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First successful quantification of membrane lipids in a living cell

Could controlling cell-membrane fat play a key role in turning off disease? Researchers at the University of Illinois at Chicago think so, and a biosensor they've created that measures membrane lipid levels may open up new pathways to disease treatment.

10 Oct 2011

MicroRNA-101 can block autophagy in cancer cells

All cells in our body have a system that can handle cellular waste and release building blocks for recycling. The underlying mechanism is called autophagy and literally means "self-eating". Many cancer cells have increased the activity of this system and the increased release of building blocks equip the cancer cells with a growth advantage and can render them resistant towards treatment.

10 Oct 2011

Researchers identify cellular pathway to potentially block disease-inducing inflammation

Researchers have discovered a cellular pathway that promotes inflammation in diseases like asthma, rheumatoid arthritis, psoriasis, inflammatory bowel disease, and multiple sclerosis. Understanding the details of this pathway may provide opportunities for tailored treatments of inflammatory and autoimmune diseases.

10 Oct 2011

Researchers show how nuclear receptors battle each other during fruit fly metamorphosis

Growing up just got more complicated. Thomas Jefferson University biochemistry researchers have shown for the first time that the receptor for a major insect molting hormone doesn't activate and repress genes as once thought. In fact, it only activates genes, and it is out-competed by a heme-binding receptor to repress the same genes during the larval to pupal transition in the fruit fly.

7 Oct 2011

NCKU research team discovers potential target to treat osteoporosis

A National Cheng Kung University (NCKU) research team has discovered that a protein called interleukin (IL)-20 is a key to treating osteoporosis, a disease that lowers a person's bone density.

7 Oct 2011

Scientists discover rare genetic alteration responsible for hypoglycaemia

Cambridge scientists have identified the cause of a rare, life-threatening form of hypoglycaemia. Their findings, which have the potential to lead to pharmaceutical treatments for the disorder, were published today, 07 October, in the journal Science.

7 Oct 2011

Scientists discover new metabolic pathway which makes gliomas more aggressive

A research alliance of Heidelberg University Hospital and the German Cancer Research Center, jointly with colleagues of the Helmholtz Center for Environmental Research in Leipzig, have discovered a new metabolic pathway which makes malignant brain tumors (gliomas) more aggressive and weakens patients' immune systems.

7 Oct 2011

Scientists discover how cells detect tissue damage and modify their repair properties

Scientists have discovered how cells detect tissue damage and modify their repair properties accordingly. The findings, published in the journal Developmental Cell, could open up new opportunities for improving tissue repair in patients following illness or surgery.

7 Oct 2011

Virus DNA uncoated with aid of host cell

They have been around since the dawn of time and are a model of evolutionary success: viruses. Viruses are extremely adaptable but they have a problem: They cannot reproduce, so they smuggle their genes into suitable host cells. In the case of some viruses, the viral DNA has to enter the cell nucleus to reproduce. This has been known for almost 50 years.

4 Oct 2011

Lipomannan on TB bacterium's outer cell surface can block TNF production

The bacterium that causes tuberculosis has a unique molecule on its outer cell surface that blocks a key part of the body's defense. New research suggests this represents a novel mechanism in the microbe's evolving efforts to remain hidden from the human immune system.

4 Oct 2011

Researchers identify specific molecule that alters how breast cancer cells move

Researchers from the University of Michigan Comprehensive Cancer Center have identified a specific molecule that alters how breast cancer cells move. This affects the cells' ability to spread or metastasize to distant parts of the body, the hallmark of deadly, aggressive cancer.

4 Oct 2011

Researchers identify new enzyme function that may protect against anemia

Researchers at St. Michael's Hospital have discovered a new function for an enzyme that may protect against organ injury and death from anemia.

4 Oct 2011

La Jolla Institute scientist identifies previously unknown T cell interaction

Most of the time, the immune system is the body's protector, warding off invading viruses and bacteria before they can lead to infection and disease. But in autoimmune diseases, the immune system does an about face, turning on the body and attacking normal cells.

3 Oct 2011

ViroPharma licenses worldwide rights from Intellect Neurosciences to OX1 for treatment of FA

ViroPharma Incorporated today announced the license of worldwide rights from Intellect Neurosciences, Inc. to its clinical stage drug candidate, OX1, being developed for the treatment of Friedreich's Ataxia (FA), a rare, hereditary, progressive neurodegenerative disease.

1 Oct 2011

Study demonstrates how the intestine maintains 'immune tolerance' under healthy conditions

Imagine a single drug that would treat most, if not all, autoimmune disorders, such as asthma, inflammatory bowel disease, and Lupus. That might not be so hard to do thanks to a team of researchers who have discovered a molecule normally used by the body to prevent unnecessary immune reactions.

30 Sep 2011

New targeting approach to develop an active site-directed, drug-like PTP1B inhibitor

The work of a team of scientists at Cold Spring Harbor Laboratory (CSHL) led by Professor Nicholas Tonks FRS, suggests a way to overcome one of the major technical obstacles preventing a leading therapeutic target for diabetes and obesity from being addressed successfully by novel drugs.

30 Sep 2011

Fat-rich 'western diet' fuels cardiovascular disease, type 2 diabetes and obesity

A major risk factor for cardiovascular disease, type 2 diabetes and other health- and life-threatening conditions, obesity is epidemic in the United States and other developed nations where it's fueled in large part by excessive consumption of a fat-rich "Western diet."

30 Sep 2011

New technique helps identify how RNA molecules control gene expression

A new technique developed by researchers at the Stanford University School of Medicine allows researchers to identify the exact DNA sequences and locations bound by regulatory RNAs. This information is necessary to understand how the recently identified RNA molecules control the expression of neighboring and distant genes.

30 Sep 2011

Circadian files IND with FDA for VGX-100 for the treatment of cancer patients with solid tumors

Circadian Technologies Limited (ASX: CIR, OTCQX:CKDXY) is extremely proud to announce that its 100% owned subsidiary, Vegenics Pty Ltd, has submitted an investigational new drug (IND) application to the U.S. Food and Drug Administration (FDA) to initiate clinical studies of VGX-100. The first trial (Phase I) will involve the treatment of a variety of different cancer types in patients with late stage cancer.

29 Sep 2011

Researchers identify 'programmed cell death' pathway in parasitic worms

Researchers from the Walter and Eliza Hall Institute have for the first time identified a 'programmed cell death' pathway in parasitic worms that could one day lead to new treatments for one of the world's most serious and prevalent diseases.

29 Sep 2011

Molecule News and Research

First successful quantification of membrane lipids in a living cell

MicroRNA-101 can block autophagy in cancer cells

Researchers identify cellular pathway to potentially block disease-inducing inflammation

Researchers show how nuclear receptors battle each other during fruit fly metamorphosis

NCKU research team discovers potential target to treat osteoporosis

Scientists discover rare genetic alteration responsible for hypoglycaemia

Scientists discover new metabolic pathway which makes gliomas more aggressive

Scientists discover how cells detect tissue damage and modify their repair properties

Virus DNA uncoated with aid of host cell

Lipomannan on TB bacterium's outer cell surface can block TNF production

Researchers identify specific molecule that alters how breast cancer cells move

Researchers identify new enzyme function that may protect against anemia

La Jolla Institute scientist identifies previously unknown T cell interaction

ViroPharma licenses worldwide rights from Intellect Neurosciences to OX1 for treatment of FA

Study demonstrates how the intestine maintains 'immune tolerance' under healthy conditions

New targeting approach to develop an active site-directed, drug-like PTP1B inhibitor

Fat-rich 'western diet' fuels cardiovascular disease, type 2 diabetes and obesity

New technique helps identify how RNA molecules control gene expression

Circadian files IND with FDA for VGX-100 for the treatment of cancer patients with solid tumors

Researchers identify 'programmed cell death' pathway in parasitic worms

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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