Animal Model News and Research

RSS

Research shows the potential of structural nanomedicine in cancer treatment

In a promising advance for cancer treatment, Northwestern University scientists have re-engineered the molecular structure of a common chemotherapy drug, making it dramatically more soluble and effective and less toxic.

29 Oct 2025

Psoriasis-linked gene mutation may also play a surprising role in gut health

A mutation previously linked to skin disorders like psoriasis may also play a surprising role in gut health, according to new research published by scientists at VIB-UGent and colleagues from UGent, the University of Barcelona, and University College London.

23 Oct 2025

Microbial genetic variation shapes neurocognitive behavior in sheep

The researchers used Merino sheep as an animal model, systematically collecting samples of their hindgut and ruminal microbiota, plasma metabolites, and neurocognitive behavioral phenotype data.

10 Oct 2025

Optogenetics and artificial intelligence open path to personalized Parkinson’s treatment

Globally recognized figures like Muhammad Ali and Michael J. Fox have long suffered from Parkinson's disease. The disease presents a complex set of motor symptoms, including tremors, rigidity, bradykinesia, and postural instability.

26 Sep 2025

Scientists study how nanoplastics transfer across generations

You can't see nanoplastics with the naked eye, but they're everywhere - including your body.

23 Sep 2025

PRMT5 inhibition induces ferroptosis and enhances immunotherapy efficacy in renal cell carcinoma

Ferroptosis, a regulated cell death mechanism, is emerging as a promising target for cancer therapy. The process is mediated by the activity of acyl-CoA synthetase family member 4 (ACSL4) protein.

22 Sep 2025

Electrical stimulation predicts recovery potential after acute nerve injuries

This study found that, in rats, acute nerve injuries that may recover can be distinguished from those that are unlikely to recover based on the response to intraoperative electrical nerve stimulation in the acute clinical setting.

13 Sep 2025

GABA identified as key blocker of neural repair in spinal cord injury

Spinal cord injuries caused by external trauma, such as traffic accidents or falls, often lead to the permanent loss of motor and sensory functions.

10 Sep 2025

Amino acid homocysteine plays a key role in aortic stiffening

In addition to cholesterol, the amino acid homocysteine also plays a role in aortic stiffening. Researchers from Graz University of Technology, the University of Graz and the Medical University of Graz were able to prove this in a new study.

9 Sep 2025

Scientists uncover human proteins hijacked by SARS-CoV-2 for replication

Despite vaccines and treatments, SARS-CoV-2-the virus that causes COVID-19-continues to pose a global health threat, driven by new variants and its ability to hijack human cells in ways that still aren't fully understood.

5 Sep 2025

Targeting complement with an inhibitor may prevent preterm birth and protect the baby’s brain

A research team at the Medical University of South Carolina reports in Cells that the complement system, part of the body's natural immune defenses, is a key driver of inflammatory responses that contribute to fetal brain inflammation and preterm birth, the latter of which is the leading cause of complications and death in newborns.

4 Sep 2025

Neuritin 1 unlocks new pathway to treat obesity without reducing food intake

Is it possible to treat obesity without reducing food intake? A new study co-led by Dr. Antonio Zorzano and Dr. Manuela Sánchez-Feutrie at the Institute for Research in Biomedicine (IRB Barcelona) suggests that this might be a possibility, at least in animal models.

4 Sep 2025

Chronic stress and fatty diet disrupt brain-liver circuit leading to diabetes

This study discovered a circuit in the brain that connects stress with increased glucose and therefore may link stress to type 2 diabetes. In stressful situations, this circuit from the amygdala to the liver naturally provides a burst of energy.

3 Sep 2025

Male and female bovine embryos show distinct development paths

Cornell researchers have uncovered the genetic triggers that cause male and female bovine embryos to develop differently, as early as seven to eight days after fertilization.

29 Aug 2025

Stanford scientists make mouse skin transparent to study brain development

During childhood and adolescence, our brain goes through a lot of changes. But studying those changes in juvenile mice is challenging because scientists don't have a way to repeatedly image the same animal's neural pathways as they grow.

28 Aug 2025

Certain dietary fats found to trigger hard-to-treat asthma in children

Researchers at Children's Hospital of Philadelphia (CHOP) found that certain lipids, or fats, in obesity-causing foods also cause asthma-like lung inflammation.

27 Aug 2025

New mouse model reveals key role of osteocytes in osteogenesis imperfecta

Osteogenesis imperfecta (OI) refers to a group of rare genetic bone disorders that results in the formation of fragile bones. In patients with OI, the matrix that makes up the bone has been found to be abnormal, leading to an increased risk of fractures.

13 Aug 2025