Proliferation News and Research

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Bergamot fiber shows promise in battling neurodegenerative disorders

Bergamot fiber (BF), a byproduct of citrus fruit processing, shows antioxidant properties and protects against neurotoxicity induced by amyloid beta protein (Aβ), suggesting potential benefits for Alzheimer's disease treatment and waste reduction.

13 Jun 2023

Regulatory connection between DREAM and cellular senescence may play a potential role in aging process

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 10, entitled, "Key elements of cellular senescence involve transcriptional repression of mitotic and DNA repair genes through the p53-p16/RB-E2F-DREAM complex."

13 Jun 2023

DYRK1A gene may dictate susceptibility to multiple highly pathogenic coronaviruses

Entry of the SARS-CoV-2 virus into human tissues depends on the activity of a host gene that regulates production of a key viral receptor, according to a study publishing June 13th in the open access journal PLOS Biology by Madison Strine and Craig Wilen of Yale University, US, and colleagues.

13 Jun 2023

Breaking barriers: hydrogel reservoir unleashes the potential of HSV-1 virotherapy in cancer

Researchers evaluated the therapeutic efficacy of Navoximod.

13 Jun 2023

The battle against avian influenza: genetic analysis unveils the origins of H5N1 outbreak

Researchers analyzed epidemiologic and phylogeographic characteristics of the avian influenza virus.

13 Jun 2023

Oliver Dowden: New Biothreats Radar will be key to the UK’s fight against future biological threats

A new Biothreats Radar capable of scanning biological risks that pose a threat to the public will be key to the UK's fight and preparation for future pandemics, the Deputy Prime Minister Oliver Dowden has announced today (Monday 12 June).

12 Jun 2023

Revolution in neuroscience: 2D nanomaterials propel advances in brain repair, treatment, and diagnosis

Review discusses the increasing importance of two-dimensional nanomaterials like graphene in neuroscience, highlighting their potential in nerve repair, creating brain-mimicking synaptic devices, and treating neurological disorders. It also considers the challenges and future prospects of these materials in this complex field.

11 Jun 2023

Using Src N-terminal regulatory element as potential oncotarget

A new research perspective was published in Oncotarget's Volume 14 on May 19, 2023, entitled, "Targeting the Src N-terminal regulatory element in cancer."

9 Jun 2023

PREACH-M trial: Lenzilumab may improve treatment response in chronic myelomonocytic leukemia

Humanigen, Inc.today extended previously reported results by presenting additional, statistically significant hematologic improvements and reductions in inflammatory markers from lenzilumab, its investigational drug, in a Phase 2/3 trial of treatment-naïve participants with chronic myelomonocytic leukemia and RAS-pathway mutations.

9 Jun 2023

Study identifies a promising target for development of vaccine against spotted fever

A protein found in cells of the hard tick Amblyomma sculptum, the main vector of the bacterium that causes Brazilian spotted fever (also known as Rocky Mountain spotted fever), is essential to the tick's survival while feeding, making it a promising target for development of a vaccine, according to an article published in the journal Parasites & Vectors.

7 Jun 2023

Study reveals intricate pathway that dictates the cell’s ability to be resilient and plastic

Researchers have long thought that once a cell starts down its path of differentiation, growing into a skin cell or a liver cell or a neuron, that path could not be changed.

7 Jun 2023

Research opens door to new, more efficient drug combinations for acute myeloid leukemia

Acute myeloid leukemia (AML) is a very aggressive disease in which cells proliferate abnormally, invading the bone marrow and interfering with normal blood cell production. It is the most common acute leukemia in adults with the worst prognosis.

5 Jun 2023

Study shows efficacy and safety of novel FolRα-targeting antibody drug conjugate in recurrent epithelial ovarian cancer

Updated dose expansion data of the phase I STRO-002-GM1 study have been presented today by Ana Oaknin, Principal Investigator of the Vall d'Hebron Institute of Oncology's (VHIO) Gynecological Malignancies Group, on the ground at the 2023 Annual Meeting of the American Society of Clinical Oncology (ASCO), 2-6 June in Chicago, USA.

4 Jun 2023

Multiple sclerosis: Immune cell invasion enabled by blood-brain barrier breakdown

Blood-brain barrier breakdown in multiple sclerosis leads to immune cell infiltration into the central nervous system. Antigen presentation at the barrier promotes CD8+ T cell entry, triggering focal breakdown and hindering their invasion.

4 Jun 2023

Researchers characterize a unique molecular mechanism of early stages of programmed cell death

Researchers have for the first time characterized a unique molecular mechanism of the early stages of programmed cell death or apoptosis, a process which plays a crucial role in prevention of cancer.

2 Jun 2023

Exposure to Agent Orange associated with increased risk of myeloproliferative neoplasms in veterans

Research conducted at Georgetown University's Lombardi Comprehensive Cancer Center and the Washington DC VA Medical Center on a database of veterans exposed to Agent Orange found an association for an increased risk of developing myeloproliferative neoplasms (MPNs), which are acquired stem cell disorders that can lead to overproduction of mature blood cells complicated by an increased risk of blood clots in arteries and veins.

2 Jun 2023

MFAP5, a microfibril-associated protein, unveiled as key player in scar formation and wound healing

MFAP5, a microfibril-associated protein, plays a significant role in wound healing by regulating fibroblast function, collagen deposition, and angiogenesis, suggesting its potential as a modulator of scar formation.

1 Jun 2023

Study suggests licorice-derived liquiritigenin has breast cancer prevention potential for high-risk postmenopausal women

Researchers evaluated the potential of three licorice (Glycyrrhiza) species, i.e., G. glabra (GG), G. uralensis (GU), and G. infata (GI), and hops (Humulus lupulus), and their main bioactive polyphenols, to prevent breast malignancy.

1 Jun 2023

The National Environmental Assessment Reporting System: reporting foodborne illness outbreaks at retail food establishments during 2017–2019

Researchers summarized environmental health data collected by the United States (U.S.) state and local health departments.

1 Jun 2023

The immunopathology of post-acute sequelae of SARS-CoV-2 infection: highlighting the knowledge gaps

The immunopathology of post-acute sequelae of SARS-CoV-2 infection (PASC).

31 May 2023

Proliferation News and Research

Bergamot fiber shows promise in battling neurodegenerative disorders

Regulatory connection between DREAM and cellular senescence may play a potential role in aging process

DYRK1A gene may dictate susceptibility to multiple highly pathogenic coronaviruses

Breaking barriers: hydrogel reservoir unleashes the potential of HSV-1 virotherapy in cancer

The battle against avian influenza: genetic analysis unveils the origins of H5N1 outbreak

Oliver Dowden: New Biothreats Radar will be key to the UK’s fight against future biological threats

Revolution in neuroscience: 2D nanomaterials propel advances in brain repair, treatment, and diagnosis

Using Src N-terminal regulatory element as potential oncotarget

PREACH-M trial: Lenzilumab may improve treatment response in chronic myelomonocytic leukemia

Study identifies a promising target for development of vaccine against spotted fever

Study reveals intricate pathway that dictates the cell’s ability to be resilient and plastic

Research opens door to new, more efficient drug combinations for acute myeloid leukemia

Study shows efficacy and safety of novel FolRα-targeting antibody drug conjugate in recurrent epithelial ovarian cancer

Multiple sclerosis: Immune cell invasion enabled by blood-brain barrier breakdown

Researchers characterize a unique molecular mechanism of early stages of programmed cell death

Exposure to Agent Orange associated with increased risk of myeloproliferative neoplasms in veterans

MFAP5, a microfibril-associated protein, unveiled as key player in scar formation and wound healing

Study suggests licorice-derived liquiritigenin has breast cancer prevention potential for high-risk postmenopausal women

The National Environmental Assessment Reporting System: reporting foodborne illness outbreaks at retail food establishments during 2017–2019

The immunopathology of post-acute sequelae of SARS-CoV-2 infection: highlighting the knowledge gaps

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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