Immune System News and Research

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UVA researchers discover unexpected interaction between men's testes and immune system

The University of Virginia School of Medicine has again shown that a part of the body thought to be disconnected from the immune system actually interacts with it, and that discovery helps explain cases of male infertility, certain autoimmune diseases and even the failure of cancer vaccines.

25 Mar 2017

Combination of high-intensity ultrasound and immunotherapy may be effective in treating cancer

In a new study published today in JCI Insight, UC Davis researchers have shown that combining high-intensity focused ultrasound with two immunotherapies (a PD-1 checkpoint inhibitor and TLR9 agonist) can produce excellent response rates in mouse models of epithelial cancer.

25 Mar 2017

Immunotherapy drug becomes first FDA-approved treatment for metastatic MCC

The U.S. Food and Drug Administration yesterday granted accelerated approval to the checkpoint inhibitor Bavencio (avelumab) for the treatment of patients with metastatic Merkel cell carcinoma (MCC), including those who have not received prior chemotherapy.

25 Mar 2017

Exposure to acrolein causes failure of immune defence to tumours, study finds

The World Health Organisation estimates that every year 600,000 deaths are caused by passive smoking worldwide and, in Austria alone, two or three people a day die as a result of passive smoking.

25 Mar 2017

Scientists discover potential role for 'jumping genes' in ALS

By inserting an amyotrophic lateral sclerosis (ALS)-linked human gene called TDP-43 into fruit flies, researchers at Stony Brook University and Cold Spring Harbor Laboratory discovered a potential role for 'transposons' in the disease.

24 Mar 2017

Review provides new understanding of cytokine mediated effects on inflammatory disorders

Researchers studying chronic inflammation that can lead to the development of lung diseases such as asthma, pulmonary fibrosis, and cancer, are focusing on the role cytokines play in regulating the behavior of fibroblast cells and the extracellular matrix.

24 Mar 2017

One-shot vaccine passes key preclinical test in newborn monkey models

Newborns are highly vulnerable to infections and don't respond optimally to most vaccines because their young immune systems typically mount weak antibody responses.

24 Mar 2017

Study reveals intriguing crosstalk between metabolism and epigenetics in cancer development

A study published in Briefings in Functional Genomics investigated how epigenetics can modulate human's genetic program -- it can emphasize or silence genes.

24 Mar 2017

New research reveals surprising culprit involved in self-destruction of axons

In many neurodegenerative conditions — Parkinson's disease, amyotrophic lateral sclerosis (ALS) and peripheral neuropathy among them — an early defect is the loss of axons, the wiring of the nervous system.

24 Mar 2017

FDA grants accelerated approval to new drug for treatment of rare form of skin cancer

The U.S. Food and Drug Administration today granted accelerated approval to Bavencio (avelumab) for the treatment of adults and pediatric patients 12 years and older with metastatic Merkel cell carcinoma (MCC), including those who have not received prior chemotherapy.

23 Mar 2017

Researchers unravel how drug interacts with ribosome to halt protein production

The discovery of a chemical compound that halts the production of a small set of proteins while leaving general protein production untouched suggests a new drug search strategy: Find compounds that target undesired proteins before they are even made.

23 Mar 2017

Discovery about retinal zinc may show new way to protect, regenerate optic nerve in glaucoma patients

Connecting pieces of information by finding a common thread often takes glaucoma researchers in unexpected directions.

23 Mar 2017

Analysis of antibodies could be new tool for predicting prognosis and choosing therapy for RA patients

In rheumatoid arthritis, antibodies are formed that affect the inflammation in the joints. In an article published today in the journal Annals of the Rheumatic Diseases, researchers at Uppsala University show that antibodies against the cartilage protein collagen II are associated with a good prognosis.

23 Mar 2017

Intratumoral vaccination prolongs survival in mouse model of early stage resected pancreatic cancer

Building on their previous research focusing on vaccination within a tumor (intratumoral) for the most common form of pancreatic cancer, investigators from Rutgers Cancer Institute of New Jersey and Rutgers Robert Wood Johnson Medical School have shown that in a mouse model of early stage resected pancreatic cancer, intratumoral vaccination induces an anti-tumor response that results in a significant improvement in overall survival.

23 Mar 2017

Penn researcher receives $16.3 million NIAID grant to develop long-sought-after HIV vaccine

Building on earlier work in designing chimeric human-simian immunodeficiency viruses (SHIVs) that serve as a model of HIV infection of humans, George M. Shaw, MD, PhD, a professor of Hematology/Oncology and Microbiology in the Perelman School of Medicine at the University of Pennsylvania, has received $16.3 million over five years from the National Institute of Allergy and Infectious Diseases to develop a long-sought-after HIV vaccine.

22 Mar 2017

Researchers find new way to expand, preserve cord-blood cells as potential treatment for Type 1 diabetes

For parents, storing their newborn baby's umbilical cord blood is a way to preserve potentially lifesaving cells. Now, a group of University of Florida Health researchers has found a way to expand and preserve certain cord-blood cells as a potential treatment for Type 1 diabetes.

22 Mar 2017

Immune System News and Research

UVA researchers discover unexpected interaction between men's testes and immune system

Combination of high-intensity ultrasound and immunotherapy may be effective in treating cancer

Immunotherapy drug becomes first FDA-approved treatment for metastatic MCC

Exposure to acrolein causes failure of immune defence to tumours, study finds

Scientists discover potential role for 'jumping genes' in ALS

Review provides new understanding of cytokine mediated effects on inflammatory disorders

One-shot vaccine passes key preclinical test in newborn monkey models

Study reveals intriguing crosstalk between metabolism and epigenetics in cancer development

New research reveals surprising culprit involved in self-destruction of axons

FDA grants accelerated approval to new drug for treatment of rare form of skin cancer

Researchers unravel how drug interacts with ribosome to halt protein production

Discovery about retinal zinc may show new way to protect, regenerate optic nerve in glaucoma patients

Analysis of antibodies could be new tool for predicting prognosis and choosing therapy for RA patients

Intratumoral vaccination prolongs survival in mouse model of early stage resected pancreatic cancer

Penn researcher receives $16.3 million NIAID grant to develop long-sought-after HIV vaccine

Researchers find new way to expand, preserve cord-blood cells as potential treatment for Type 1 diabetes

Researchers provide better understanding of the body's immune responses to implanted materials

ECDC guidance aims to improve antenatal screening for infections to avoid mother-to-child transmission

Use of FTIR spectroscopy could herald fast and easy way to spot early signs of disease

Efficacy of innovative gene therapy can be tested quickly and cost-effectively using new cellular model

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