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Exploring human milk oligosaccharides as a method of COVID-19 prevention

New research was conducted to ascertain whether antiviral and immunomodulatory activities of human milk oligosaccharides can be efficacious in the prevention and treatment against COVID-19.

3 Feb 2022

The Role of Glycans in the Cell and Glycans Imaging Method

In this interview, News-Medical talks to a pioneer of glycan imaging, Richard Drake about glycans, their role in maintaining cellular homeostasis, glycopeptide analysis, and method development for glycan imaging.

From Bruker Life Sciences Mass Spectrometry 26 Jan 2022

Study reports of receptor-binding domain multimer capable of enhancing the immune response against SARS-CoV-2

Researchers have discovered a new way to induce immunity against the RBD.

19 Jan 2022

Scientists provide a structural framework for Omicron immune evasion and ACE2 receptor recognition

An interesting preprint research paper describes structural changes resulting from the multiple mutations found in the recent Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 is the causative agent behind the coronavirus disease 2019 (COVID-19) pandemic. In addition, the research describes the consequent effects of these changes on Omicron’s infectivity and immune evasion capabilities.

5 Jan 2022

Clinical-grade soluble human ACE2 shown to inhibit SARS-CoV-2 Omicron variant

New study findings show that the clinical-grade soluble ACE2 effectively inhibits the SARS-CoV-2 Omicron variant, which proves the principle of an effective therapeutic approach against Omicron-driven COVID-19 infections.

30 Dec 2021

Production of functional SARS-CoV-2 spike protein in single-cell green alga

A new study uses a novel algal platform for the generation of the SARS-CoV-2 spike protein.

19 Dec 2021

Comparison of RBD/ACE2 receptor complex in wild type SARS-CoV-2 and Omicron variant

New research details the molecular landscape of Omicron’s RBD and how it differs from the original SARS-CoV-2 strain.

17 Dec 2021

Glycans strengthen interaction between viral spike proteins and ACE2 receptors on host cells

A new study shows that the ACE2 and RBD of coronavirus spike fragments have different binding strengths and dissociation rates when they are glycosylated and non-glycosylated.

13 Dec 2021

Glycans strengthen and lengthen SARS-Cov-2 spike binding to ACE2

New study results provide evidence that the binding between SARS-CoV-2 RBD and host ACE2 receptor is aided by the glycosylation on each protein.

9 Dec 2021

Equilibrium simulation of SARS-CoV-2 spike protein highlights its global conformational characteristics

A team of researchers set out to build a full-length, membrane-embedded spike to study its conformational dynamics at the atomic level using molecular dynamics simulations to understand better how this important component of the virus machinery works.

8 Dec 2021

Impact of post-translational modifications in the pathogenicity of SARS-CoV-2

A new study provides understanding of the intricate roles and functions of the different elements of spike proteins and shows how the spike protein samples a crowded surface of its host cell via the glycans.

7 Dec 2021

Glycosylation and disulfide bonding profile of SARS-CoV-2 spike glycoprotein

Researchers found that virus-like particles produced by co-expression of SARS-CoV-2 S, membrane, envelope, and nucleocapsid proteins contain S glycoproteins, which are modified by complex carbohydrates.

29 Nov 2021

Antigenic cocktail produced in Nicotiana benthamian plant as a potential COVID-19 vaccine candidate

Scientists utilize N. benthamiana for producing the N-protein and an antigenic cocktail containing the N-protein and SARS-CoV-2 S RBD.

23 Nov 2021

Functions of glycosylation in SARS-CoV-2 proteins and human receptor ACE2

In a review published in Signal Transduction and Targeted Therapy, researchers from Sichuan University have reviewed the available literature.

19 Nov 2021

New atomic-level insight of SARS-CoV-2 within a respiratory aerosol

In a paradigm-shifting paper currently available on the bioRxiv* preprint server, the researchers have dramatically extended the possibilities of computational microscopy in order to better understand both structure and dynamics of respiratory aerosols laden with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

16 Nov 2021

Sexually dimorphic placental antibody transfer during SARS-CoV-2 infection

In a paper recently published in the journal Science Translational Medicine by Bordt et al. (October 19th, 2021), maternal SARS-CoV-2 infections are studied with particular regard to maternal-fetal antibody transfer and virus-induced placental interferon responses, finding a sexually dimorphic response that results in lesser antibody transfer to the male fetus.

26 Oct 2021

Glycans News and Research

Exploring human milk oligosaccharides as a method of COVID-19 prevention

The Role of Glycans in the Cell and Glycans Imaging Method

Study reports of receptor-binding domain multimer capable of enhancing the immune response against SARS-CoV-2

Scientists provide a structural framework for Omicron immune evasion and ACE2 receptor recognition

Clinical-grade soluble human ACE2 shown to inhibit SARS-CoV-2 Omicron variant

Production of functional SARS-CoV-2 spike protein in single-cell green alga

Comparison of RBD/ACE2 receptor complex in wild type SARS-CoV-2 and Omicron variant

Glycans strengthen interaction between viral spike proteins and ACE2 receptors on host cells

Glycans strengthen and lengthen SARS-Cov-2 spike binding to ACE2

Equilibrium simulation of SARS-CoV-2 spike protein highlights its global conformational characteristics

Impact of post-translational modifications in the pathogenicity of SARS-CoV-2

Glycosylation and disulfide bonding profile of SARS-CoV-2 spike glycoprotein

Antigenic cocktail produced in Nicotiana benthamian plant as a potential COVID-19 vaccine candidate

Functions of glycosylation in SARS-CoV-2 proteins and human receptor ACE2

New atomic-level insight of SARS-CoV-2 within a respiratory aerosol

Sexually dimorphic placental antibody transfer during SARS-CoV-2 infection

New technology to detect SARS-COV-2 using sugars rather than antibodies

Researchers uncover how cancer cells use sugar residue to evade the immune system

How SARS-CoV-2 spike binds to multiple host receptors

Structure-based model of SARS-CoV-2 spike protein reveals opportunity to halt virus transmission

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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