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Novel approach: intranasal vaccination strategy targets Omicron COVID-19 variants

Researchers tested the efficacy of a two to three-dose intranasal (IN) regimen of the NDV-HXP-S vaccine.

14 Jul 2023

Macrophages may play a major role in the development of atrial fibrillation

Current treatments for atrial fibrillation (AFib), a common heart condition characterized by fast and irregular beats that can lead to stroke and heart failure, have multiple side effects and are ineffective for preventing AFib recurrence.

13 Jul 2023

IL-9 identified as contributor to viral spread and airway inflammation in COVID-19

Researchers used a K18-hACE2 transgenic (ACE2.Tg) mouse model to demonstrate that interleukin-9 (IL-9).

13 Jul 2023

Mouse model of Hutchinson-Gilford progeria syndrome shows reduction in hepatic H2S levels

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 12, entitled, "Hepatic hydrogen sulfide levels are reduced in mouse model of Hutchinson-Gilford progeria syndrome."

11 Jul 2023

How the brain keeps blood sugar levels in check

The body's blood glucose level needs to be maintained in a relatively narrow range. It cannot be too high, as it can lead to diabetes, and it cannot be too low because it can cause fainting or even death.

11 Jul 2023

New mouse model mimics the development of frailty in older adults

Researchers at the Johns Hopkins University School of Medicine have developed a mouse model that successfully mimics the development of frailty as mammals — likely including people — get older.

11 Jul 2023

The genetics of neurogenic inflammation in rosacea

Researchers identify rare genetic variants in families with rosacea.

11 Jul 2023

FKBP5 deficiency linked to atrial fibrillation

Atrial fibrillation (AFib) is the most common type of heart arrhythmia. This serious condition occurs when the heart beats so fast that the upper chambers of the heart quiver.

6 Jul 2023

New therapy to mitigate fragile X syndrome may be on the horizon

An antisense therapy developed by Joel D. Richter, PhD, Sneha Shah, PhD, and Jonathan K. Watts, PhD, at UMass Chan Medical School and Elizabeth Berry-Kravis, MD, PhD, at RUSH University Medical Center, restores production of the protein FMRP in cell samples taken from patients with fragile X syndrome.

5 Jul 2023

Researchers uncover the role of glutaminase 2 in glucose homeostasis

Glutaminase 2 (GLS2) is a master regulator of glutaminolysis. GLS2 converts glutamine to glutamate, thereby playing a role in cellular energy production. GLS2 is abundant in the liver, and is also found in pancreatic β-cells. However, the role of GLS2 in pancreatic islets – in which both ɑ- and β- cells are present – associated with glucose metabolism is currently unknown.

5 Jul 2023

Resistance training could be a simple and affordable therapy for Alzheimer's patients

Regular physical exercise, such as resistance training, can prevent Alzheimer's disease, or at least delay the appearance of symptoms, and serves as a simple and affordable therapy for Alzheimer's patients.

3 Jul 2023

Ancient retrovirus may be responsible for aggressive brain cancers

The median length of survival after diagnosis of glioblastoma is 14 months, but some of these brain tumors are more aggressive and resistant to treatment than others, and a new study from Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine suggests reactivation of an ancient retrovirus may be at least partly to blame.

3 Jul 2023

Cell therapy using genome-edited iPS cells could be a new treatment for Fabry disease

Induced pluripotent stem (iPS) cells have a great impact on biology and medicine, and they are expected to improve regenerative medicine.

3 Jul 2023

Spanish researchers develop new immunotherapy combination for liver cancer

Spanish researchers at Cima University of Navarra have developed a new immunotherapy combination that improves efficacy in animal models of hepatocellular carcinoma. This is a proof of concept that lays the foundations for the application of this treatment in patients with the most common liver cancer.

1 Jul 2023

Novel drug combination shows promise in treating pancreatic cancer

Mutations in the KRAS gene are the major driver of pancreatic cancer. The resulting protein controls multiple signaling pathways involved in cell growth and survival. In cancer, the gene is mutated to be permanently "on," driving cells to excessively multiply and form tumors.

28 Jun 2023

Mouse Model News and Research

Novel approach: intranasal vaccination strategy targets Omicron COVID-19 variants

Macrophages may play a major role in the development of atrial fibrillation

IL-9 identified as contributor to viral spread and airway inflammation in COVID-19

Mouse model of Hutchinson-Gilford progeria syndrome shows reduction in hepatic H2S levels

How the brain keeps blood sugar levels in check

New mouse model mimics the development of frailty in older adults

The genetics of neurogenic inflammation in rosacea

FKBP5 deficiency linked to atrial fibrillation

New therapy to mitigate fragile X syndrome may be on the horizon

Researchers uncover the role of glutaminase 2 in glucose homeostasis

Resistance training could be a simple and affordable therapy for Alzheimer's patients

Ancient retrovirus may be responsible for aggressive brain cancers

Cell therapy using genome-edited iPS cells could be a new treatment for Fabry disease

Spanish researchers develop new immunotherapy combination for liver cancer

Novel drug combination shows promise in treating pancreatic cancer

GREB1 gene key to liver cancer development, study finds

Study reveals neural circuits underlying adolescent stress-induced postpartum social behavior

Scientists uncover molecular mechanism contributing to defective heart development in Down syndrome

Research explains mechanisms behind anti-viral protection in hemochorial placentas

Oral probiotic bacterial strain found to improve dry eye disease in animal model

Industry Focus eBook - Cell biology (5th edition) eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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