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Microbiome composition influences severity of Legionnaires' disease

Pneumonia is an infection of the lung alveoli caused by bacteria, viruses or fungi. It is one of the leading causes of morbidity and mortality worldwide, representing a clinical and economic burden and a global public health problem.

13 Sep 2023

New class of iron-targeting compounds found to hamper proliferation of cancer cells

Researchers at the University of Arizona Cancer Center discovered a new class of iron-targeting compounds that hamper the proliferation of cultured malignant cells in a laboratory setting.

12 Sep 2023

Unraveling the relationship between obesity-related metabolic dysfunction and endotrophin

With obesity rates projected to continue rising globally, there is an urgent need to understand the intricate mechanisms that contribute to metabolic diseases such as diabetes.

8 Sep 2023

Novavax's updated XBB.1.5 vaccine shows promising cross-neutralizing antibodies against new COVID-19 variants

The study reveals that Novavax's updated XBB.1.5 vaccine effectively induces cross-neutralizing antibodies against multiple Omicron XBB sub-variants in both mice and non-human primates.

5 Sep 2023

Can SARS-CoV-2 infect poultry?

New research in the Virology Journal suggests that chickens could become intermediate hosts for newly emerged SARS-CoV-2 variants, posing a potential threat to public health. The study identifies AXL and ACE2 receptors in chickens as likely binding sites for the virus, highlighting the need for further research and preventive measures.

5 Sep 2023

Innovate UK funding to support the development of powdered gene therapy for bone graft augmentation

TherageniX, a University of Nottingham spin out pioneering a dry powder gene therapy formulation for bone graft augmentation, and its collaborator, the University of Nottingham, have been awarded a £995,000 grant from Innovate UK, the UK’s innovation agency.

4 Sep 2023

Scientists discover new role for liver tPA in regulating cholesterol levels

Despite advances in treatment for high cholesterol, heart disease remains the leading cause of death in the U.S. Scientists at the Medical College of Wisconsin (MCW) are investigating the role of a form of cholesterol called very-low-density lipoprotein – and their findings may lead to new treatment options in the future.

1 Sep 2023

International consortium to study link between RSV infection and chronic respiratory tract diseases

UMC Utrecht will lead an international consortium that will try to answer a key question that's in the mind of many pediatricians, infectiologists, pulmonologists and other health professionals: "Why are children that had an RSV infection in early childhood at increased risk of developing asthma later in life?"

1 Sep 2023

TherageniX and University of Nottingham awarded £995K Innovate UK grant to develop powdered gene therapy for bone regeneration

Funding from Innovate UK’s Transforming Medicines Manufacturing program supporting innovative technologies for intracellular drug delivery.

1 Sep 2023

How diet and exercise may rewrite the Alzheimer's script at a molecular level

Researchers explore how lifestyle changes like diet and physical activity can influence microRNA expression in Alzheimer's patients, potentially offering new therapeutic avenues. The study fills a research gap in understanding how such lifestyle modifications could affect molecular mechanisms implicated in Alzheimer’s disease.

28 Aug 2023

The potential of targeting mitochondria-associated programmed cell death for age-related disease treatment

The review summarized the involvement of mitochondria in age-related disease progression and highlighted its potential as a therapeutic target of these diseases.

28 Aug 2023

Ciliopathies: A new understanding of the role of the NSL complex

The non-specific lethal (NSL) complex is a chromatin-associated factor that has been shown to regulate the expression of thousands of genes in both fruit flies and mammals.

25 Aug 2023

Small molecule inhibitor of the NLRP3 inflammasome for treating autoinflammatory diseases

Researchers described the preclinical profile of JT002, a novel and orally bioavailable small molecule inhibitor of the NLRP3 inflammasome.

24 Aug 2023

Texas Heart Institute receives $1.14 million grant to develop first-in-class drug to treat cardiovascular disease

The National Heart, Lung, and Blood Institute (NHLBI) recently awarded The Texas Heart Institute (THI) a two-year, $1.14 million grant to develop a novel, first-in-class drug to treat cardiovascular disease (CVD) as a significant improvement to current treatment regimens -; specifically for adverse events arising from atherosclerosis.

22 Aug 2023

Can air pollution shape adolescent brain development? New study reveals sex-specific effects of PM2.5, NO2, and O3 on white matter microstructure

Researchers investigated the sex-stratified effects of childhood exposure to ambient air pollutants.

22 Aug 2023

Scientists uncover new molecular targets for cardiovascular regulation

Scientists at City of Hope, one of the largest cancer research and treatment organizations in the United States and a leading research center for diabetes and other life-threatening illnesses, have uncovered new molecular targets on a cell receptor that play a major role in cardiovascular regulation.

14 Aug 2023

Intracellular News and Research

Microbiome composition influences severity of Legionnaires' disease

New class of iron-targeting compounds found to hamper proliferation of cancer cells

Unraveling the relationship between obesity-related metabolic dysfunction and endotrophin

Novavax's updated XBB.1.5 vaccine shows promising cross-neutralizing antibodies against new COVID-19 variants

Can SARS-CoV-2 infect poultry?

Innovate UK funding to support the development of powdered gene therapy for bone graft augmentation

Scientists discover new role for liver tPA in regulating cholesterol levels

International consortium to study link between RSV infection and chronic respiratory tract diseases

TherageniX and University of Nottingham awarded £995K Innovate UK grant to develop powdered gene therapy for bone regeneration

How diet and exercise may rewrite the Alzheimer's script at a molecular level

The potential of targeting mitochondria-associated programmed cell death for age-related disease treatment

Ciliopathies: A new understanding of the role of the NSL complex

Small molecule inhibitor of the NLRP3 inflammasome for treating autoinflammatory diseases

Texas Heart Institute receives $1.14 million grant to develop first-in-class drug to treat cardiovascular disease

Can air pollution shape adolescent brain development? New study reveals sex-specific effects of PM2.5, NO2, and O3 on white matter microstructure

Scientists uncover new molecular targets for cardiovascular regulation

Unveiling α1-AR secrets: breakthrough structures and targeted drug design

Synergistic winter flounder antimicrobial peptides unveil new path to enhanced bactericidal therapy

Newly identified protein plays a key role in the action of emerging anticancer therapies

Golgi apparatus may play a role in neuronal circuit reorganization during postnatal brain development

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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