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Once-daily oral treatment shows positive results in first human study for obesity treatment

A first-in-human study of an investigational once-daily oral treatment for obesity (SYNT-101) demonstrated positive preliminary data for the safe and effective redirection of nutrient absorption into the lower intestine, the weight loss and metabolic management mechanism behind gastric bypass surgery.

14 May 2025

Readers scrutinize federal cuts and medical debt

The recent KFF Health News article "Beyond Ivy League, RFK Jr.'s NIH Slashed Science Funding Across States That Backed Trump" (April 17) struck a nerve.

13 May 2025

Hormone FGF21 reverses fatty liver disease by signaling the brain

A pioneering research study published today in Cell Metabolism details how the hormone FGF21 (fibroblast growth factor 21) can reverse the effects of fatty liver disease in mice. The hormone works primarily by signaling the brain to improve liver function.

13 May 2025

BSO drug mimics anti-obesity effects of difficult sulfur amino acid restricted diet

A new research paper was published in Aging (Aging-US) Volume 17, Issue 4, on April 7, 2025, titled "Pharmacological recapitulation of the lean phenotype induced by the lifespan-extending sulfur amino acid-restricted diet."

13 May 2025

Pentoxifylline offers no survival benefit for severe alcohol-associated hepatitis

Severe alcohol-associated hepatitis (sAH) remains a highly lethal condition with limited therapeutic options. Characterized by rapid liver decompensation, sAH is often accompanied by acute kidney injury (AKI), a complication that substantially worsens prognosis.

13 May 2025

New study identifies wedelolactone as a potent topical treatment for psoriasis

Announcing a new publication for Acta Materia Medica journal. Psoriasis is a chronic inflammatory disorder for which phosphodiesterase-4 (PDE4) inhibitors have emerged as promising therapeutic agents due to an ability to regulate inflammatory signaling pathways.

13 May 2025

Multiple health conditions linked to higher depression risk

People with multiple long-term physical health conditions are at a significantly greater risk of developing depression, a study shows.

13 May 2025

Collagen protein bars show promise for safe and effective weight loss

Research being presented at this year's European Congress on Obesity (ECO 2025) and published in the journal Nutrients indicates that collagen could be a safe and effective weight-loss supplement.

12 May 2025

Lipid buildup predicts weaker bones once it passes a critical threshold

A large cross-sectional study using NHANES data found a non-linear negative relationship between lipid accumulation product (LAP) and lumbar spine bone mineral density (BMD). The association became significant only above a threshold value (ln-LAP > 2.846), independent of BMI.

12 May 2025

HER3 reemerges as a key driver of cancer progression and therapy resistance

A new publication shines a spotlight on HER3, a long-overlooked member of the ErbB receptor family, revealing its critical role in cancer progression and resistance to therapy.

12 May 2025

Researchers uncover how Entamoeba histolytica evades the immune system

The single-celled parasite Entamoeba histolytica infects 50 million people each year, killing nearly 70,000. Usually, this wily, shape-shifting amoeba causes nothing worse than diarrhea.

12 May 2025

GLP-1RAs show added protection against cancer beyond weight reduction

New research being presented at this year's European Congress on Obesity (ECO) in Malaga, Spain (11-14 May) and published in the journal eClinicalMedicine finds that first generation weight-loss medications like liraglutide and exenatide appear to show anti-cancer benefits beyond weight loss.

11 May 2025

Early menopause increases risk of fatty liver disease and metabolic disorders

Women who experience menopause before the age of 50 - and especially before the age of 45 - are more likely to develop fatty liver disease and its related metabolic risk factors within one year after menopause, according to research presented at the first Joint Congress between the European Society of Paediatric Endocrinology (ESPE) and the European Society of Endocrinology (ESE).

11 May 2025

Gum disease bacterium linked to increased risk of atrial fibrillation

Tempted to skip the floss? Your heart might thank you if you don't. A new study from Hiroshima University (HU) finds that the gum disease bacterium Porphyromonas gingivalis (P. gingivalis) can slip into the bloodstream and infiltrate the heart.

10 May 2025

Study reveals colonic inflammation as the trigger for beta cell growth in obesity

Researchers at the Tohoku University Graduate School of Medicine have uncovered a key primary step in the hepatic ERK pathway that leads to increased insulin production.

9 May 2025

Liver disease in pregnancy linked to higher risk of preterm birth

Pregnant women with metabolic dysfunction-associated steatotic liver disease (MASLD) have an increased risk of giving birth prematurely and the risk increase cannot be explained by obesity, according to a new study from Karolinska Institutet published in the journal eClinicalMedicine.

9 May 2025

Annual blood test could detect cancer earlier and save lives

A single blood test, designed to pick up chemical signals indicative of the presence of many different types of cancer, could potentially thwart progression to advanced disease while the malignancy is still at an early stage and amenable to treatment in up to half of cases, suggests a modelling study published in the open access journal BMJ Open.

8 May 2025

Mature liver cells trigger regeneration in response to neighboring injury

Acetaminophen is the most frequently taken fever and pain medication worldwide, but overdosing can be toxic to liver cells. In the United States, about 1,600 cases of acute liver failure and 500 deaths occur each year due to acetaminophen overuse and liver failure.

8 May 2025

Obicetrapib slashes LDL cholesterol by over 30% in high-risk heart patients

A large multinational trial published in the New England Journal of Medicine shows that obicetrapib significantly lowers LDL cholesterol in high-risk cardiovascular patients. The CETP inhibitor also improved key lipid parameters with no major safety concerns, supporting its role in future combination therapies.

8 May 2025

Macrophages take center stage in liver healing after injury

The liver is famous for its remarkable ability to regenerate, but that healing power depends heavily on the actions of its resident immune cells. A new study spotlights macrophages, the liver's cleanup and repair specialists, revealing that these cells quickly adapt after injury to clear debris and support tissue recovery.

7 May 2025