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Mayo Clinic researchers advocate for comprehensive TPMT genotyping across ancestries

Mayo Clinic researchers found that a gene variant, the TPMT∗8 allele, is associated with reduced metabolism of the thiopurine class of drugs. TPMT∗8 is relatively common in individuals of African or African American descent. A novel study in The Journal of Molecular Diagnostics, published by Elsevier, details the researchers' goal to provide pharmacogenomic testing that can be used clinically to predict drug response that is beneficial to all patients, regardless of their ancestral background.

11 Dec 2024

How healthy plant-based diets enhance strength and function in aging adults

A study links healthy plant-based diets to improved physical performance and strength in aging adults, emphasizing diet quality over quantity.

10 Dec 2024

£1M funding boost for new project to trial Parkinson’s treatments on digital twin brain

£1m research project to advance ‘deep brain stimulation’ set to revolutionize Parkinson’s treatment and management

10 Dec 2024

Empathy-focused phone calls improve blood sugar control for low-income adults with diabetes

Empathy-focused phone calls made by trained, nonmedical community members led to significant improvements in blood sugar control for low-income adults with diabetes, according to a new study from Dell Medical School at The University of Texas at Austin in collaboration with Lone Star Circle of Care.

10 Dec 2024

Alcohol and substance use contribute to rising e-scooter and e-bike injuries

The numbers of e-scooter and e-bike injuries have tripled in the US since 2019, fuelled by alcohol and substance use, finds a nationwide analysis of emergency department visits, published online in the journal Injury Prevention.

10 Dec 2024

Eating breakfast later lowers blood sugar spikes in type 2 diabetes patients

Skipping early breakfasts may reduce blood sugar spikes in people with type 2 diabetes, with later breakfast timings showing significant benefits.

10 Dec 2024

X-chromosome study reveals hidden genetic links to Alzheimer’s disease

A groundbreaking study explores the overlooked X-chromosome’s role in Alzheimer’s disease, revealing seven genetic loci linked to neurodegenerative decline and cognitive reserve.

9 Dec 2024

Developing climate-resilient crops is essential for global food security

Increasing heat, droughts, floods, and salinization caused by climate change are lowering the amount of edible food produced by our staple crops.

9 Dec 2024

Writing by hand enhances brain function critical for learning

Handwriting activates key brain regions for memory and learning, suggesting educational systems should integrate traditional and digital methods effectively.

9 Dec 2024

Why does tinnitus worsen after naps?

Sstudy identifies how somatosensory factors, including snoring and sleep apnea, contribute to tinnitus loudness increases during naps. Researchers found temporary but measurable effects, suggesting that tensor veli palatini muscle dysfunction may play a role in these changes.

8 Dec 2024

Filgotinib offers new promise for managing Crohn’s disease

Filgotinib, a JAK1 preferential inhibitor, shows promise as an effective and well-tolerated maintenance therapy for Crohn's disease, achieving clinical and endoscopic remission in phase 3 trials. The findings highlight its potential as a novel therapeutic option for difficult-to-treat patients.

8 Dec 2024

Antidepressant use linked to persistent genital sensitivity loss

The use of antidepressants is associated with sexual side effects including reduced genital sensitivity that persists after stopping the medication, a new Simon Fraser University study finds.

6 Dec 2024

More plant protein, less animal protein tied to lower heart disease risk, not stroke

Research shows that increasing the plant-to-animal protein ratio in diets may lower cardiovascular disease and coronary artery disease risks, excluding stroke.

6 Dec 2024

Five servings of dark chocolate a week may protect against type 2 diabetes

Eating five servings of dark chocolate a week is associated with a reduction in the risk of type 2 diabetes, according to a long-term US study published by The BMJ today.

6 Dec 2024

Brief bursts of activity linked to heart health benefits for women

Research shows 3.4 minutes of daily VILPA is associated with a 45% reduction in major adverse cardiovascular events, highlighting sex differences in benefits.

5 Dec 2024

Creatine and resistance workouts combat sarcopenia

Combining creatine supplementation with resistance training boosts muscle strength, lean mass, and cognitive health in older adults, offering a safe and effective strategy against sarcopenia.

4 Dec 2024

Mexican American women show highest rates of medication nonadherence after stroke

Women who have had a stroke may be less likely than men to take medications to prevent a second stroke, with Mexican American women reporting the highest rates of nonadherence, according to new research published today in the Journal of the American Heart Association, an open access, peer-reviewed journal of the American Heart Association.

4 Dec 2024

Spinal manipulation linked to lower butalbital use in tension-type headaches

A team of researchers led by University Hospitals Connor Whole Health have identified an association between spinal manipulative therapy (SMT) and a reduced likelihood of butalbital prescription and medication overuse headache (MOH) for patients experiencing tension-type headaches (TTH). Their retrospective study, published in Health Science Reports, includes more than 6,200 patients from a national US database spanning 2013 to 2024.

3 Dec 2024

Minority genetic variation in tuberculosis offers new insights for improving outbreak tracking

Findings show that within-host MTBC variation improves transmission inference, suggesting new strategies for understanding and controlling tuberculosis spread.

2 Dec 2024

Study challenges long-standing understanding of axon structure

Biology textbooks may need a revision, say Johns Hopkins Medicine scientists, who present new evidence that an armlike structure of mammalian brain cells may be a different shape than scientists have assumed for more than a century.

2 Dec 2024