Induced Pluripotent Stem Cells News and Research

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Phase 1 trial examines safety and feasibility of stem cell treatment for Parkinson's

A recently launched Phase 1 clinical trial at Mass General Brigham is examining the safety and feasibility of a groundbreaking treatment approach for Parkinson's disease in which a patient's stem cells are reprogrammed to replace dopamine cells in the brain damaged by the disease.

6 Mar 2025

Researchers make breakthrough in understanding the role of tau protein in Alzheimer's

A research team at the University of Cologne has made a significant breakthrough in understanding the role of the tau protein in Alzheimer's disease.

28 Feb 2025

Gene editing shows promise for treating trisomy at cellular level

Gene editing techniques may eventually allow trisomy to be treated at the cellular level, according to an in vitro proof-of-concept study.

18 Feb 2025

Study reveals biotin’s potential to mitigate manganese-induced brain damage

While manganese is an essential mineral involved in many bodily functions, both deficiency and excessive exposure can cause health issues.

21 Jan 2025

CAR-NK cells offer safer, more accessible treatment for lymphoma

A new type of cell-based immunotherapy shows promise for B-cell lymphomas and - due to innovations in manufacturing - could make future cellular immunotherapies less expensive and more accessible to patients.

15 Jan 2025

Heart attack recovery enhanced by human stem cell spheroids, study shows

In a large-animal model study, researchers have found that heart attack recovery is aided by injection of heart muscle cell spheroids derived from human induced pluripotent stem cells, or hiPSCs, that overexpress cyclin D2 and are knocked out for human leukocyte antigen classes I and II.

7 Jan 2025

Microglial cells may hold key to Alzheimer's plaque removal

Immune cells in the brain called microglia can partially break down large amyloid plaques characteristic of Alzheimer's disease by latching on to them, forming a sort of external stomach and releasing digestive enzymes into the space, according to a preclinical study by Weill Cornell Medicine investigators.

23 Dec 2024

Why predictive retina models could be the future of IND applications

Discover how retina models are revolutionizing rare disease treatment and accelerating drug development.

From Newcells Biotech 22 Nov 2024

Uncovering the pathway behind ALS neurodegeneration

Approximately 5,000 people in the U.S. develop amyotrophic lateral sclerosis (ALS) each year. On average, they survive for only two to five years after being diagnosed, according to the Centers for Disease Control and Prevention.

8 Nov 2024

MD Anderson launches new institute for advancing cell therapy

The University of Texas MD Anderson Cancer Center today announced the launch of its Institute for Cell Therapy Discovery & Innovation, which will build upon longstanding MD Anderson clinical and research expertise to lead the world in developing and advancing impactful cell therapies for patients in need.

8 Nov 2024

Human midbrain organoids: A promising tool in the fight against Parkinson's disease

Advancements in organoid technology are crucial for Parkinson's disease research, providing human-relevant models for studying disease and testing therapies.

23 Oct 2024

Transformative tissue engineering research in space

An "out-of-this-world" project has the potential to transform the future of tissue engineering and liver transplantation through innovative research conducted aboard the International Space Station (ISS).

18 Oct 2024

USC's Keck School of Medicine partners with StemCardia to advance heart failure treatment

The Keck School of Medicine of USC has launched a strategic collaboration with StemCardia, a biotechnology company, founded by a Keck School of Medicine faculty member, that develops cellular and genetic therapies to address heart failure.

8 Oct 2024

Overcoming CRISPR's side effects for therapeutic applications

CRISPR is a revolutionary tool that allows scientists to precisely modify the genome and gene expression of cells in any organism. It's a reagent - a substance that facilitates a reaction - that combines an enzyme with a programmable RNA capable of locating specific genetic sequences. Once guided to the correct spot, the enzyme acts like a pair of scissors, cutting, replacing, or deleting sequences of DNA.

7 Oct 2024

Centenarians' stem cells unlock secrets to healthy aging

Individuals who display exceptional longevity provide evidence that humans can live longer, healthier lives.

25 Sep 2024

Space conditions disrupt rhythmic function of bioengineered heart tissues

Johns Hopkins Medicine scientists who arranged for 48 human bioengineered heart tissue samples to spend 30 days at the International Space Station report evidence that the low gravity conditions in space weakened the tissues and disrupted their normal rhythmic beats when compared to earth-bound samples from the same source.

23 Sep 2024

A promising new therapeutic target for MASLD identified

Using a novel stem cell platform, a team of the Medical University of South Carolina researchers has identified a pathway that could be targeted by drugs to reduce fat accumulation in patients with a common form of fatty liver disease known as metabolic dysfunction-associated steatotic liver disease, or MASLD.

11 Sep 2024

New target identified for potential ALS therapy

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that affects motor neurons.

10 Sep 2024

Breakthrough in blood stem cell development offers hope for leukemia and bone marrow failure

Melbourne researchers have made a world first breakthrough into creating blood stem cells that closely resemble those in the human body. And the discovery could soon lead to personalized treatments for children with leukemia and bone marrow failure disorders.

2 Sep 2024

Stem cell study identifies unique glial contributions to multiple sclerosis

A team of scientists from The New York Stem Cell Foundation (NYSCF) Research Institute and Case Western Reserve University has created the largest reported collection of stem cell models from multiple sclerosis (MS) patients and used them to identify unique ways in which glia – integral support cells in the brain – contribute to the disease.

26 Aug 2024