Clinical Trial News and Research

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COST Actions drive innovation in cancer research across Europe

Cancer is a major challenge in the modern world, affecting millions of people across Europe. The prevalence of this disease requires the development of innovative and complementary treatment approaches.

19 Sep 2025

Oral drug baricitinib shows promise in slowing early type 1 diabetes progression

In 2023, the groundbreaking Australian BANDIT (Baricitinib in New Onset Type 1 Diabetes) trial [1] reported that a daily pill of baricitinib, commonly prescribed for rheumatoid arthritis and alopecia, could safely preserve the body's own insulin production and slow the progression of type 1 diabetes (T1D) in people recently diagnosed with the condition.

19 Sep 2025

AGA releases new clinical guideline for diagnosing and managing gastroparesis

The American Gastroenterological Association (AGA) has released a new clinical guideline with 12 conditional recommendations for diagnosing and managing gastroparesis, a serious and often debilitating disease.

19 Sep 2025

New research aims to use eyedrops to lower lifetime risk of nearsightedness complications

For the first time, researchers are leading a national study to see if the onset of nearsightedness can be delayed – and consequently reduced in magnitude over a lifetime – with the use of eyedrops in young children.

19 Sep 2025

Oral GLP-1 drug orforglipron achieves significant weight loss in global trial

Patients taking an experimental oral GLP-1 drug lost significant weight and improved their heart and metabolic risk factors in a large, international, phase III clinical trial led by investigators at Weill Cornell Medicine, McMaster University, York University and other institutions

18 Sep 2025

Study reveals early nicotinamide use reduces risk of aggressive skin cancers

A large U.S. Department of Veterans Affairs cohort study found that Nicotinamide use was associated with a 14% lower risk of new keratinocyte skin cancers, driven by a 22% reduction in cSCC and no reduction in BCC. The strongest benefit (56% lower risk) appeared when nicotinamide was started after a patient’s first skin cancer, with diminishing returns after multiple cancers.

18 Sep 2025

Nursing researchers explore new ways to improve the quality of methadone treatment

Researchers at the University of Arizona College of Nursing are testing an intervention to reduce staff stress and improve methadone patient treatment retention for opioid use disorder thanks to a $4.5 million grant from the National Institute on Drug Abuse, a division of the National Institutes of Health.

18 Sep 2025

Clinical trial reveals encouraging results for apitegromab in spinal muscular atrophy

A new clinical trial has revealed encouraging results for a muscle-targeting therapy aimed at improving motor function in children and adolescents with spinal muscular atrophy, according to a study published in The Lancet Neurology.

18 Sep 2025

Investigational drug reduces hot flashes and night sweats for post-menopausal women

The investigational drug elinzanetant significantly reduces hot flashes and night sweats for post-menopausal women, a large, international clinical trial has found.

18 Sep 2025

University of Houston co-leads national study on atropine eyedrops for nearsightedness prevention

The University of Houston is co-leading a national study, the first of its kind in the United States, exploring whether atropine eyedrops can delay the onset of nearsightedness in young children and lessen its progression over a lifetime, a project with potential to shape future standards in vision care.

18 Sep 2025

New molecule offers a more targeted and potent immunotherapy

A newly developed molecule brings together two powerful immunotherapy strategies in one treatment. Researchers at the University of Basel and University Hospital Basel, Switzerland, have demonstrated that this fusion protein can both block the "do not attack" signal used by cancer cells and selectively activate tumor-fighting immune cells. This dual action could pave the way for more effective cancer therapies with fewer side effects.

18 Sep 2025

Scientists unveil new obesity drug that reprograms fat and energy use

Details of a new drug that aims to treat the underlying causes of obesity are being presented at the annual meeting of the European Association for the Study of Diabetes (EASD) in Vienna, Austria (15-19 September).

18 Sep 2025

Implantable device helps stabilize blood pressure in spinal cord injury patients

Getting out of bed in the morning without the risk of passing out is a game-changer for 32-year-old Cody Krebs.

17 Sep 2025

Low dose of aspirin cuts recurrence risk in colorectal cancer with genetic mutation

A Swedish-led research team at Karolinska Institutet and Karolinska University Hospital has shown in a new randomized clinical trial that a low dose of the well-known medicine aspirin halves the risk of recurrence after surgery in patients with colon and rectal cancer with a certain type of genetic alteration in the tumor.

17 Sep 2025

Tai chi improves memory and sleep in older adults with type 2 diabetes

A 12-week randomized trial found that remotely delivered Tai Chi significantly enhanced cognitive performance and sleep quality in older adults with Type 2 Diabetes. These gains surpassed those from supervised fitness walking or usual care, without increasing adverse events.

17 Sep 2025

Cocoa extract supplements linked to reduced inflammation in older adults

Could cocoa extract supplements rich in cocoa flavanols reduce inflammation and, in turn, prevent age-related chronic diseases? In a new study from the COcoa Supplement and Multivitamin Outcomes Study (COSMOS), investigators from Mass General Brigham and their colleagues looked at changes in five age-related markers of inflammation among participants who received daily cocoa supplements over several years.

17 Sep 2025

Can changing food texture reduce how much we eat? Dutch study investigates

A new randomized controlled trial protocol from the Netherlands will test whether altering the texture, and thus the eating rate, of ultra-processed foods can reduce daily energy intake. The study will investigate how sensory properties, such as food hardness, affect metabolism, appetite, and microbiome composition.

16 Sep 2025

Stem cell therapy restores brain function after stroke

Stem cell transplantation can reverse stroke damage, researchers at the University of Zurich report. Its beneficial effects include regeneration of neurons and restoration of motor functions, marking a milestone in the treatment of brain disorders.

16 Sep 2025

Survey shows high levels of mental health difficulties among young adults

The majority (64%) of young adults in Britain say they have experienced mental health difficulties, with a third (32%) expecting to need support in the coming year, according to polling commissioned from YouGov by UCL's Grand Challenge of Mental Health & Wellbeing.

16 Sep 2025

Foods taste sweeter or saltier than before for some people taking Ozempic, Wegovy or Mounjaro

New research being presented at the Annual Meeting of the European Association for the Study of Diabetes (EASD) in Vienna, Austria (15-19 September) shows that some individuals who are taking Ozempic, Wegovy or Mounjaro find that foods taste sweeter or saltier than before.

16 Sep 2025

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Clinical Trial News and Research

COST Actions drive innovation in cancer research across Europe

Oral drug baricitinib shows promise in slowing early type 1 diabetes progression

AGA releases new clinical guideline for diagnosing and managing gastroparesis

New research aims to use eyedrops to lower lifetime risk of nearsightedness complications

Oral GLP-1 drug orforglipron achieves significant weight loss in global trial

Study reveals early nicotinamide use reduces risk of aggressive skin cancers

Nursing researchers explore new ways to improve the quality of methadone treatment

Clinical trial reveals encouraging results for apitegromab in spinal muscular atrophy

Investigational drug reduces hot flashes and night sweats for post-menopausal women

University of Houston co-leads national study on atropine eyedrops for nearsightedness prevention

New molecule offers a more targeted and potent immunotherapy

Scientists unveil new obesity drug that reprograms fat and energy use

Implantable device helps stabilize blood pressure in spinal cord injury patients

Low dose of aspirin cuts recurrence risk in colorectal cancer with genetic mutation

Tai chi improves memory and sleep in older adults with type 2 diabetes

Cocoa extract supplements linked to reduced inflammation in older adults

Can changing food texture reduce how much we eat? Dutch study investigates

Stem cell therapy restores brain function after stroke

Survey shows high levels of mental health difficulties among young adults

Foods taste sweeter or saltier than before for some people taking Ozempic, Wegovy or Mounjaro

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