DNA Damage News and Research

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ERC Proof of Concept grant supports promising CRISPR-based cancer treatment research

Microbiologist John van der Oost of Wageningen University & Research (WUR) has received an ERC Proof of Concept grant to further develop a promising CRISPR-based approach to cancer treatment. With funding of €150,000, he and researcher Christian Südfeld will spend the next eighteen months working on a method to kill cancer cells from within, while sparing healthy cells as much as possible.

30 Jan 2026

DNA repair enzyme failure triggers inflammation and accelerates aging in cells

If severe DNA damage is not repaired, the consequences for the health of cells and tissues are dramatic.

30 Jan 2026

Biomarker discovery may pave the way for early diagnosis of Parkinson's

A team led by researchers at Chalmers University of Technology, Sweden, has succeeded in identifying biomarkers for Parkinson's disease in its earliest stages, before extensive brain damage has occurred.

29 Jan 2026

Super-enhancers: Cancer's double-edged sword of growth and DNA damage

New study shows that cancer damages its own DNA by pushing key genes to work too hard. Researchers found that the most powerful genetic "on switches" in cancer cells, called super-enhancers, drive unusually intense gene activity.

22 Jan 2026

Sperm RNA aging shift that may explain paternal age effects

Study reveals an 'aging cliff' in sperm RNA, linking age-related changes to early development and highlighting risks associated with advanced paternal age.

22 Jan 2026

Study identifies PUF60 as a critical vulnerability in triple negative breast cancer

Researchers at University of California San Diego have identified a previously unrecognized treatment target for triple‑negative breast cancer (TNBC), the most aggressive subtype of breast cancer.

12 Jan 2026

Whole-genome sequencing improves PARP inhibitor treatment prediction

A whole-genome sequencing approach shows early promise over current commercial methods for identifying more patients likely to benefit from PARP inhibitor cancer treatments, according to a study led by Weill Cornell Medicine and NewYork-Presbyterian investigators.

12 Jan 2026

ICSA 2025: Infection's role in cellular senescence, inflammation, and aging

A new meeting report was published in Volume 17, Issue 12 of Aging-US on December 23, 2025, titled "Cellular senescence meets infection: highlights from the 10th annual International Cell Senescence Association (ICSA) conference, Rome 2025."

8 Jan 2026

Ancient animals reveal sleep’s original role in maintaining brain health

A groundbreaking new study from Bar-Ilan University shows that one of sleep's core functions originated hundreds of millions of years ago in jellyfish and sea anemones, among the earliest creatures with nervous systems.

6 Jan 2026

RNA splicing and processing genes emerge as central drivers of aging across tissues

A new research paper featured as the cover of Volume 17, Issue 12 of Aging-US was published on December 22, 2025, titled "A combination of differential expression and network connectivity analyses identifies a common set of RNA splicing and processing genes altered with age across human tissues."

5 Jan 2026

Study uncovers how aggressive breast cancer cells escape immune defenses

With a new study in the journal Science Bulletin, researchers at Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University have discovered a new way that aggressive breast cancer cells escape the immune defenses.

1 Jan 2026

Targeting CSE enzyme may offer new pathways for Alzheimer’s treatment

Scientists at Johns Hopkins Medicine say results of a new National Institutes of Health-funded study are advancing efforts to exploit a new target for Alzheimer's disease: a protein that manufactures an important gas in the brain.

30 Dec 2025

Study reveals a therapeutic vulnerability in aggressive subtype of triple-negative breast cancer

A new study published today in Science Translational Medicine by researchers at The University of Texas MD Anderson Cancer Center details a therapeutic vulnerability in patients with an aggressive subtype of triple-negative breast cancer.

26 Dec 2025

Wasatch Biolabs announces co-marketing agreement with Agilent to advance native-read targeted sequencing

Wasatch BioLabs (WBL), a leader in native, long-read sequencing and epigenomic analysis, today announced a co-marketing agreement with Agilent Technologies to support the adoption of its Direct Targeted Methylation Sequencing (dTMS) platform.

From Wasatch BioLabs 22 Dec 2025

New insights into alcohol-related DNA damage and cancer risk

Alcohol consumption leads to the formation of a toxic compound called acetaldehyde, which damages DNA.

15 Dec 2025

New research reveals the impact of DNA-histone cross-links on genome stability

DNA–protein cross-links (DPCs) represent a severe form of DNA damage that can disrupt essential chromatin-based processes. Among them, DNA–histone cross-links (DHCs) occur frequently within nucleosomes, yet their structural and functional consequences remain poorly understood due to their instability and low natural abundance.

13 Dec 2025

Researchers discover the enzyme responsible for chromothripsis in cancer

University of California San Diego researchers have discovered the enzyme responsible for chromothripsis, a process in which a single chromosome is shattered into pieces and rearranged in a scrambled order, allowing cancer cells to rapidly evolve and become resistant to treatment.

11 Dec 2025