Lipidomics News and Research

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Lipidomics refers to the study of cellular lipidomes, meaning the network of lipid constituents that maintain cellular and bodily health.

Bruker launches timsTOF fleX with ESI/MALDI capability for SpatialOMx at ASMS 2019

Bruker Daltonics has launched a novel timsTOF fleX mass spectrometer which combines ESI/MALDI capability for SpatialOMx on a single instrument.

From Bruker Daltonics 10 Jun 2019

HDL proteome behaves like a tiny Velcro ball that is rolling on surfaces

Cholesterol carried in high-density lipoprotein particles, or HDL cholesterol, has been dubbed the good cholesterol, because people whose HDL levels are high have a lower risk of developing heart disease. That link was first established in 1977 and has been confirmed over and over in epidemiological studies.

15 Feb 2019

Cell membrane complexes may be new target for drugs to kill cancer cells

Old molecules and new complexes: researchers at Hollings Cancer Center at the Medical University of South Carolina have discovered cell membrane complexes called ceramidosomes that may be a new target for drugs to kill cancer cells.

13 Feb 2019

New generation of chemists conducts research to further understand complex nature of lipids

The post-holiday New Year might not seem like an ideal time to celebrate fat. But when it comes to lipids, there is no better time.

11 Jan 2019

Scientists cast new light on function of long-mysterious PCSK9 mutation

High levels of low-density lipoproteins, parcels of lipids and protein that carry cholesterol, are a leading risk factor for heart disease. Many cholesterol medications lower LDL, some of them by targeting the protein PCSK9. In the January issue of the Journal of Lipid Research, scientists at the University of California, San Francisco, report on an investigation into why experiments on PCSK9 give different results in a test tube and in liver cells.

2 Jan 2019

Research suggests new approach to protect from common cold

As temperatures drop and the sniffles start, take hope; research published this summer suggests a new approach to protect ourselves from the common cold.

24 Oct 2018

Drug cocktail that increases lifespan discovered

A team of researchers led by Principal Investigator Dr Jan Gruber from Yale-NUS College has discovered a combination of pharmaceutical drugs that not only increases healthy lifespan in the microscopic worm Caenorhabditis elegans (C. elegans), but also delays the rate of ageing in them, a finding that could someday mean longer, healthier lives for humans.

22 Oct 2018

Seed oils are best choice for improving cholesterol

If you want to lower your low-density lipoprotein cholesterol, called LDL or, colloquially, "bad cholesterol," the research is clear about one thing: You should exchange saturated fats with unsaturated fat. If you want to know what you should use to sauté your dinner, that's a harder question to answer. Many of the studies establishing that mono- and polyunsaturated fats are better for blood lipids than saturated fats swapped out one food source at a time, making it hard to tell which of a plethora of vegetable oils might be most beneficial.

9 Oct 2018

New studies examine links between fatty liver disease and mitochondrial dysfunction

Researchers at Northeast Ohio Medical University studied the lifespan of mitochondrial proteins in a mouse model of fatty liver disease. Comparing the amount of protein between healthy mice and a mouse model of nonalcoholic fatty liver disease gave them an estimate of each protein's half-life.

17 Sep 2018

Study provides insight into link between sleep apnea and lipid metabolism

Obstructive sleep apnea is a clinical disorder characterized by repeated partial or complete blockage of the airway during sleep.

15 Aug 2018

Structure of a long-chain lipid that keeps our tears clear revealed

As anyone who has experienced an annoying alternation between dry and watery eyes can confirm, tears alone aren't enough to keep the eye from drying out. A microscopically thin film of oils known as the tear film lipid layer is key to preventing the tear film from evaporating.

9 Aug 2018

Researchers explore why heart failure and kidney disease correlate

People with chronic kidney disease are at unusually high risk of also developing cardiovascular disease; in fact, a patient with non-dialysis kidney disease is more likely to die of heart failure than to develop end-stage kidney failure.

24 Jul 2018

Extensive lipidomics studies reveal signatures of metabolic health and disease

Scientists from EPFL and the University of Wisconsin-Madison have carried out one of the most extensive lipidomics studies to date, connecting almost 150 different lipid species to their respective genetic regulators, revealing signatures of metabolic health and disease.

13 Jun 2018

Researchers take important step toward finding protein biomarkers during cancer surgery

Isabelle Fournier and her team are out to change surgical oncology. "Better surgery is associated with better prognosis and higher survival," said Fournier, a professor at the University of Lille and co-director of a proteomics center of INSERM, the French national institute of health.

24 May 2018

Researchers reveal how tumor cells disrupt circadian rhythm to survive

Tumor cells use the unfolded protein response to alter circadian rhythm, which contributes to more tumor growth, Hollings Cancer Center researchers at the Medical University of South Carolina find.

28 Dec 2017

Exosome isolation using ultracentrifugation

In the outpatient clinic and lab, our research studies aim to understand biological functions of exosomes and membrane particles.

From Beckman Coulter Life Sciences - Centrifugation 9 Feb 2017

Taking omega-3 supplements during pregnancy can reduce risk of childhood asthma by one third

Taking certain omega-3 fatty acid supplements during pregnancy can reduce the risk of childhood asthma by almost one third, according to a new study from the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC) and the University of Waterloo.

30 Dec 2016

Novel lipid-based therapeutic shows promise for combating drug resistance in AML

Researchers at the Medical University of South Carolina Hollings Cancer Center have discovered a mechanism that confers resistance to drugs used to treat certain types of acute myeloid leukemia (AML).

24 Oct 2016

MUSC Hollings Cancer Center receives $8.9 million grant to explore signaling in sphingolipids

The Medical University of South Carolina's Hollings Cancer Center received an $8.9 million grant from the National Cancer Institute designed to foster collaboration across clinical and laboratory research for the study of signaling in sphingolipids, a class of lipids known to be involved in the growth of solid tumor cancers.

10 May 2016

Understanding how individuals respond to aspirin

Researchers have learned new information about how different people respond to aspirin, a globally prescribed drug in cardioprotection. The research team, led by scientists at Cardiff University in the United Kingdom and including representatives from the University of Alabama at Birmingham and the University of Colorado, identified more than 5,600 lipids — or fats — in blood platelets and gained new insights into how these cells respond to aspirin.

29 Apr 2016