Glutamine News and Research

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Glutamine is an amino acid used in nutrition therapy. It is also being studied for the treatment of diarrhea caused by radiation therapy to the pelvis.

Indirect inhibitors of cellular respiration for treatment of glioblastoma

A new research perspective was published in Oncotarget's Volume 14 on May 4, 2023, entitled, "Targeting cellular respiration as a therapeutic strategy in glioblastoma."

19 May 2023

New insight into mechanisms underlying hippocampal atrophy in individuals at risk for psychosis

Dysregulation of the dopamine neurotransmitter system has long been associated with schizophrenia and other forms of psychosis, but recently researchers have begun to examine the glutamate and GABA systems as well.

12 May 2023

Targeting the hemoglobin problem in sickle cell disease using a new drug

A class of drugs used for their ability to stop tumor cells from dividing is now under study for their potential to reduce the pain and damage caused by sickle cell disease, investigators report.

11 May 2023

Ketogenic diet: A metabolic makeover boosting immunity and battling inflammation

A recent study discusses alterations in the human metabolic fingerprint associated with the keto diet.

8 May 2023

The dynamics and interactions between the skin metabolome, microbiome, and UV exposure

Researchers evaluated metabolic profile changes of the skin in relation to microbiota and UV exposure.

5 May 2023

The relationship between intestinal microbiome dysbiosis and atherosclerosis

Researchers investigate the impact of intestinal microbiota dysbiosis on atherosclerotic cardiovascular disease incidence.

15 Mar 2023

Age and sex determine the effects of microbiota on mice's metabolome

The gut handles all ingested foods for further digestion and assimilation. In addition, it harbors a wealth of microbes that produce metabolic byproducts with multiple effects on host physiology. Therefore, changes in the gut microbiome's composition can shift the gut's metabolome as well.

15 Mar 2023

Many individuals living with sickle cell disease still lack access to new pain medications

Sickle cell disease (SCD), a rare chronic, progressive, life-threatening, inherited blood disorder, often affects individuals with chronic pain that can be debilitating to their quality of life.

9 Mar 2023

Mass spectrometry-based identification of COVID-19 biomarkers

In a recent study published in the journal Metabolites, researchers reported that mass spectrometry (MS)-based metabolomic approaches have a high potential for biomarker discovery.

28 Feb 2023

What is the effect of maternal circulating amino acids on offspring birthweight?

Researchers examined the effect of serum levels of 20 amino acids in a mother during pregnancy on offspring birthweight in a two-sample summary data Mendelian randomization framework.

27 Feb 2023

Dietary polyphenols may play a role in regulating inflammatory immune responses

PCB2DG, a polyphenol with anti-inflammatory properties, works by targeting and directly interacting with the major glutamine transporter protein, alanine serine cysteine transporter 2 (ASCT2), to inhibit the uptake of glutamine, an important amino acid found in the blood.

22 Feb 2023

Process analytical technologies and monitoring inline R&D biopharma processes with Raman spectroscopy

Established in 2004, process analytical technology (PAT), a quality assurance program for the pharmaceutical industry developed by the US Food and Drug Administration, enables pharmaceutical manufacturers to control critical process parameters (CPPs).

From Thermo Fisher Scientific – Pharmaceutical and Biopharmaceutical Solutions 25 Jan 2023

Novel prion strain causes chronic wasting disease in a Finland moose

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19 Jan 2023

Are dysregulated metabolism and inflammation contributing factors to the ongoing symptoms in long-term COVID-19 syndrome patients?

Researchers reported that dysregulation in energy metabolism and inflammation could contribute to long-term COVID-19 syndrome.

19 Jan 2023

Researchers develop an artificial neuron closely mimicking the characteristics of a biological neuron

Researchers reported a conductance-based organic electrochemical neuron that mimicked biological signaling in neurons, especially activation/inactivation of their sodium and potassium channels.

16 Jan 2023

Study implicates gut microbiome health in Parkinson's disease

A new study published in the journal Nature Communications discusses the links between this condition that affects the brain and changes in the gut microbiome that may predate brain changes.

1 Dec 2022

Research finds higher rate of rare tandem repeats in the genomes of individuals with schizophrenia

In our cells, the language of DNA is written, making each of us unique. A tandem repeat occurs in DNA when a pattern of one or more nucleotides – the basic structural unit of DNA coded in the base of chemicals cytosine (C), adenine (A), guanine (G) and thymine (T) – is repeated multiple times in tandem. An example might be: CAG CAG CAG, in which the pattern CAG is repeated three times.

30 Nov 2022

New guidelines for designing synthetic molecules that block interaction between two proteins

Inside cells, proteins constantly interact with each other to carry out different functions. For some diseases in which these functions are altered, blocking the binding between two or more proteins emerges as a possible therapeutic approach.

30 Nov 2022

Gut microbiome in mice gets stressed within 24 hours on a high-fat diet

In a recent study published in the journal Cell Reports, researchers in Cincinnati, USA, assessed the impact of dietary alteration to a high-fat diet (HFD) on the intestine.

17 Nov 2022

Augmented drug preferentially eliminates cancer cells but does not harm healthy cells

Johns Hopkins Medicine researchers have revamped an anti-cancer drug to better target cancer cells and leave healthy tissues unharmed. Scientists have dubbed this type of targeted approach a "prodrug" - a medicine designed to release its payload in a particular area of the body and in no other areas.