Glycans News and Research

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The diverse mechanisms by which galectins can regulate adaptive and innate immune responses

Researchers explored ways galectins can impact immunity and discussed the opportunities and challenges in the field.

18 Jan 2023

Recent findings on original antigenic sin and SARS-CoV-2

Researchers collated the findings of studies relating original antigenic sin with SARS-CoV-2 evolution.

13 Jan 2023

Technical advances expand the application of mass spectrometry imaging in pharmaceutical research

Announcing a new publication for Acta Materia Medica journal. Mass spectrometry imaging (MSI) has been shown to be a valuable tool through nearly every stage of the preclinical drug research and development (R&D) pipeline, and even to the early phase of clinical pharmaceutical evaluation.

3 Jan 2023

Bacterial outer membrane vesicles: utility as vaccines and novel engineering approaches

Scientists have described the utility of gram-negative bacteria-derived outer membrane vesicles as vaccines and methods to expand their applications.

3 Jan 2023

Scientists identify molecules in mucus that can block cholera infection

MIT researchers have identified molecules found in mucus that can block cholera infection by interfering with the genes that cause the microbe to switch into a harmful state.

13 Dec 2022

Antibodies against gentamicin associated with increased risk of type 1 diabetes in children

Antibodies produced against the commonly used antibiotic, gentamicin, appear to increase the risk of type 1 diabetes in children already genetically at risk, scientists say.

8 Dec 2022

Glycan signatures in rheumatic diseases and their associated functional implications

A new paper examines the understanding of glycosylation in an array of rheumatic diseases and indicates the potential for therapeutic interventions using the same mechanism.

28 Nov 2022

Potent hypervalent nanoparticles against HIV, Lassa and SARS-CoV-2 variants

In a recent study published in the journal Advanced Science, researchers developed molecularly imprinted nanoparticles (nanoMIPs) with broad-spectrum activity against lethal viruses.

21 Nov 2022

Why we should all eat Kimchi and other Korean fermented foods

A recent study reviews various traditional Korean fermented foods for their various health benefits.

20 Nov 2022

Scientists map structure of the hepatitis C virus E1E2 glycoprotein complex

A team led by scientists at Scripps Research and the University of Amsterdam has achieved an important goal in virology: mapping, at high resolution, critical proteins that stud the surface of the Hepatitis C virus (HCV) and enable it to enter host cells.

20 Oct 2022

Vaccine-induced neutralizing and non-neutralizing antibody activity against SARS-CoV-2

A new study demonstrated that vaccine-induced antibody functions against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diminish with age.

7 Oct 2022

Antibody escape mutations of SARS-CoV-2 BA.2.75

A new study discusses how immune escape mutations allow a recent SARS-CoV-2 variant to evade neutralizing antibodies and cause breakthrough infections.

4 Oct 2022

What is the role of N-glycans and calnexin-calreticulin chaperones in SARS-CoV-2 spike maturation?

A new study showed that SARS-CoV-2 Spike N-glycosylation patterns, intracellular lectins, and the associated molecular chaperones play crucial roles in the viral-host-cell invasion and function.

28 Sep 2022

Specific N-glycans regulate the development and functional maturation of SARS-CoV-2 spike protein

If you're an avid reader of science news, you've probably heard of viral proteins such as the COVID-19 spike protein.

27 Sep 2022

New antiviral mechanism of action for an FDA-approved thiopurine known as 6-thioguanine

Researchers described a novel antiviral mechanism of action for an FDA (food and drug administration)-approved thiopurine known as 6-thioguanine (6-TG).

21 Sep 2022

O-linked sialoglycans affect SARS-CoV-2 spike cleavage

In a recent study posted to the bioRxiv* preprint server, researchers from Spain, the United Kingdom, and the United States used chemical tools to uncover the molecular details of glycan-mediated modulation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) processing.

19 Sep 2022

What is the impact of COVID-19 treatments targeting intracellular Neu1?

In a new study, researchers assessed the impact of targeting intracellular Neu1 on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

14 Sep 2022

Exploration of glycan shield structure of sarbecoviruses provides new insights into developing pan-coronavirus vaccines

A new study explored the glycan shield diversity of sarbecoviruses, furthering the knowledge for developing broad-range pan-coronavirus vaccines.

30 Aug 2022

How natural alterations inside the SARS-CoV-2 glycan barrier affect spike protein dynamics

Researchers explored how the natural alterations inside the SARS-CoV-2 glycan barrier affect the spike protein dynamics.

22 Aug 2022

Study paves new way to develop a predictive biomarker for TRAIL therapy

A cytokine named TRAIL binds to TRAIL receptors and kills cancer cells, but not normal cells. Therefore, various anticancer drugs targeting TRAIL receptors have been developed and gained great attention as a promising cancer therapeutics, but a certain population of cancer patients does not respond to the therapy.

15 Aug 2022