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Healthy lifestyles linked to specific metabolic markers, large study finds

Researchers identify metabolomic markers linked to healthy lifestyles in a large study, showing a connection between lipid metabolism and reduced mortality risks.

18 Feb 2024

Innovative immunotherapy targets rare melanoma subtypes

Scientists at the UCLA Health Jonsson Comprehensive Cancer Center have built and demonstrated the potential efficacy of a new chimeric antigen receptor (CAR) T-cell-based immunotherapy specifically designed to treat patients with cutaneous and rare subtypes of melanoma.

16 Feb 2024

Drug repurposing study finds lonafarnib effective against RSV

A study in Nature Communications identifies lonafarnib from the ReFRAME drug-repurposing library as a potent inhibitor of the RSV fusion protein, showing promise in reducing RSV infection in vitro and in vivo.

11 Feb 2024

Prenatal exposure to phthalates linked to higher risk of preterm birth and low birth weight

Research in The Lancet Planetary Health links prenatal phthalate exposure to increased risks of preterm birth and low birth weight, underscoring the need for regulatory oversight on chemicals used in consumer products.

11 Feb 2024

New treatment targeting aging cells could offer lasting relief for diabetic macular edema

Targeting senescent cells in the retina with a BCL-xL inhibitor shows promise as a durable treatment for diabetic macular edema, potentially offering long-term visual function improvements.

8 Feb 2024

Mitochondrial misfire sparks inflammation

Cells in the human body contain power-generating mitochondria, each with their own mtDNA-;a unique set of genetic instructions entirely separate from the cell's nuclear DNA that mitochondria use to create life-giving energy.

8 Feb 2024

Quest Pharm and Aston University develop world-first tablet to treat mouth ulcerations in chemotherapy patients

A Knowledge Transfer Partnership (KTP) between UK pharmaceutical company Quest Pharm and Aston University has developed a world-first tablet to treat the serious mouth ulcerations caused by high-dose chemotherapy.

7 Feb 2024

New cell therapy shows promise for critically ill COVID-19 patients with ARDS

Promising trial results indicate that a new type of cell therapy could improve the prognosis of those who are critically ill with acute respiratory distress syndrome (ARDS) resulting from severe Covid-19.

6 Feb 2024

SARS-CoV-2 fragments found to mimic immune system peptides, fueling inflammation

Study reveals SARS-CoV-2 fragments mimic immune peptides, potentially driving the virus's inflammatory response, offering insights into COVID-19's severe inflammation mechanisms.

5 Feb 2024

Scientists pinpoint two cell-surface proteins that partner to spur cancer cell growth

Scientists at City of Hope®, one of the largest cancer research and treatment organizations in the United States, have discovered a new cellular mechanism that plays an important role in cancer cells' ability to cause disease. The study was published in Nature Structural & Molecular Biology today.

5 Feb 2024

Simulations crack code of human egg fertilization

Who hasn't seen it before: the view through the microscope in which a sperm penetrates an egg cell and fertilizes it.

5 Feb 2024

First gene therapy trial aims to restore hearing in children

The aim of this clinical trial, which has just received approval in France, is to assess the safety and efficacy of a new gene therapy drug in children aged between 6 and 31 months with profound hearing loss.

5 Feb 2024

Unveiling HIV's "latch": New study reveals key to blocking infection

As the HIV virus glides up outside a human cell to dock and possibly inject its deadly cargo of genetic code, there's a spectacularly brief moment in which a tiny piece of its surface snaps open to begin the process of infection.

2 Feb 2024

Study sheds light on 7-DHC's potential to induce cell death-resistant state in tumors

Cell death is fundamental to life and, thus, healthy aging. In the realm of cellular biology, ferroptosis (a form of programmed cell death) has emerged not only as a focal point of research for its potential in eliminating cancer cells, but also its role in a plethora of other diseases, including neurodegenerative diseases such as Alzheimer's disease, eye diseases such as Retinitis pigmentosa and age-related macular degeneration, as well as ischemia, cardiovascular disease, liver disease, acute kidney injury and inflammation.

1 Feb 2024

CRISPR revolutionized: New method edits genes directly in the body

Most approved gene therapies today, including those involving CRISPR-Cas9, work their magic on cells removed from the body, after which the edited cells are returned to the patient.

1 Feb 2024

Immune protein Ku70 key in fighting bowel cancer

Study establishes Ku70's role in tumor suppression, showing that reduced expression or mutations in this DNA repair protein significantly increase intestinal cancer risk.

30 Jan 2024

Tomato juice can get rid of enteric bacteria that can harm people's health

Tomato juice can kill Salmonella Typhi and other bacteria that can harm people's digestive and urinary tract health, according to research published this week in Microbiology Spectrum, a journal of the American Society for Microbiology. Salmonella Typhi is a deadly human-specific pathogen that causes typhoid fever.

30 Jan 2024