Immune System News and Research

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Understanding age-related changes in T cells and vaccine response

As flu season approaches and public health officials roll out their annual push for vaccination, Allen Institute scientists are learning why vaccines can trigger a weaker response in older adults, around age 65, and what can be done to improve them.

29 Oct 2025

Experimental compound reduces cell death, inflammation, and organ damage in diabetes

An experimental compound reduced the cell death, inflammation, and organ damage seen with diabetes.

29 Oct 2025

Two analgesic drugs may one day be repurposed as anti-tumor therapies

Peripheral afferent neurons - nerves that send signals from all areas of the body to the central nervous system (brain and spinal cord) - are known to infiltrate and grow within malignant bone tumors called osteosarcomas, often accompanied by severe pain.

29 Oct 2025

Some acute and chronic viral infections linked to increased risk of cardiovascular disease

In the weeks following a bout of influenza or COVID, the risk of heart attack or stroke may rise dramatically, and chronic infections such as HIV may increase the long-term risk of serious cardiovascular disease events, according to new, independent research published today in the Journal of the American Heart Association, an open access, peer-reviewed journal of the American Heart Association.

29 Oct 2025

Exploring the gut-brain-immune axis in neurodegeneration

Neurodegenerative diseases (NDs), such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS), represent a growing global health burden, particularly in aging populations.

28 Oct 2025

Hypoxia weakens the body's infection defense by changing genetic material of neutrophils

Low oxygen levels in the blood can alter the genetic makeup of key immune cells, weakening the body's ability to fight infection, new research shows.

28 Oct 2025

$Reducing femoral fractures in total hip replacement with safer implant designs$

Reducing femoral fractures in total hip replacement with safer implant designs

As populations continue to age, total hip replacement (THR) is becoming an increasingly common surgical procedure.

28 Oct 2025

Study finds high levels of ultrashort-chain PFAS in blood samples of Wilmington residents

In a new study, researchers found high levels of ultrashort-chain per- and polyfluoroalkyl substances (PFAS) in blood samples taken from Wilmington, N.C. residents between 2010-2016.

27 Oct 2025

Study reveals how eosinophils play a protective role against Candida infections

New research shows that eosinophils, immune cells usually linked to allergies, also play a protective role against Candida infections by using the CD48 receptor to recognize the fungus and release proteins that stop its growth.

27 Oct 2025

Genetic analysis of blood sample could offer a non-invasive way for early Parkinson’s diagnosis

The genetic analysis of a blood sample could become a tool for the early diagnosis of Parkinson's disease, according to an exploratory study led by researchers from the Miguel Hernández University of Elche (UMH).

27 Oct 2025

Mitochondria and lysosomes work together to control regulatory T cell activation

Metabolism guides the activation states of regulatory T cells, the immune cells that prevent inappropriate activation of the immune system.

24 Oct 2025

First multiple sclerosis patient in the UK receives CAR T cell therapy in groundbreaking trial

A multiple sclerosis (MS) patient in the UK was the first to receive CAR T cell therapy, invented by UCL researchers, in a clinical trial testing whether this personalized treatment can slow or even halt the progression of the disease.

24 Oct 2025

Researchers map the complex sugar chains attached to rat serum proteins

A comprehensive study mapped the dynamic glycosylation landscape of rat serum proteins, uncovering sex- and time-dependent variations with clear cell-type specificity.

24 Oct 2025

How COVID mRNA vaccines may make cancer treatments more effective

Researchers found that COVID-19 mRNA vaccines, when given within 100 days of starting immune checkpoint inhibitors, were linked to significantly longer survival in lung and melanoma cancer patients. The vaccines trigger a powerful type-I interferon response that primes tumors to become more responsive to immunotherapy.

23 Oct 2025

Antibody discovery could provide new treatment options for aggressive breast cancers

A new potential antibody therapy strategy which restricts the growth of treatment-resistant breast cancers has been developed by scientists.

23 Oct 2025

Psoriasis-linked gene mutation may also play a surprising role in gut health

A mutation previously linked to skin disorders like psoriasis may also play a surprising role in gut health, according to new research published by scientists at VIB-UGent and colleagues from UGent, the University of Barcelona, and University College London.

23 Oct 2025

Disruption of glial circadian rhythms linked to Alzheimer's disease progression

Alzheimer's disease is notorious for scrambling patients' daily rhythms. Restless nights with little sleep and increased napping during the day are early indicators of disease onset, while sundowning, or confusion later in the day, is typical for later stages of the disease.

23 Oct 2025

New type of immunotherapy could change the treatment plan for triple-negative breast cancer

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Immune System News and Research

Understanding age-related changes in T cells and vaccine response

Experimental compound reduces cell death, inflammation, and organ damage in diabetes

Two analgesic drugs may one day be repurposed as anti-tumor therapies

Some acute and chronic viral infections linked to increased risk of cardiovascular disease

Exploring the gut-brain-immune axis in neurodegeneration

Hypoxia weakens the body's infection defense by changing genetic material of neutrophils

Reducing femoral fractures in total hip replacement with safer implant designs

Study finds high levels of ultrashort-chain PFAS in blood samples of Wilmington residents

Study reveals how eosinophils play a protective role against Candida infections

Genetic analysis of blood sample could offer a non-invasive way for early Parkinson’s diagnosis

Mitochondria and lysosomes work together to control regulatory T cell activation

First multiple sclerosis patient in the UK receives CAR T cell therapy in groundbreaking trial

Researchers map the complex sugar chains attached to rat serum proteins

How COVID mRNA vaccines may make cancer treatments more effective

Antibody discovery could provide new treatment options for aggressive breast cancers

Psoriasis-linked gene mutation may also play a surprising role in gut health

Disruption of glial circadian rhythms linked to Alzheimer's disease progression

New type of immunotherapy could change the treatment plan for triple-negative breast cancer

New study solves lung transplant rejection mystery

Pathogenic bacteria can block gut’s natural defense to spread infection

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