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SARS-CoV-2 ORF8 and the expression of cytokine in human macrophages

A new study has determined the production of the SARS-CoV-2 SP-dependent ORF8.

18 Aug 2021

Severe COVID-19 characterized by phosphorylation of STAT1

A new study reports an enhanced expression of STAT1 in mild and severely infected COVID-19 patients as compared to controls

18 Aug 2021

Research suggests toll-like receptor 4 appears to play role in severe COVID

A group of researchers re-evaluated their previously proposed hypothesis, which stated that the TLR4 activated by the spike glycoprotein S1 domain increases ACE2 expression and, thereby, aids in COVID-19 infection.

16 Aug 2021

Certain intestinal bacteria induce cross-reactive IgA responses to the SARS-CoV-2 spike RBD

A new study finds that human gut bacteria can induce antibodies of the immunoglobulin A (IgA) subtype that cross-react with the SARS-CoV-2 spike RBD.

15 Aug 2021

Enzyme acts as a sensor to find the hiding spots of viruses

While some types of RNA viruses cloak themselves to hide inside a cell and create copies of themselves, a "detective enzyme" might be attuned to their whereabouts. A slight variation in their genomic code gives some people's cells the capacity to produce this sensor.

14 Aug 2021

Targeting a skin protein may reduce the severity of psoriasis, study reveals

Results from a Michigan Medicine study reveal that targeting a protein found in the skin may reduce the severity of psoriasis.

12 Aug 2021

Defective process in the development of RBCs may trigger lupus

The autoimmune disease lupus may be triggered by a defective process in the development of red blood cells (RBCs), according to a study led by researchers at Weill Cornell Medicine.

11 Aug 2021

Plant-based virus-like particle vaccine induces durable immune response against SARS-CoV-2 variants

Scientists from Germany and Belgium have recently described the immunogenicity of a plant-based virus-like particle vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The vaccine induces robust antibody and T cell responses for at least 6 months. Moreover, the vaccine demonstrates potent neutralizing efficacy against the B.1.1.7, B.1.351, and P1 variants of SARS-CoV-2.

11 Aug 2021

Study shows efficacy of gamma irradiation of SARS-CoV-2 vaccine candidate in mouse model

A new study reports a more rapid method of viral inactivation in an effort to increase the appeal of inactivated viral vaccines against the COVID-19 pandemic.

10 Aug 2021

Activation of NLRP3 inflammasome by the N protein of SARS-CoV-2 to induce hyperinflammation

A new study has revealed the mechanism by which the SARS-CoV-2 N protein activates NLRP3 inflammasomes to induce hyperinflammation.

5 Aug 2021

The role of natural killer cells in the fight against coronavirus infection

This study proposes a mathematical framework to analyze the effect of the viruses on type I interferon (IFN-I) signaling, which is part of the innate immune response. IFN-I brings about natural killer cell activation, which in turn causes the activation of macrophages.

4 Aug 2021

Inhibition of SARS-CoV-2 replication in vitro by Losartan

A new study explores the use of Losartan to provide protection against COVID-19 pathogenesis.

3 Aug 2021

What is the potential of microphysiological systems in COVID-19 research?

In a recently published review article in the journal Drug Discovery Today, scientists have described the utility of human-based microphysiological systems MPSs in understanding the pathophysiology of SARS-CoV-2 infection and developing effective therapeutic interventions. Moreover, they have described the establishment of a global working group to synchronize recent developments around MPSs and COVID-19 research.

3 Aug 2021

Study looks at potent phytocompounds from Himalayan herbs to treat COVID-19

Considering the antiviral activity of medicinal herbs, a new study published in the journal Current Pharmacology Reports focuses on the identification of potent phytochemicals from Himalayan herbs, namely, Rheum emodi, Thymus serpyllum, and Artemisia annua, for the treatment of COVID-19.

1 Aug 2021

In-silico prediction of effective drug combinations for the treatment of SARS-CoV-2 infection

A new study published on the bioRxiv preprint server has developed the first computational model, i.e., a signaling network model, that can predict effective repurposed drug combinations to treat different phases of COVID-19 disease. This study has focused on identifying drugs for the treatment of early- and late-stage severe disease.

30 Jul 2021

Study examines the role of programmed cell death ligands in skin immune responses

T cells are a crucial part of the human adaptive immune system. In response to a foreign invader in the body, various subsets of T cells are responsible for several functions that include killing infected cells and secreting signaling molecules called cytokines that tell other immune cells where to go and what to do.

29 Jul 2021

Immunity to SARS-CoV-2 in renal transplant and dialysis patients using Pfizer/BioNTech and Moderna vaccines

A study analyzes the immune responses of medical personnel, as well as immunocompromised DP and immunosuppressed KTR patients.

27 Jul 2021

Impaired immune response to SARS-CoV-2 mRNA vaccination in immunocompromised patients

A new study describes how immunocompromised vaccine recipients may not always respond as expected to the COVID-19 vaccine.

27 Jul 2021

Scientists identify an antiviral metabolite as a potential serum biomarker for SARS-CoV-2 infection

Scientists from the UK have recently identified an antiviral metabolite 3'-Deoxy-3',4'-didehydro-cytidine as a potential serum biomarker to diagnose active severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The study is currently available on the medRxiv* preprint server while awaiting peer review.

27 Jul 2021

A novel interferon-γ release assay for detection of SARS-CoV-2 specific T-cell response

A new study evaluates a commercially available IFN‐γ release assay (IGRA) to determine T-cell responses targeted against SARS-CoV-2.

26 Jul 2021

Interferon News and Research

SARS-CoV-2 ORF8 and the expression of cytokine in human macrophages

Severe COVID-19 characterized by phosphorylation of STAT1

Research suggests toll-like receptor 4 appears to play role in severe COVID

Certain intestinal bacteria induce cross-reactive IgA responses to the SARS-CoV-2 spike RBD

Enzyme acts as a sensor to find the hiding spots of viruses

Targeting a skin protein may reduce the severity of psoriasis, study reveals

Defective process in the development of RBCs may trigger lupus

Plant-based virus-like particle vaccine induces durable immune response against SARS-CoV-2 variants

Study shows efficacy of gamma irradiation of SARS-CoV-2 vaccine candidate in mouse model

Activation of NLRP3 inflammasome by the N protein of SARS-CoV-2 to induce hyperinflammation

The role of natural killer cells in the fight against coronavirus infection

Inhibition of SARS-CoV-2 replication in vitro by Losartan

What is the potential of microphysiological systems in COVID-19 research?

Study looks at potent phytocompounds from Himalayan herbs to treat COVID-19

In-silico prediction of effective drug combinations for the treatment of SARS-CoV-2 infection

Study examines the role of programmed cell death ligands in skin immune responses

Immunity to SARS-CoV-2 in renal transplant and dialysis patients using Pfizer/BioNTech and Moderna vaccines

Impaired immune response to SARS-CoV-2 mRNA vaccination in immunocompromised patients

Scientists identify an antiviral metabolite as a potential serum biomarker for SARS-CoV-2 infection

A novel interferon-γ release assay for detection of SARS-CoV-2 specific T-cell response

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