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Review: The multifaceted roles of bilirubin in liver health and disease

Bilirubin, the byproduct of hemoprotein breakdown, particularly hemoglobin, is a critical marker in diagnosing, prognosing, and managing liver diseases.

6 Nov 2024

Rice bioengineers uncover why IL-12 immunotherapy loses effectiveness

A team of Rice University bioengineers has developed a mathematical model that clarifies why interleukin-12 (IL-12) ⎯ a potent immune-boosting protein that holds promise for cancer treatment ⎯ loses effectiveness over time when used as an immunotherapeutic.

6 Nov 2024

Multitarget stool DNA test shows promise for early colorectal cancer detection

A recent prospective cross-sectional study in Thailand demonstrates that multitarget stool DNA testing is highly sensitive and specific for detecting colorectal cancer (CRC) among Thai individuals.

6 Nov 2024

New insights into the role of innate immunity in tumor initiation

Along with defending against pathogens, the body's innate immune system helps to protect the stability of our genomes in unexpected ways - ways that have important implications for the development of cancer, researchers at Memorial Sloan Kettering Cancer Center (MSK) are discovering.

5 Nov 2024

No evidence Trump’s drug program for terminal patients saved ‘thousands’ of lives

Former President Donald Trump has boasted in recent months about "Right To Try," a law he signed in 2018. It's aimed at boosting terminally ill patients' access to potentially lifesaving medications not yet approved by the Food and Drug Administration.

5 Nov 2024

Werner syndrome gene plays key role in maintaining cellular organization and DNA stability

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 20 on October 17, 2024, entitled, "Werner syndrome RECQ helicase participates in and directs maintenance of the protein complexes of constitutive heterochromatin in proliferating human cells."

5 Nov 2024

New technology for visualizing AMPA receptors offers insights into psychiatric disorders

Even though psychiatric disorders such as schizophrenia, bipolar disorder, and autism spectrum disorder (ASD) are quite common, their diagnosis and treatment are challenging.

5 Nov 2024

Barrow researchers display Andrea Vesalius' anatomical manikins for the first time

For the first time, researchers at Phoenix's Barrow Neurological Institute have collected and displayed together the "manikins" published nearly 500 years ago by the 16th Century anatomist Andrea Vesalius – works that laid the foundation for modern surgical and neurosurgical training.

4 Nov 2024

Knee replacement surgery outcomes improve with native alignment approach

When performing knee replacement surgery, also called total knee arthroplasty, doctors traditionally try to align the hip, knee, and ankle in a straight line, forming a neutral alignment, rather than replicating the patient's original alignment.

4 Nov 2024

Scientists develop synthetic genes that can build intracellular structures

Researchers from the UCLA Samueli School of Engineering and the University of Rome Tor Vergata in Italy have developed synthetic genes that function like the genes in living cells.

4 Nov 2024

Unexpected immunotherapy success in rare pancreatic cancer

A new case report was published in Oncotarget's Volume 15 on October 11, 2024, entitled "A case of adenosquamous pancreatic cancer with a KRAS G12C mutation with an exceptional response to immunotherapy"

4 Nov 2024

Menthol cigarette restrictions could lead to healthier choices

Nationwide, fewer people smoke than did a decade ago, but the proportion who smoke menthol-flavored cigarettes is on the rise.

4 Nov 2024

Advanced deep learning technique enhances choroidal vessel visualization

Researchers from Peking University have developed a novel noninvasive choroidal angiography method that enables layer-wise visualization and evaluation of choroidal vessels using deep learning.

4 Nov 2024

New imaging tool analyzes extracellular vesicles to track cancer progression

A University of Rochester research team is reporting a new way to detect cancer cells with a "liquid biopsy" that's designed to be simpler, faster, and more informational than current methods.

4 Nov 2024

Rare neural crest stem cells identified as key drivers of cellular reprogramming

A team led by researchers at the University of Toronto has discovered that a group of cells located in the skin and other areas of the body, called neural crest stem cells, are the source of reprogrammed neurons found by other researchers.

3 Nov 2024

Study ties PM2.5 from agriculture to memory issues in children

A new USC study involving 8,500 children from across the country reveals that a form of air pollution, largely the product of agricultural emissions, is linked to poor learning and memory performance in 9- and 10-year-olds.

3 Nov 2024

Researchers achieve accurate EV analysis to detect brain disease

Brain disorders like Parkinson's (PD) or Alzheimer's Disease (AD) start to develop in patients much earlier than when their first clinical symptoms appear. Treating patients at these early stages could slow or even stop their disease, but there is currently no way to diagnose brain disorders at those pre-symptomatic stages.

3 Nov 2024

Combination therapy shows promising results in treating stage 3 melanoma

Pre-surgery treatment with the novel drug vidutolimod and the PD-1 checkpoint inhibitor nivolumab led to tumor control in 55% of patients with stage 3 cutaneous melanoma, according to the results of a single-arm phase 2 clinical trial led by the University of Pittsburgh, UPMC Hillman Cancer Center and the National Cancer Institute (NCI).

1 Nov 2024

Enhanced screening protocols for Candida auris improve hospital infection control

Mount Sinai researchers have enhanced hospital screening protocols for Candida auris, an often-drug-resistant fungal pathogen the Centers for Disease Control and Prevention considers an urgent global health threat.

1 Nov 2024

Elevated cytokines found in the blood of long COVID sufferers explain heart problems

University of Queensland-led research has found inflammatory markers in the blood of long COVID patients which could explain why many experience ongoing cardiovascular issues.

1 Nov 2024

OCT News and Research

Review: The multifaceted roles of bilirubin in liver health and disease

Rice bioengineers uncover why IL-12 immunotherapy loses effectiveness

Multitarget stool DNA test shows promise for early colorectal cancer detection

New insights into the role of innate immunity in tumor initiation

No evidence Trump’s drug program for terminal patients saved ‘thousands’ of lives

Werner syndrome gene plays key role in maintaining cellular organization and DNA stability

New technology for visualizing AMPA receptors offers insights into psychiatric disorders

Barrow researchers display Andrea Vesalius' anatomical manikins for the first time

Knee replacement surgery outcomes improve with native alignment approach

Scientists develop synthetic genes that can build intracellular structures

Unexpected immunotherapy success in rare pancreatic cancer

Menthol cigarette restrictions could lead to healthier choices

Advanced deep learning technique enhances choroidal vessel visualization

New imaging tool analyzes extracellular vesicles to track cancer progression

Rare neural crest stem cells identified as key drivers of cellular reprogramming

Study ties PM2.5 from agriculture to memory issues in children

Researchers achieve accurate EV analysis to detect brain disease

Combination therapy shows promising results in treating stage 3 melanoma

Enhanced screening protocols for Candida auris improve hospital infection control

Elevated cytokines found in the blood of long COVID sufferers explain heart problems

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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