Lymph Nodes News and Research

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Stable nanoparticles train the immune system to fight cancer

Over the past decade, researchers have sought more effective and enduring cancer treatments. Among the wide variety of immunotherapies, Stimulator of Interfron Genes activation (STING agonism) has emerged as a particularly promising approach that harnesses a patient’s immune system to combat tumors throughout the body.

17 Jul 2023

Using a vaccine to boost the response of engineered T cells

Engineering T cells to destroy cancer cells has shown success in treating some types of cancer, such as leukemia and lymphoma. However, it hasn't worked as well for solid tumors.

5 Jul 2023

Are a high-refined carbohydrate diet and the alterations resulting from its intake linked to small intestine changes?

Researchers investigated whether a high-refined carbohydrate diet and associated metabolic alterations could cause small intestinal dysregulation.

27 Jun 2023

Unlocking HIV cure: Study highlights allogeneic immunity as key mechanism in eradicating latent virus reservoirs

Allogeneic stem cell transplantation with CCR5Δ32/Δ32 donors shows potential for HIV cure. Alloimmunity and CCR5 deficiency play significant roles in viral reservoir clearance.

19 Jun 2023

New research finds most women diagnosed with early breast cancer can expect to become long-term survivors

Researchers reported longitudinal outcomes among British women suffering from early invasive-type breast tumors as their initial tumor and those initially treated by surgical methods such as conservative surgery or mastectomy.

16 Jun 2023

Deep learning models could be crucial in battling the monkeypox virus

Researchers developed a machine-learning-based detection tool to detect mpox.

14 Jun 2023

Study findings could reassure most women treated for early breast cancer

Most women diagnosed with early stage breast cancer today can expect to become long term cancer survivors, finds a study published by The BMJ today.

13 Jun 2023

Study provides a new and promising strategy for future cancer immunotherapies

CD8+ T cells, a vital component of the immune system that provides immunity against cancer, have been the focal point of anti-cancer therapies.

13 Jun 2023

UVA discoveries highlight the different roles of blood vessels in solid tumors

Two new discoveries from the Dudley lab at UVA Cancer Center highlight the different roles of blood vessels in solid tumors – and the findings could help prevent breast cancer from spreading and enhance the effectiveness of one of the most important new cancer treatments in many years.

4 Jun 2023

Novel approach improves the efficacy of immune checkpoint blockade and minimizes related side effects

Scientists at Tohoku University have discovered a novel approach that improves the efficacy of immune checkpoint blockade (ICB) - a novel form of cancer treatment utilizing immune checkpoint inhibitors (ICIs) - and minimizes the associated side effects.

1 Jun 2023

Extended lymphadenectomy for locally advanced bladder cancer provides no patient benefit

An extended lymphadenectomy – removal of additional lymph nodes beyond the extent of the standard procedure – in patients undergoing radical cystectomy (removal of bladder and nearby tissues) because of clinically localized muscle-invasive bladder cancer provides no patient benefit as measured by disease-free survival or overall survival times.

30 May 2023

T-cell-inducing mRNA COVID-19 vaccine improves effectiveness

Researchers develop a lipid nanoparticle-formulated mRNA-based antigen encoding three SARS-CoV-2 peptides derived from non-structural proteins.

25 May 2023

Nonhuman primate study helps explain how stem cell transplantation can kill HIV virus

New animal research is helping explain why at least five people have become HIV-free after receiving a stem cell transplant.

25 May 2023

Wastewater surveillance reveals hidden scale of mpox rpidemic, challenging official figures

Research highlights the potential of wastewater-based epidemiology as a complementary tool to clinical monitoring for assessing the magnitude of a mpox epidemic. Findings suggest that the presence of mpox DNA in wastewater does not directly correspond to the number of hospitalizations, indicating the underestimation of the epidemic's scale and unidentified cases.

19 May 2023

Ticks found to harbor and release prions of chronic wasting disease

Researchers determined whether ticks contain transmission-relevant amounts of chronic wasting disease.

17 May 2023

Study aims to optimize radiotherapy treatment for patients with anal cancer

Reducing the dose and duration of radiotherapy treatments for anal cancer may result in fewer side effects, recent clinical trial results have shown.

15 May 2023

Novel arterivirus discovered in Amazonian rodents unveiling a potential viral spillover threat

Discovery of a novel arterivirus in Amazonian rodents sheds light on viral communities and raises concerns about potential transmission to humans.

14 May 2023

Combination treatment shows promise for aggressive subtype of non-Hodgkin lymphoma

Nearly 90 percent of patients with an aggressive subtype of non-Hodgkin lymphoma had their cancer go into remission in a small phase 2 clinical trial testing a treatment aimed at making chemotherapy more effective, according to Weill Cornell Medicine and NewYork-Presbyterian investigators.

5 May 2023

HIV status does not affect Tecovirimat treatment outcomes for Mpox virus infection

A retrospective cohort study comparing the clinical presentation and treatment outcomes of people with HIV and those without HIV who were treated with tecovirimat for confirmed mpox virus infection. The study found that HIV status did not seem to affect treatment outcomes.

4 May 2023

Testing hundreds of existing therapeutics to fight blood cancer more effectively

Multiple myeloma is a rare blood cancer caused by the uncontrolled multiplication of abnormal plasma cells.

27 Apr 2023