modulation goes wireless hacking the "boss gene"

Researchers from the University at Buffalo have successfully used technology to wirelessly tweak the functioning of a gene FGFR1. This gene is vital in the growth of embryos into adults. Their experiments were successful in the lab grown brain tissues and shows potential in therapeutics.

16 Jul 2019

New research shows significant gaps in deployment of 'coverage with evidence development'

Value in Health, the official journal of ISPOR- the professional society for health economics and outcomes research, announced today the publication of new research from The Netherlands showing important gaps in the deployment of "coverage with evidence development," a type of pharmaceutical managed entry agreement that gives patients access to treatments while additional evidence is being collected.

15 Jul 2019

Researchers identify potential drug target for multiple cancer types

A research team headed by scientists at University of California San Diego School of Medicine and the Ludwig Institute for Cancer Research at UC San Diego has identified an enzyme involved in remodeling the plasma membrane of multiple cancer cell types that is critical to both survival of tumors and their uncontrolled growth.

11 Jul 2019

HER2-positive breast cancer may be treated with imprinted nanospheres

A particularly aggressive, metastasizing form of cancer, HER2-positive breast cancer, may be treated with nanoscopic particles “imprinted” with specific binding sites for the receptor molecule HER2.

4 Jul 2019

Promising new approaches in the fight against brain metastasis

Research is currently pursuing several highly promising approaches in the fight against cancers that give rise to metastases in the brain.

28 Jun 2019

A metabolic intermediate in the uronic acid pathway impairs lung cancer metastasis

In a study published online in Nature on June 26, research teams led by Dr. YANG Weiwei at the Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences and Dr. LI Guohui from the Dalian Institute of Chemical Physics of CAS reported a new function of uridine diphosphate glucose (UDP-glucose), a metabolic intermediate in the uronic acid pathway: It impairs lung cancer metastasis by accelerating SNAI1 mRNA decay.

27 Jun 2019

New promising approach repairs system of blood vessels following stroke

Following a stroke, antibodies that inhibit the signaling molecule Nogo-A can help repair blood vessels in the affected brain regions.

25 Jun 2019

Switch that decides fate of cells from neural stem cells discovered

Neurons and astrocytes are prominent cell types in the cerebral cortex. Neurons are the primary information processing cells in the brain, whereas astrocytes support and modulate their functions.

24 Jun 2019

Researchers find a potential modulator in revascularization of pancreatic islets

The first cause of the loss of functionality in transplanted pancreatic islets is the low capacity to create new vessels to allow the arrival of nutrients in the cells.

20 Jun 2019

Study uncovers potential new way to prevent common pregnancy-related complications

About 1 in 10 pregnant women experience placenta abnormalities that lead to life-threatening preeclampsia (hypertension), preterm labor and fetal growth problems, but finding effective treatments to effectively prevent or reverse these conditions has so far been elusive.

19 Jun 2019

Novel lung map reveals new cells responsible for asthma

Researchers working on the Human Cell Atlas initiative have produced a detailed map of the human lungs that could lead to new treatments for asthma.

18 Jun 2019