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Combined DNA and protein 'liquid biopsy' more accurate in identifying early-stage pancreatic cancer

Johns Hopkins scientists say they have developed a blood test that spots tumor-specific DNA and protein biomarkers for early-stage pancreatic cancer.

4 Sep 2017

Cancer drug may inhibit growth of cysts in patients with inherited form of kidney disease

A cancer drug called bosutinib may inhibit the growth of cysts in patients with autosomal dominant polycystic kidney disease (ADPKD), according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology.

24 Aug 2017

Researchers uncover how mutations in single gene lead to rare kidney and liver disease

In a joint international study, researchers from Osaka University have partnered with research groups from the United States and Spain to uncover how mutations in a single gene called PKHD1 lead to symptoms associated with a rare kidney and liver disease, ARPKD (autosomal recessive polycystic kidney disease).

24 Aug 2017

Two-test combination accurately identifies benign pancreatic lesions

When performed in tandem, two molecular biology laboratory tests distinguish, with near certainty, pancreatic lesions that mimic early signs of cancer but are completely benign.

23 Jun 2017

NIBIB-funded scientists develop rapid and accurate tool for detecting early pancreatic cancer

Researchers funded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) have developed a new tool for detecting early pancreatic cancer.

17 May 2017

Scientists identify unusual mutations in endometriosis using gene sequencing tools

Using gene sequencing tools, scientists from Johns Hopkins Medicine and the University of British Columbia have found a set of genetic mutations in samples from 24 women with benign endometriosis, a painful disorder marked by the growth of uterine tissue outside of the womb.

11 May 2017

Researchers develop fruit fly-based model to improve understanding of polycystic kidney disease

According to PKD International, 12.5 million people are affected by polycystic kidney disease. There is no known cure. But that may one day change, thanks in part to new research by a Concordia biology researcher.

2 May 2017

New light-scattering tool helps doctors to accurately identify malignant pancreatic cysts

Pancreatic cancer has the lowest survival rate among all major cancers, largely because physicians lack diagnostic tools to detect the disease in its early, treatable stages.

13 Mar 2017

New method to generate kidney organoids from patient cells can help study human kidney diseases

A new method to create kidney organoids from patient cells may provide insights into how kidney diseases arise and how they should be treated.

18 Nov 2016

Interpace Diagnostics introduces new AccuCEA Insights for diagnosing and treating pancreatic cancer

Interpace Diagnostics Group, a company that provides clinically useful molecular diagnostic tests and pathology services for evaluating risk of cancer by leveraging the latest technology in personalized medicine for better patient diagnosis and management, reported today that the Company has launched a new version of their AccuCEA™ product called "Insights" for Gastroenterologists who focus on diagnosing and treating pancreatic cancer.

24 Aug 2016

New series of treatments may provide another option for families of unborn babies with CPAM

A medical team at Osaka University Hospital, Japan, has conducted successful treatment for the fetal lung disorder Congenital Pulmonary Airway Malformattion (CPAM), also known as Congenital Cystic Adenomatoid Malformation (CCAM).

28 Jul 2016

Pancreatic cysts increase overall risk of pancreatic cancer, study shows

A look back at more than half a million patient records has established that patients with pancreatic cysts have a significantly higher overall risk of pancreatic cancer compared to those without such cysts, according to a study in the July issue of GIE: Gastrointestinal Endoscopy, the journal of the American Society for Gastrointestinal Endoscopy.

12 Jul 2016

Virtual tissue technology helps identify new drug target to combat polycystic kidney disease

Using virtual tissue technology, researchers at Indiana University have identified a potential new drug target in the fight against polycystic kidney disease, an illness with no effective FDA-approved treatment that affects 200,000 people per year in the United States.

28 Jun 2016

Novel drug shows promise against metastatic breast cancer in mouse models

12 Jan 2016

Novel drug shows promise in mouse models of human metastatic breast cancer

A doctor treating a patient with a potentially fatal metastatic breast tumor would be very pleased to find, after administering a round of treatment, that the primary tumor had undergone a change in character - from aggressive to static, and no longer shedding cells that can colonize distant organs of the body. Indeed, most patients with breast and other forms of cancer who succumb to the illness do so because of the cancer's unstoppable spread.

23 Dec 2015

CRISPR/Cas9 turns hPSCs into cell-based lab model system for polycystic kidney disease

CRISPR/Cas9 is hot. News of the revolutionary gene editing technique that is already shaking up bioscience has finally reached the news media and the public. Now comes a first rate example of how CRISPR is changing the pace of biomedical research by linking up with another cutting edge technology -- human pluripotent stem cells (hPSCs).

12 Dec 2015

Johns Hopkins scientists use gene-based tests to distinguish precancerous cysts from harmless cysts

In a "look-back" analysis of data stored on 130 patients with pancreatic cysts, scientists at Johns Hopkins have used gene-based tests and a fixed set of clinical criteria to more accurately distinguish precancerous cysts from those less likely to do harm. The findings may eventually help some patients in real time safely avoid surgery to remove harmless cysts.

18 Nov 2015

New article highlights advantages of nCLE technique for characterization of pancreatic cysts

Mauna Kea Technologies, inventor of Cellvizio, the multidisciplinary confocal laser endomicroscopy platform, today announced that the peer-reviewed journal Surgical Endoscopy has released a new article highlighting the advantages of needle-based confocal laser endomicroscopy (nCLE) for characterization of different types of pancreatic cysts.

22 Oct 2015

Mercy open new Endoscopy Suite to promote and practice gastrointestinal health

Mercy Medical Center has announced the opening of a new, state-of-the-art Endoscopy Suite to promote and practice gastrointestinal health. The unique, high-tech suite is located on the 2nd floor of Mercy's Mary Catherine Bunting Center at 345 St. Paul Place. Bunting Endoscopy will be under the direction of Dr. Paul J. Thuluvath, Medical Director of The Melissa L. Posner Institute for Digestive Health & Liver Disease at Mercy.

6 Oct 2015

Fetuses with enlarged ventricles are not ideal candidates for fetal spina bifida surgery

Fetuses with enlarged ventricles--the fluid-filled cavities inside the brain--may be less likely than other fetuses to benefit from surgery in the womb to treat spina bifida, according to a study co-authored by researchers at UCSF Benioff Children's Hospital San Francisco.

16 Sep 2015